The mechanism of autophagy inducing drug resistance of hepatocellular carcinoma

Runbing ZHANG; Tingting SHI; Yang WU; Jiucong ZHANG; Xiaofeng ZHENG

doi:10.12449/JCH241128

Volume 40 Issue 11

Nov. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(11): 2315-2319

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The mechanism of autophagy inducing drug resistance of hepatocellular carcinoma

DOI: 10.12449/JCH241128

Runbing ZHANG^{1, 2},
Tingting SHI^{1, 2},
Yang WU^{1, 2},
Jiucong ZHANG^{1
,
,
,},
Xiaofeng ZHENG^{3
,
,
,}

1.
The First Clinical College of Gansu University of Chinese Medicine，Lanzhou 730000，China
2.
Department of Gastroenterology，The 940 Hospital of Joint Logistic Support Force of PLA，Lanzhou 730050，China
3.
Department of Gastroenterology，The Second Hospital of Lanzhou University，Lanzhou 730030，China

Research funding:

The Central University Outstanding Youth Team training Project (1001451201);

Youth Project of Gansu Provincial Natural Science Foundation (22JR5RA1012)

More Information

Corresponding author: ZHANG Jiucong， zhangjiucong@163.com （ORCID： 0000-0003-4006-3033）; ZHENG Xiaofeng， zhengxf19892013@126.com （ORCID： 0009-0002-9660-1224）
Received Date: 2024-02-04
Accepted Date: 2024-03-29
Published Date: 2024-11-25

Abstract

Abstract

Treatment resistance of hepatocellular carcinoma （HCC） is an important factor restricting its treatment outcome. Autophagy is a process involving multiple steps and targets and is closely associated with the proliferation and apoptosis of tumor cells. At the same time， there is significant crosstalk between autophagy and tumor treatment resistance. Therefore， autophagy may be one of the key factors hindering tumor cell death after medical intervention. Transforming growth factor-β （TGF-β）， epithelial-mesenchymal transition （EMT）， and long non-coding RNA （lncRNA） are important factors leading to drug resistance of HCC. This article discusses the possible mechanism of TGF-β， EMT， and lncRNA mediating complex molecular networks and inducing drug resistance of HCC， in order to provide new ideas for improving the sensitivity of HCC treatment.
- Carcinoma， Hepatocellular,
- Autophagy,
- Drug Resistance， Neoplasm

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References(42)

References

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The mechanism of autophagy inducing drug resistance of hepatocellular carcinoma

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The mechanism of autophagy inducing drug resistance of hepatocellular carcinoma

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