Research advances in traditional Chinese medicine regulation of programmed cell death in intervening against hepatic fibrosis

Liangjiang HUANG; Dewen MAO; Rongzhen ZHANG; Guochu HUANG; Han WANG; Weibin QIN; Chun YAO

doi:10.12449/JCH240127

Volume 40 Issue 1

Jan. 2024

Turn off MathJax

Article Contents

Article Navigation > Journal of Clinical Hepatology > 2024 > 40(1): 161-168

PDF( 731 KB)

Research advances in traditional Chinese medicine regulation of programmed cell death in intervening against hepatic fibrosis

DOI: 10.12449/JCH240127

1.
Graduate School of Guangxi University of Chinese Medicine，Nanning 530200，China
2.
Department of Hepatology，The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530023，China

Research funding:

Guangxi Key Research and Development Plan Projects (GK AB22035076);

Innovation Project of Guangxi Graduate Education (YCSW2022343);

Guangxi Degree and Graduate Education Reform Project “Exploration and Practice of the Training Mode of TCM Master Elite Talents by Inheriting ‘Guangxi Famous Doctors and Famous Teachers’” (JGY2022182)

More Information

Corresponding author: YAO Chun， yaochun111@163.com （ORCID： 0000-0003-2903-8814）
Received Date: 2023-04-24
Accepted Date: 2023-06-27
Published Date: 2024-01-23

Abstract

Abstract

Hepatic fibrosis （HF） is a pathological process of abnormal repair of liver tissue structure caused by chronic liver injury， and its pathogenesis has not been fully clarified. Related studies have shown that programmed cell death may be associated with the onset of HF， and traditional Chinese medicine （TCM） has a significant effect in regulating programmed cell death to intervene against HF. This article reviews the main mechanism of the influence of programmed cell death on HF and discusses the possible mechanism of TCM regulation of programmed cell death in improving HF， which provides new ideas for TCM prevention and treatment of HF.
- Hepatic Fibrosis,
- Traditional Chinese Drugs,
- Programmed Cell Death

FullText(HTML)

References(64)

