Role of liver regeneration in the repair of liver injury induced by N-acetyl-p-aminophenol

Yinkang MO; Zihao FAN; Feng REN

doi:10.12449/JCH240929

Volume 40 Issue 9

Sep. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(9): 1902-1907

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Role of liver regeneration in the repair of liver injury induced by N-acetyl-p-aminophenol

DOI: 10.12449/JCH240929

Beijing Institute of Hepatology，Beijing YouAn Hospital，Capital Medical University，Beijing 100069，China

Research funding:

National Natural Science Foundation of China (81770611);

National Natural Science Foundation of China (82002243);

Key Projects of the Beijing Municipal Education Commission’s Science and Technology Plan (KZ202010025035);

Special Key Research Project of Capital Health Development Scientific Research (SF2020-1-1151);

Capital Clinical Characteristic Diagnosis and Treatment Technology Research and Transformation Application (Z191100006619096);

Capital Clinical Characteristic Diagnosis and Treatment Technology Research and Transformation Application (Z191100006619097);

Beijing Hospitals Authority Youth Programme (QML20201702);

Talent Cultivation Plan of “Climbing the peak” of Beijing Municipal Hospital Administration (DFL20221503);

High-level Public Health Technical Personnel Construction Project (Subject leaders-02-13);

Proposed Funding Project for the 2023 Beijing Natural Science Foundation Changping Innovation Joint Fund (L234046)

More Information

Corresponding author: REN Feng， renfeng7512@ccmu.edu.cn （ORCID： 0000-0001-7736-8637）
Received Date: 2023-12-28
Accepted Date: 2024-04-22
Published Date: 2024-09-25

Abstract

Abstract

Liver regeneration plays a crucial role in the recovery after liver injury induced by N-acetyl-p-aminophenol （APAP）. After APAP overdose， the degree of regeneration increases with the extent of liver injury， leading to the resolution of liver injury and spontaneous recovery in most cases. However， severe APAP overdose can impair liver regeneration and result in uncontrolled liver injury， even failure to recover or death in severe cases. Following APAP-induced liver injury， interactions between cells in the liver are essential for regenerative response. Liver regeneration is jointly regulated by multiple proliferative signaling pathways， involving various kinases， nuclear receptors， transcription factors， and coactivators. Severe APAP overdose can inhibit the activation of proliferative signaling pathways， thereby causing cell cycle arrest and impairing liver regeneration. Although liver regeneration plays a critical role in the repair of APAP-induced liver injury， the underlying mechanisms remain unclear. This article reviews the research advances in the role of liver regeneration in APAP-induced liver injury， in order to provide a reference for further basic research in this area.
- Chemical and Drug Induced Liver Injury,
- Acetaminophen,
- Signal Transduction,
- Repair

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References

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Role of liver regeneration in the repair of liver injury induced by N-acetyl-p-aminophenol

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Role of liver regeneration in the repair of liver injury induced by N-acetyl-p-aminophenol

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