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Volume 40 Issue 2
Feb.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(2): 402-407

Pathogenesis of liver injury caused by antiviral drugs for coronavirus disease 2019

DOI: 10.12449/JCH240230

  • Department of Gastroenterology，Affiliated Hospital of Zunyi Medical University，Zunyi，Guizhou 563000，China

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  • Corresponding author: WANG Hong， wanghong89zy@163.com （ORCID： 0000-0001-5411-3041）
  • Received Date: 2023-06-16
  • Accepted Date: 2023-07-14
  • Published Date: 2024-02-19
    Abstract
  • Drug-induced liver injury is caused by the drug itself and/or its metabolites during drug use or occurs due to hypersensitivity or reduced tolerance to the drug in a particular body type. In the last three years of the diagnosis and treatment of coronavirus disease 2019 （COVID-19）， antiviral drugs have played a very important role， but there are many reports on liver injury caused by anti-COVID-19 drugs in China and globally， with unknown pathogenesis of liver injury caused by such drugs. This article reviews the research advances in the types of antiviral drugs for COVID-19 and their mechanism in inducing liver injury， in order to promote the rational use of antiviral drugs.

     

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