References

[1]	GBD 2021 Diabetes Collaborators. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021[J]. Lancet, 2023, 402( 10397): 203- 234. DOI: 10.1016/S0140-6736(23)01301-6.
[2]	GILGENKRANTZ H, MALLAT A, MOREAU R, et al. Targeting cell-intrinsic metabolism for antifibrotic therapy[J]. J Hepatol, 2021, 74( 6): 1442- 1454. DOI: 10.1016/j.jhep.2021.02.012.
[3]	HAO M, HAN X, YAO ZH, et al. The pathogenesis of organ fibrosis: Focus on necroptosis[J]. Br J Pharmacol, 2022. DOI: 10.1111/bph.15952.[ Online ahead of print].
[4]	KIM KM, CHO SS, KI SH. Emerging roles of ferroptosis in liver pathophysiology[J]. Arch Pharm Res, 2020, 43( 10): 985- 996. DOI: 10.1007/s12272-020-01273-8.
[5]	KALE J, OSTERLUND EJ, ANDREWS DW. BCL-2 family proteins: Changing partners in the dance towards death[J]. Cell Death Differ, 2018, 25( 1): 65- 80. DOI: 10.1038/cdd.2017.186.
[6]	ASHKENAZI A, SALVESEN G. Regulated cell death: Signaling and mechanisms[J]. Annu Rev Cell Dev Biol, 2014, 30: 337- 356. DOI: 10.1146/annurev-cellbio-100913-013226.
[7]	CANBAY A, FELDSTEIN AE, HIGUCHI H, et al. Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression[J]. Hepatology, 2003, 38( 5): 1188- 1198. DOI: 10.1053/jhep.2003.50472.
[8]	GUO R, JIA XH, DING ZB, et al. Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation[J]. Theranostics, 2022, 12( 11): 5220- 5236. DOI: 10.7150/thno.71400.
[9]	GROOTJANS S, VANDEN BERGHE T, VANDENABEELE P. Initiation and execution mechanisms of necroptosis: An overview[J]. Cell Death Differ, 2017, 24( 7): 1184- 1195. DOI: 10.1038/cdd.2017.65.
[10]	CHOI ME, PRICE DR, RYTER SW, et al. Necroptosis: A crucial pathogenic mediator of human disease[J]. JCI Insight, 2019, 4( 15): e128834. DOI: 10.1172/jci.insight.128834.
[11]	GALLUZZI L, KEPP O, CHAN FKM, et al. Necroptosis: Mechanisms and relevance to disease[J]. Annu Rev Pathol, 2017, 12: 103- 130. DOI: 10.1146/annurev-pathol-052016-100247.
[12]	LALAOUI N, LINDQVIST LM, SANDOW JJ, et al. The molecular relationships between apoptosis, autophagy and necroptosis[J]. Semin Cell Dev Biol, 2015, 39: 63- 69. DOI: 10.1016/j.semcdb.2015.02.003.
[13]	MOHAMMED S, NICKLAS EH, THADATHIL N, et al. Role of necroptosis in chronic hepatic inflammation and fibrosis in a mouse model of increased oxidative stress[J]. Free Radic Biol Med, 2021, 164: 315- 328. DOI: 10.1016/j.freeradbiomed.2020.12.449.
[14]	ROYCHOWDHURY S, MCMULLEN MR, PISANO SG, et al. Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury[J]. Hepatology, 2013, 57( 5): 1773- 1783. DOI: 10.1002/hep.26200.
[15]	GAUTHERON J, VUCUR M, REISINGER F, et al. A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis[J]. EMBO Mol Med, 2014, 6( 8): 1062- 1074. DOI: 10.15252/emmm.201403856.
[16]	de VASCONCELOS NM, van OPDENBOSCH N, van GORP H, et al. Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture[J]. Cell Death Differ, 2019, 26( 1): 146- 161. DOI: 10.1038/s41418-018-0106-7.
[17]	ALEGRE F, PELEGRIN P, FELDSTEIN AE. Inflammasomes in liver fibrosis[J]. Semin Liver Dis, 2017, 37( 2): 119- 127. DOI: 10.1055/s-0037-1601350.
[18]	ORNING P, WENG D, STARHEIM K, et al. Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death[J]. Science, 2018, 362( 6418): 1064- 1069. DOI: 10.1126/science.aau2818.
[19]	XU YJ, ZHENG L, HU YW, et al. Pyroptosis and its relationship to atherosclerosis[J]. Clin Chim Acta, 2018, 476: 28- 37. DOI: 10.1016/j.cca.2017.11.005.
[20]	WREE A, MEHAL WZ, FELDSTEIN AE. Targeting cell death and sterile inflammation loop for the treatment of nonalcoholic steatohepatitis[J]. Semin Liver Dis, 2016, 36( 1): 27- 36. DOI: 10.1055/s-0035-1571272.
