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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 40 Issue 9
Sep.  2024
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Article Contents

Role of macrophages in the development and progression of primary biliary cholangitis

DOI: 10.12449/JCH240932
Research funding:

National Natural Science Foundation of China (82060385);

Innovation Fund for Graduate Students of Kunming Medical University in 2024 (2024S091)

More Information
  • Corresponding author: TAI Wenlin, taiwenlin2685@163.com (ORCID: 0000-0002-8278-929X)
  • Received Date: 2024-01-09
  • Accepted Date: 2024-03-07
  • Published Date: 2024-09-25
  • Primary biliary cholangitis (PBC) is a persistent inflammatory autoimmune liver disease characterized by inflammatory injury and cholestasis in the small intrahepatic bile ducts. At present, the exact pathogenesis of PBC remains unknown, but a consensus has been reached on the fact that PBC is the result of the synergistic effect of various factors. In the cascade of immune and inflammatory reactions associated with PBC, macrophages appear as essential immune cells and actively participate in the damage to bile duct epithelial cells. This article introduces the origin and heterogeneity of macrophages in PBC and reviews the potential role of macrophages in the pathogenesis of PBC.

     

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