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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 40 Issue 4
Apr.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(4): 850-856

Mechanism and prevention of liver failure complicated by acute pancreatitis

DOI: 10.12449/JCH240434

  • Department of Hepatology，The First Affiliated Hospital of Hunan University of Chinese Medicine，Changsha 410000，China

Research funding:

Natural Science Foundation of Hunan Province (2022JJ30458);

Science and Technology Plan Project of Changsha (kq2202451)

More Information
  • Corresponding author: PENG Jianping， jppeng@126.com （ORCID： 0009-0001-2437-9153）
  • Received Date: 2023-08-17
  • Accepted Date: 2023-09-13
  • Published Date: 2024-04-25
    Abstract
  • Liver failure often has rapid progression， multiple complications， and dangerous conditions. Acute pancreatitis is a common comorbidity during the progression of liver failure， and since acute pancreatitis has extremely similar clinical symptoms and signs to liver failure complicated by spontaneous peritonitis， it is often neglected in clinical practice. This article elaborates on the mechanisms of liver failure complicated by acute pancreatitis from the five aspects of inflammatory response， duodenal papillary dysfunction， gut microbiota dysbiosis， oxidative stress， and microcirculatory disturbance and proposes corresponding preventive measures based on these mechanisms.

     

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