[21]	ZHANG YP, WANG Y, DI LQ, et al. Mechanism of interleukin-1β-induced proliferation in rat hepatic stellate cells from different levels of signal transduction[J]. APMIS, 2014, 122( 5): 392- 398. DOI: 10.1111/apm.12155.
[22]	PALACIOS-MACAPAGAL D, CONNOR J, MUSTELIN T, et al. Cutting edge: Eosinophils undergo caspase-1-mediated pyroptosis in response to necrotic liver cells[J]. J Immunol, 2017, 199( 3): 847- 853. DOI: 10.4049/jimmunol.1601162.
[23]	GATICA D, LAHIRI V, KLIONSKY DJ. Cargo recognition and degradation by selective autophagy[J]. Nat Cell Biol, 2018, 20( 3): 233- 242. DOI: 10.1038/s41556-018-0037-z.
[24]	SEKI E, BRENNER DA. Recent advancement of molecular mechanisms of liver fibrosis[J]. J Hepatobiliary Pancreat Sci, 2015, 22( 7): 512- 518. DOI: 10.1002/jhbp.245.
[25]	ALLAIRE M, RAUTOU PE, CODOGNO P, et al. Autophagy in liver diseases: Time for translation?[J]. J Hepatol, 2019, 70( 5): 985- 998. DOI: 10.1016/j.jhep.2019.01.026.
[26]	TANG DL, KROEMER G. Ferroptosis[J]. Curr Biol, 2020, 30( 21): R1292- R1297. DOI: 10.1016/j.cub.2020.09.068.
[27]	YU Y, YAN Y, NIU FL, et al. Ferroptosis: A cell death connecting oxidative stress, inflammation and cardiovascular diseases[J]. Cell Death Discov, 2021, 7( 1): 193. DOI: 10.1038/s41420-021-00579-w.
[28]	LEI G, ZHUANG L, GAN BY. Targeting ferroptosis as a vulnerability in cancer[J]. Nat Rev Cancer, 2022, 22( 7): 381- 396. DOI: 10.1038/s41568-022-00459-0.
[29]	ZHANG ZL, GUO M, SHEN M, et al. The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells[J]. Redox Biol, 2020, 36: 101619. DOI: 10.1016/j.redox.2020.101619.
[30]	ZHU YM, ZHANG CH, HUANG MZ, et al. TRIM26 induces ferroptosis to inhibit hepatic stellate cell activation and mitigate liver fibrosis through mediating SLC7A11 ubiquitination[J]. Front Cell Dev Biol, 2021, 9: 644901. DOI: 10.3389/fcell.2021.644901.
[31]	GAO MH, MONIAN P, PAN QH, et al. Ferroptosis is an autophagic cell death process[J]. Cell Res, 2016, 26( 9): 1021- 1032. DOI: 10.1038/cr.2016.95.
[32]	CHEN TT. Based on the prevention and treatment mechanism of TGF-β1/Smad 2 signaling pathway[D]. Chengdu: Chengdu University of Traditional Chinese Medicine, 2022. 陈甜甜. 基于TGF-β1/Smad2信号通路探讨桂枝茯苓丸防治肝纤维化的作用机制[D]. 成都: 成都中医药大学, 2022.
[33]	LIU ZL, XU BG, DING YP, et al. Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways[J]. Bioengineered, 2022, 13( 4): 9357- 9368. DOI: 10.1080/21655979.2022.2054224.
[34]	WANG SL, TANG C, ZHAO H, et al. Network pharmacological analysis and experimental validation of the mechanisms of action of Si-Ni-San against liver fibrosis[J]. Front Pharmacol, 2021, 12: 656115. DOI: 10.3389/fphar.2021.656115.
[35]	ZHANG DQ, ZHANG LJ, CHEN GF, et al. Hepatoprotective effect of Xiayuxue Decoction ethyl acetate fraction against carbon tetrachloride-induced liver fibrosis in mice via inducing apoptosis and suppressing activation of hepatic stellate cells[J]. Pharm Biol, 2020, 58( 1): 1229- 1243. DOI: 10.1080/13880209.2020.1855212.
[36]	MA Z, XUE XY, BAI JZ, et al. Si-Wu-Tang ameliorates bile duct ligation-induced liver fibrosis via modulating immune environment[J]. Biomed Pharmacother, 2022, 155: 113834. DOI: 10.1016/j.biopha.2022.113834.
[37]	JIA Y. Studies on the role of curcumol-induced HSC necroptosis in anti-hepatic fibrosis and the underlying mechanism[D]. Nanjing: Nanjing University of Chinese Medicine, 2019. 贾岩. 莪术醇调控HSC程序性坏死在抗肝纤维化中的作用及其分子机制研究[D]. 南京: 南京中医药大学, 2019.
[38]	SUN SM, HUAN S, LI ZH, et al. Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway[J]. Peer J, 2022, 10: e13376. DOI: 10.7717/peerj.13376.
[39]	SUN, LI Z, HUAN S, et al. Modification of lysine deacetylation regulates curcumol-induced necroptosis through autophagy in hepatic stellate cells[J]. Phytother Res, 2022, 36( 6): 2660- 2676. DOI: 10.1002/ptr.7483
