2023 No. 4

2023 No.4

Theme Issue: Emphasizing Hepatitis D Virus Infection

Executive Chief Editor: ZHUANG Hui

School of Basic Medical Sciences, Peking University

Cover Content

Previous Issue | Next Issue

Select articles

Display Method:

Editorial

The research on hepatitis D should be taken seriously

Hui ZHUANG

2023, 39(4): 737-741. DOI: 10.3969/j.issn.1001-5256.2023.04.001

Abstract(755)

HTML (116)

PDF (1857KB)(145)

Abstract:
Hepatitis D virus (HDV) infection is an important health problem around the world. The epidemiology of HDV infection has been changed significantly over the past 10 years due to widespread hepatitis B vaccination and human migration. HDV infection can manifest as co-infection or superinfection. Pati...

Discussions by Experts

Research history of hepatitis D in China

Huimin LIU, Qing MAO

2023, 39(4): 742-750. DOI: 10.3969/j.issn.1001-5256.2023.04.002

Abstract(636)

HTML (106)

PDF (2300KB)(140)

Abstract:
Since the discovery of hepatitis D virus (HDV) in the 1970s, Chinese scholars have started to conduct extensive studies on HDV and hepatitis D (HD). By searching for related articles published on the platforms of Chinese scientific and technological journals and the journals in PubMed database by Ch...

Detection methods for hepatitis D antibodies: A comparative analysis

Zhenfeng ZHANG

2023, 39(4): 751-757. DOI: 10.3969/j.issn.1001-5256.2023.04.003

Abstract(589)

HTML (409)

PDF (1903KB)(115)

Abstract:
Hepatitis D is a severe form of viral hepatitis caused by co-infection with hepatitis D virus (HDV) and hepatitis B virus (HBV) or superinfection of HDV in HBV carriers. There is still a huge gap in the diagnosis of hepatitis D due to insufficient emphasis on this disease for a long time. With the a...

Current research status of hepatitis D virus RNA detection

Yao GAO, Feng REN, Zhongping DUAN

2023, 39(4): 758-765. DOI: 10.3969/j.issn.1001-5256.2023.04.004

Abstract(662)

HTML (134)

PDF (1807KB)(117)

Abstract:
Hepatitis D caused by hepatitis D virus (HDV) infection is the most serious type of viral hepatitis. The prevalence rate of HDV has been seriously underestimated due to the lack of accurate HDV RNA detection methods. HDV RNA is the gold standard for the diagnosis of HDV infection and is of great sig...

Epidemiological situation of hepatitis D in Xinjiang, China

Rongjiong ZHENG, Xiaobo LU

2023, 39(4): 766-770. DOI: 10.3969/j.issn.1001-5256.2023.04.005

Abstract(566)

HTML (185)

PDF (1775KB)(94)

Abstract:
Hepatitis D is a global public health issue, and the infection rate and genotype of HDV infection vary greatly across different regions. The overlapping infection of hepatitis D virus (HDV) in patients with chronic hepatitis B virus (HBV) infection can accelerate disease progression, but hepatitis D...

Epidemiological screening and detection indicators for hepatitis D and suitable populations

Xiumei CHI, Junqi NIU

2023, 39(4): 771-775. DOI: 10.3969/j.issn.1001-5256.2023.04.006

Abstract(653)

HTML (115)

PDF (1899KB)(106)

Abstract:
Hepatitis D virus (HDV) infection requires the participation of hepatitis B virus (HBV), which accelerates disease progression after infection and induces a high risk of progression to end-stage liver diseases such as liver cirrhosis and liver cancer. With the gradual increase in the understanding o...

Research advances in antiviral drugs for the treatment of hepatitis D

Yan WANG, Fujie ZHANG

2023, 39(4): 776-784. DOI: 10.3969/j.issn.1001-5256.2023.04.007

Abstract(685)

HTML (110)

PDF (2362KB)(113)

Abstract:
Hepatitis D virus (HDV) is a satellite virus of hepatitis B virus (HBV) and needs the help of HBV envelope protein to complete its own assembly and replication and then establish a new infection cycle. Chronic HDV infection is considered the most severe form of viral hepatitis, which can accelerate ...

Guideline

Expert consensus on the process of in-hospital screening and management of viral hepatitis E in China (2023)

Chinese Consortium for the Study of Hepatitis E(CCSHE), Chinese Physician Association for Infectious Disease, National Clinical Research Center for Infectious Diseases

2023, 39(4): 785-794. DOI: 10.3969/j.issn.1001-5256.2023.04.008

Abstract(1055)

HTML (163)

PDF (2826KB)(401)

Abstract:
Hepatitis E caused by hepatitis E virus (HEV) infection is an acute /chronic infectious disease with significant morbidity and mortality, which has become an important global health issue. Our understanding of HEV has changed completely over the past decade. Every year 20 million people are infected...

Original Article_Viral Hepatitis

An investigation of hepatitis D virus infection among patients with chronic hepatitis B virus infection in some regions of China

Yumei LIU, Xiaoping GUO, Huimin ZHANG, Hongxia BAI, Chunmei WANG, Shan REN, Yongfang JIANG, Sheng YANG, Feng PENG, Xiaozhong WANG, Lei YU, Boming LIAO, Ling NING, Yingli HE, Xia YANG, Liang HUANG, Xueen LIU, Hui ZHUANG

2023, 39(4): 795-803. DOI: 10.3969/j.issn.1001-5256.2023.04.009

Abstract(904)

HTML (187)

PDF (2049KB)(143)

Abstract:
Objective To investigate the prevalence of hepatitis D virus (HDV) infection among patients with chronic hepatitis B virus (HBV) infection in some regions of China. Methods Serum samples were collected from 3 131 patients with chronic HBV infection in 10 provinces, cities, and autonomous regions of ...

