Association between deacetylase Sirtuins and radiation-induced liver disease

Yekai ZONG; Jiangkai LIU

doi:10.12449/JCH240233

Volume 40 Issue 2

Feb. 2024

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(2): 419-425

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Association between deacetylase Sirtuins and radiation-induced liver disease

DOI: 10.12449/JCH240233

Yekai ZONG¹,
Jiangkai LIU^{2
,
,
,}

1.
The First Clinical Medical College of Henan University of Chinese Medicine，Zhengzhou 450008，China
2.
Spleen，Stomach and Hepatobiliary Department，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450008，China

Research funding:

National Natural Science Foundation of China (U1504825);

Henan TCM Top-Notch Talent Program (CZ20262-19);

Construction Project of Traditional Chinese Medicine in Henan Province (STG-ZYX04-202133)

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Corresponding author: LIU Jiangkai， 13592553982@126.com （ORCID： 0000-0002-1529-5089）
Received Date: 2023-05-17
Accepted Date: 2023-06-25
Published Date: 2024-02-19

Abstract

Abstract

Radiation-induced liver disease （RILD）， also known as radiation hepatitis， is subacute liver injury induced by radiation. As the focus of senescence-related studies， the deacetylase family Sirtuins （SIRTs） have the molecular functions including DNA repair and chromatin regulation， which makes SIRTs a hub for regulating genome and epigenome stability. Radiation-induced hepatic DNA damage and reaction is the primary physiological and pathological process of RILD， which is similar to the function of SIRTs. This article briefly introduces the structure and function of the SIRTs protein family， elaborates on the basic concepts and progress of the physical physiology of radiation therapy， discusses the internal relationship between SIRTs and RILD from the perspective of radiobiology， and points out the possibility of SIRTs as a target for the prevention and treatment of RILD.
- Radiation-Induced Liver Disease,
- Sirtuins,
- Radiation， Ionizing

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References

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Association between deacetylase Sirtuins and radiation-induced liver disease

DOI: 10.12449/JCH240233

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Association between deacetylase Sirtuins and radiation-induced liver disease

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