The role of endoplasmic reticulum stress in non-alcoholic fatty liver disease and related targeted therapies

Xiuyan LI; Na LEI; Hongfei SONG; Ling ZENG; Dong WANG; Jie MU

doi:10.12449/JCH241126

Volume 40 Issue 11

Nov. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(11): 2300-2305

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The role of endoplasmic reticulum stress in non-alcoholic fatty liver disease and related targeted therapies

DOI: 10.12449/JCH241126

Xiuyan LI¹,
Na LEI²,
Hongfei SONG¹,
Ling ZENG¹,
Dong WANG¹,
Jie MU^{1
,
,
,}

1.
School of Basic Medical Sciences，Chengdu University of Traditional Chinese Medicine，Chengdu 611137，China
2.
Chongqing Traditional Chinese Medicine Hospital，Chongqing 400021，China

Research funding:

Youth Fund of National Natural Science Foundation of China (82104655);

General Project of National Science Foundation of Sichuan Province (2024NSFSC0692)

More Information

Corresponding author: MU Jie， 1041415560@qq.com （ORCID： 0000-0003-3466-238X）
Received Date: 2024-01-26
Accepted Date: 2024-04-08
Published Date: 2024-11-25

Abstract

Abstract

Non-alcoholic fatty liver disease （NAFLD） is a series of diseases characterized by hepatic steatosis and is also a metabolism-associated disease and an important factor for liver fibrosis， liver cirrhosis， and hepatocellular carcinoma. Endoplasmic reticulum is a core organelle for the regulation of lipid metabolism， and unfolded protein response is an important process of endoplasmic reticulum stress （ERS）. Based on the important stress role of endoplasmic reticulum in metabolism-associated diseases， this article explores the influencing mechanism between ERS and NAFLD and reviews the research advances in lipid metabolism， inflammatory response， hepatocyte death， fibrosis， and ERS-targeted therapies in the pathological development of NAFLD.
- Non-alcoholic Fatty Liver Disease,
- Endoplasmic Reticulum Stress,
- Unfolded Protein Response,
- Molecular Targeted Therapy

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References

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The role of endoplasmic reticulum stress in non-alcoholic fatty liver disease and related targeted therapies

DOI: 10.12449/JCH241126

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The role of endoplasmic reticulum stress in non-alcoholic fatty liver disease and related targeted therapies

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