[40]	JIA Y, WANG FX, GUO Q, et al. Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells[J]. Redox Biol, 2018, 19: 375- 387. DOI: 10.1016/j.redox.2018.09.007.
[41]	GONG LH, ZHOU HL, ZHANG SL, et al. CD44-targeting drug delivery system of exosomes loading forsythiaside A combats liver fibrosis via regulating NLRP3-mediated pyroptosis[J]. Adv Healthc Mater, 2023, 12( 11): e2202228. DOI: 10.1002/adhm.202202228.
[42]	CHEN S, FAN C, ZHANG JF, et al. The mechanism of Shugan Jianpi Formula regulating TLR4/MyD88/NLRP3 signaling axis to inhibit pyroptosis in mice with liver fibrosis[J]. Chin J Clin Pharmacol Ther, 2022, 27( 10): 1081- 1089. DOI: 10.12092/j.issn.1009-2501.2022.10.001. 陈森, 凡畅, 张家富, 等. 疏肝健脾方调控TLR4/My D88/N LRP3信号轴抑制肝纤维化小鼠细胞焦亡的机制研究[J]. 中国临床药理学与治疗学, 2022, 27( 10): 1081- 1089. DOI: 10.12092/j.issn.1009-2501.2022.10.001.
[43]	ZHANG N, LI Y. Study on protective effect of bupleurin D on human hepatocyte injury and mechanism of anti-liver fibrosis[J]. Chin Arch Tradit Chin Med, 2021, 39( 12): 21- 27, 275. DOI: 10.13193/j.issn.1673-7717.2021.12.005. 张娜, 李勇. 柴胡皂苷d对人肝细胞损伤的保护作用研究及抗肝纤维化机制探讨[J]. 中华中医药学刊, 2021, 39( 12): 21- 27, 275. DOI: 10.13193/j.issn.1673-7717.2021.12.005.
[44]	LI Y, ZHENG YD, LONG FL, et al. Study on the mechanism of Baihuaxianglian Jiedu Granule regulating AMPK/mTOR pathway and inhibiting autophagy and activation of hepatic stellate cells[J]. J Chin Med Mater, 2023, 46( 2): 469- 473. DOI: 10.13863/j.issn1001-4454.2023.02.034. 李媛, 郑亚东, 龙富立, 等. 白花香莲解毒颗粒调控AMPK/mTOR通路抑制肝星状细胞自噬和活化的作用机制研究[J]. 中药材, 2023, 46( 2): 469- 473. DOI: 10.13863/j.issn1001-4454.2023.02.034.
[45]	TAN YH, LI C, DENG FM, et al. Berberine relieves liver fibrosis in mice by inhibiting autophagy of hepatic stellate cells[J]. J Chengdu Med Coll, 2023, 18( 1): 33- 38. DOI: 10.3969/j.issn.1674-2257.2023.01.007. 谭悦浩, 李灿, 邓峰美, 等. 小檗碱通过抑制肝星状细胞自噬改善小鼠肝纤维化[J]. 成都医学院学报, 2023, 18( 1): 33- 38. DOI: 10.3969/j.issn.1674-2257.2023.01.007.
[46]	ZHANG YQ, HUA LP, LIN CF, et al. Pien-Tze-Huang alleviates CCl₄-induced liver fibrosis through the inhibition of HSC autophagy and the TGF-β1/Smad2 pathway[J]. Front Pharmacol, 2022, 13: 937484. DOI: 10.3389/fphar.2022.937484.
[47]	SHI YH, YAN T, LU X, et al. Phloridzin reveals new treatment strategies for liver fibrosis[J]. Pharmaceuticals, 2022, 15( 7): 896. DOI: 10.3390/ph15070896.
[48]	LIU GF, WEI C, YUAN SY, et al. Wogonoside attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis through SOCS₁/P53/SLC7A11 pathway[J]. Phytother Res, 2022, 36( 11): 4230- 4243. DOI: 10.1002/ptr.7558.
[49]	KONG ZY, LIU R, CHENG YR. Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway[J]. Biomed Pharmacother, 2019, 109: 2043- 2053. DOI: 10.1016/j.biopha.2018.11.030.
[50]	HUANG S, WANG YH, XIE SW, et al. Isoliquiritigenin alleviates liver fibrosis through caveolin-1-mediated hepatic stellate cells ferroptosis in zebrafish and mice[J]. Phytomedicine, 2022, 101: 154117. DOI: 10.1016/j.phymed.2022.154117.
[51]	XU JB, GAO GC, YUAN MJ, et al. Lignans from Schisandra chinensis ameliorate alcohol and CCl₄-induced long-term liver injury and reduce hepatocellular degeneration via blocking ETBR[J]. J Ethnopharmacol, 2020, 258: 112813. DOI: 10.1016/j.jep.2020.112813.
[52]	LIU YM, CONG S, CHENG Z, et al. Platycodin D alleviates liver fibrosis and activation of hepatic stellate cells by regulating JNK/c-JUN signal pathway[J]. Eur J Pharmacol, 2020, 876: 172946. DOI: 10.1016/j.ejphar.2020.172946.
[53]	HUANG X, WANG LH, MENG MY, et al. Extract of Averrhoacarambola L.(Oxalidaceae) roots ameliorates carbon tetrachloride-induced hepatic fibrosis in rats[J]. Biomed Pharmacother, 2020, 121: 109516. DOI: 10.1016/j.biopha.2019.109516.
