Research advances in second-line therapies for hepatocellular carcinoma after resistance to targeted therapy combined with immunotherapy

Tianqi ZHANG; Yuzhe CAO; Mengxuan ZUO; Yangkui GU

doi:10.12449/JCH240227

Volume 40 Issue 2

Feb. 2024

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Abstract

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Article Navigation > Journal of Clinical Hepatology > 2024 > 40(2): 386-390

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Research advances in second-line therapies for hepatocellular carcinoma after resistance to targeted therapy combined with immunotherapy

DOI: 10.12449/JCH240227

Tianqi ZHANG^{1, 2},
Yuzhe CAO^{1, 2},
Mengxuan ZUO^{1, 2},
Yangkui GU^{1, 2
,
,
,}

1.
Department of Minimally Invasive Interventional Therapy，Sun Yat-sen University Cancer Center，Guangzhou 510060，China
2.
State Key Laboratory of Oncology in South China，Guangzhou 510060，China

Research funding:

Guangzhou Science and Technology Program Civic Technology Research Plan (2024A04J4245);

Natural Science Foundation of Guangdong Province (2020A1515011539)

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Corresponding author: GU Yangkui， guyk@sysucc.org.cn （ORCID： 0000-0002-6689-7338）
Received Date: 2023-03-20
Accepted Date: 2023-05-18
Published Date: 2024-02-19

Abstract

Abstract

In recent years， clinical studies on targeted therapy and immunotherapy for advanced hepatocellular carcinoma used alone or in combination have provided abundant evidence on efficacy and safety for the selection of first-line therapies. However， no consensus has been reached on the selection of second-line therapies in various clinical guidelines for hepatocellular carcinoma， which is caused by the fact that existing evidence is limited to the options after failure of sorafenib and that there is still a lack of high-level evidence for new first-line therapies such as second-line therapies after resistance to targeted therapy and immunotherapy for hepatocellular carcinoma. This article reviews the results of current clinical trials and summarizes the studies on second-line therapies for hepatocellular carcinoma after resistance to first-line targeted therapy and immunotherapy for hepatocellular carcinoma based on the different mechanisms of action of drugs， as well as the research advances in recent years. For hepatocellular carcinoma patients with resistance to first-line targeted therapy and immunotherapy， targeted combination therapy and dual-immune therapy are expected to improve treatment outcome and survival， and more prospective clinical studies are needed in the future to provide effective and safe treatment regimens for hepatocellular carcinoma patients with resistance to targeted therapy and immunotherapy.
- Carcinoma， Hepatocellular,
- Drug Therapy,
- Drug Resistance， Neoplasm

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References

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