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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 40 Issue 9
Sep.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(9): 1873-1879

The mechanism of compound traditional Chinese medicine prescriptions in reversal of liver fibrosis and early liver cirrhosis

DOI: 10.12449/JCH240924
  • 1.

    Institute of Liver Disease，Beijing University of Chinese Medicine，Beijing 100007，China

  • 2.

    Department of Gastroenterology and Hepatology，Dongfang Hospital，Beijing University of Chinese Medicine，Beijing 100078，China

  • 3a.

    Department of Gastroenterology，Dongzhimen Hospital，Beijing University of Chinese Medicine，Beijing 100007，China

  • 3b.

    Department of Infectious Diseases，Dongzhimen Hospital，Beijing University of Chinese Medicine，Beijing 100007，China

Research funding:

Youth Science Foundation of National Natural Science Foundation of China (82104810)

More Information
  • Corresponding author: ZHANG Peng， zp891223@126.com （ORCID： 0000-0003-0215-3572）; YE Yongan， yonganye2022@163.com （ORCID： 0000-0001-9765-4665）
  • Received Date: 2024-01-22
  • Accepted Date: 2024-02-21
  • Published Date: 2024-09-25
    Abstract
  • Liver fibrosis and cirrhosis are the common outcomes of various chronic liver diseases after progression， and studies have shown that liver fibrosis and early liver cirrhosis can be reversed. Compound traditional Chinese medicine prescriptions have a marked therapeutic effect in reversing liver fibrosis and early liver cirrhosis， and their mechanism of action remains unclear. By reviewing related articles in China and globally， this article summarizes the six main phenotypic mechanisms involved in the efficacy of compound traditional Chinese medicine prescriptions， i.e.， inhibiting liver inflammation and regulating liver immune response， regulating hepatic stellate cell activation and extracellular matrix （ECM） generation， promoting ECM degradation， reversing hepatic sinusoidal capillarization， regulating hepatocyte regeneration， and regulating gut microbiota， and in addition， this article also analyzes the advances and shortcomings in current studies on each phenotype. Future studies on compound traditional Chinese medicine prescriptions should focus on experimental exploration and rescue experiments to verify the above phenotypes and further explore the upstream and downstream signaling pathways with a marked effect. This article aims to help clarify the direction and ideas of studies on the therapeutic mechanism of compound traditional Chinese medicine prescriptions， in order to provide a basis for clarifying the scientific essence of compound traditional Chinese medicine prescriptions.

     

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