[54]	TIAN HJ, LIU L, LI ZX, et al. Chinese medicine CGA formula ameliorates liver fibrosis induced by carbon tetrachloride involving inhibition of hepatic apoptosis in rats[J]. J Ethnopharmacol, 2019, 232: 227- 235. DOI: 10.1016/j.jep.2018.11.027.
[55]	DU XS, LI HD, YANG XJ, et al. Wogonin attenuates liver fibrosis via regulating hepatic stellate cell activation and apoptosis[J]. Int Immunopharmacol, 2019, 75: 105671. DOI: 10.1016/j.intimp.2019.05.056.
[56]	LI ZB, JIANG L, NI JD, et al. Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells[J]. Acta Pharmacol Sin, 2023, 44( 6): 1191- 1205. DOI: 10.1038/s41401-022-01044-9.
[57]	XIONG Y, HU JY, XUAN C, et al. Transcriptome analysis reveals the molecular mechanism of Yiqi Rougan Decoction in reducing CCl₄-induced liver fibrosis in rats[J]. Chin Med, 2021, 16( 1): 142. DOI: 10.1186/s13020-021-00552-w.
[58]	XIE ZY, XU YX, ZHENG MY, et al. Anti-pyroptosis effect of Albiziae Cortex-Tribuli Fructus combination on hepatic stellate cell line LX2: Based on network pharmacology[J]. China J Chin Mater Med, 2023, 48( 2): 481- 491. DOI: 10.19540/j.cnki.cjcmm.20221011.401. 谢泽宇, 许一笑, 郑梦圆, 等. 基于网络药理学探究合欢皮-白蒺藜药对抑制肝星状细胞系LX2的抗焦亡作用[J]. 中国中药杂志, 2023, 48( 2): 481- 491. DOI: 10.19540/j.cnki.cjcmm.20221011.401.
[59]	QUE RY, CAO MX, DAI YC, et al. Decursin ameliorates carbon-tetrachloride-induced liver fibrosis by facilitating ferroptosis of hepatic stellate cells[J]. Biochem Cell Biol, 2022, 100( 5): 378- 386. DOI: 10.1139/bcb-2022-0027.
[60]	BERUMEN J, BAGLIERI J, KISSELEVA T, et al. Liver fibrosis: Pathophysiology and clinical implications[J]. WIREs Mech Dis, 2021, 13( 1): e1499. DOI: 10.1002/wsbm.1499.
[61]	FAN WY, HAO JY, CHEN HX, et al. Research progress on signal pathways in hepatic fibrosis and targeted regulation mechanisms of active ingredients from traditional Chinese medicine[J]. J Clin Hepatol, 2022, 38( 11): 2599- 2605. DOI: 10.3969/j.issn.1001-5256.2022.11.033. 范文艳, 郝君玉, 陈虹秀, 等. 肝纤维化相关信号通路及中药活性成分靶向调节作用机制[J]. 临床肝胆病杂志, 2022, 38( 11): 2599- 2605. DOI: 10.3969/j.issn.1001-5256.2022.11.033.
[62]	JIANG RZ, CHEN XC, HU P, et al. Mechanism of“Zedoary Turmeric-Rhizoma Sparganii” against liver fibrosis based on network pharmacology[J/CD]. Chin J Liver Dis(Electronic Version), 2022, 14( 3): 39- 44. DOI: 10.3969/j.issn.1674-7380.2022.03.008. 蒋蕊竹, 陈鑫昌, 胡萍, 等. 基于网络药理学探讨“莪术-三棱”抗肝纤维化作用机制[J/CD]. 中国肝脏病杂志(电子版), 2022, 14( 3): 39- 44. DOI: 10.3969/j.issn.1674-7380.2022.03.008.
[63]	HAMZA AA, LASHIN FM, GAMEL M, et al. Hawthorn herbal preparation from Crataegus oxyacantha attenuates in vivo carbon tetrachloride-induced hepatic fibrosis via modulating oxidative stress and inflammation[J]. Antioxidants, 2020, 9( 12): 1173. DOI: 10.3390/antiox9121173.
[64]	PENG YH, LI Y, ZHANG K, et al. Research progress of autophagy and liver fibrosis and regulation of traditional Chinese medicine[J]. China Med Herald, 2023, 20( 4): 52- 55, 63. DOI: 10.20047/j.issn1673-7210.2023.04.11. 彭云鹤, 李媛, 张衎, 等. 自噬与肝纤维化及中医药调控的研究进展[J]. 中国医药导报, 2023, 20( 4): 52- 55, 63. DOI: 10.20047/j.issn1673-7210.2023.04.11.

Relative Articles

Supplements(0)

Cited By

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Tables(1)

Get Citation

PDF

XML

Article Metrics

Article views (419) PDF downloads(33)

Research advances in traditional Chinese medicine regulation of programmed cell death in intervening against hepatic fibrosis

DOI: 10.12449/JCH240127

Abstract

References

Proportional views

Catalog

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Proportional views

Related

About Journal

Submission Guideline

Journal Online

Hepatobiliary College

Guidelines

Export File

Citation

Format

Content