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Volume 40 Issue 1
Jan.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(1): 181-186

Role of exosomes in intrahepatic cholangiocarcinoma

DOI: 10.12449/JCH240130
  • 1.

    Department of Oncology，The Affiliated Hospital of Southwest Medical University，Luzhou，Sichuan 646000，China

  • 2.

    Department of Oncology，Langfang People’s Hospital，Langfang，Hebei 065000，China

Research funding:

National Natural Science Foundation of China (81903000);

Natural Science Foundation of Sichuan Province (2023NSFSC1846)

More Information
  • Corresponding author: LUO Yuhao， luoyuhao1992@swmu.edu.cn （ORCID： 0000-0002-7489-5770）
  • Received Date: 2023-04-18
  • Accepted Date: 2023-06-15
  • Published Date: 2024-01-23
    Abstract
  • Intrahepatic cholangiocarcinoma （ICC） is a special type of liver cancer with atypical clinical symptoms in the early stage， and most patients are already in the advanced stage at the time of initial diagnosis. Due to a lack of effective molecular markers and treatment options， ICC patients tend to have an extremely low five-year survival rate. Exosomes are vesicles secreted by cells that contain proteins， RNA， and lipids， and they are important carriers of intercellular communication. Recent studies have shown that exosomes play a crucial role in the development and progression of ICC， and this article reviews the role and mechanism of exosomes in the diagnosis and treatment of ICC and looks into the future treatment prospect and potential clinical application of exosomes.

     

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