Strategies and practice of conversion therapy for hepatocellular carcinoma

Due to the insidious onset and poor prognosis of primary liver cancer， most patients are found to have unresectable primary liver cancer at initial diagnosis. In recent years， with the advent of targeted therapy， immunotherapy， and local therapy， some patients with advanced liver cancer have achieved successful conversion and undergone radical surgical resection， but at the same time， such treatment has brought many issues， such as the identification of potential population for conversion， the selection of conversion regimen， the necessity and timing of surgical resection after conversion， and the necessity and duration of adjuvant therapy after conversion surgery. This article discusses the above problems in conversion therapy for liver cancer based on the author’s own experience.