Original Article_Liver Fibrosis and Liver Cirrhosis

Effect of Compound Lingdan Capsule on liver function and fibrosis degree in mice with liver fibrosis

Zhixin TU, Yan WANG, Jianjie HUANG, Qinglong JIN

2023, 39(4): 804-809. DOI: 10.3969/j.issn.1001-5256.2023.04.010

Abstract(450)

HTML (80)

PDF (4219KB)(47)

Abstract:
Objective To investigate the effect of Compound Lingdan Capsule on serum biochemical parameters and liver fibrosis degree in a mouse model of liver fibrosis. Methods A total of 125 specific pathogen-free male C57BL/6 mice were randomly divided into normal control group with 5 mice, CCl₄ model group ...

Expression of Sema4D in peripheral blood T cells and serum of patients with hepatitis B cirrhosis and its clinical significance

Xue WEN, Yujing HE, Qianqian YUAN, Chuyi LI, Lixia LU, Xiaohui YU, Jiucong ZHANG

2023, 39(4): 810-817. DOI: 10.3969/j.issn.1001-5256.2023.04.011

Abstract(476)

HTML (192)

PDF (1814KB)(41)

Abstract:
Objective To investigate the expression of Sema4D in peripheral blood T cells and serum of patients with hepatitis B cirrhosis and its correlation with clinical indicators. Methods A total of 20 patients with chronic hepatitis B (CHB), 68 patients with hepatitis B cirrhosis, and 20 healthy controls ...

Value of different Baveno Ⅶ-based criteria in screening for high-risk esophageal and gastric varices in advanced chronic liver disease

Chunmei GUO, Hong LIU, Yadan WANG, Mingming MENG, Canghai WANG, Hui SU, Jing WU

2023, 39(4): 818-825. DOI: 10.3969/j.issn.1001-5256.2023.04.012

Abstract(386)

HTML (160)

PDF (2878KB)(49)

Abstract:
Objective To investigate the value of Baveno Ⅶ criteria versus Expanded Baveno Ⅶ criteria in screening for high-risk varices (HRV) in patients with compensated advanced chronic liver disease (cACLD). Methods A total of 146 patients with cACLD who were admitted to Beijing Shijitan Hospital, Capital M...

Value of spleen volume in predicting portal hypertensive gastropathy and its severity in patients with liver cirrhosis

Zhiqiang ZHANG, Wei CHEN, Bo LIU

2023, 39(4): 826-833. DOI: 10.3969/j.issn.1001-5256.2023.04.013

Abstract(421)

HTML (85)

PDF (2045KB)(51)

Abstract:
Objective To investigate the value of spleen volume (SV) in predicting portal hypertensive gastropathy (PHG) and severe PHG in patients with liver cirrhosis. Methods A retrospective analysis was performed for the clinical data of 168 patients with liver cirrhosis who were admitted to Xiangyang No.1 ...

Original Article_Liver Neoplasm

Safety and efficacy of camrelizumab added to second-line therapy after drug-eluting bead transarterial chemoembolization combined with apatinib for unresectable hepatocellular carcinoma

Yancang ZHANG, Manzhou WANG, Xinwei HAN, Xuhua DUAN, Jianzhuang REN, Hao LI, Wenhui WANG, Wenze XU

2023, 39(4): 834-842. DOI: 10.3969/j.issn.1001-5256.2023.04.014

Abstract(440)

HTML (252)

PDF (2022KB)(60)

Abstract:
Objective To investigate the safety and efficacy of camrelizumab added to second-line therapy after drug- eluting bead transarterial chemoembolization (DTACE) combined with apatinib for unresectable hepatocellular carcinoma (HCC). Methods A retrospective analysis was performed for 89 HCC patients wi...

Value of alpha-fetoprotein response in evaluating the efficacy of sorafenib combined with camrelizumab in treatment of advanced hepatocellular carcinoma

Xing WANG, Tao ZHANG

2023, 39(4): 843-849. DOI: 10.3969/j.issn.1001-5256.2023.04.015

Abstract(493)

HTML (105)

PDF (2203KB)(46)

Abstract:
Objective To investigate the value of alpha-fetoprotein (AFP) response in evaluating the clinical efficacy and safety of sorafenib combined with camrelizumab in the treatment of advanced hepatocellular carcinoma (HCC). Methods Clinical data were collected from 48 patients with advanced HCC who were ...

Original Article_Other Liver Disease

Clinical features of patients with malignant tumor-related pyogenic liver abscess

Gufen ZHANG, Na YAO, Mingyuan BI, Ye ZHANG, Wen KANG, Jianqi LIAN, Linxu WANG, Chunfu WANG

2023, 39(4): 850-855. DOI: 10.3969/j.issn.1001-5256.2023.04.016

Abstract(337)

HTML (91)

PDF (1784KB)(39)

Abstract:
Objective To investigate the clinical features of malignant tumor-related pyogenic liver abscess (PLA), and to provide a basis for early judgment of disease progression and timely and effective treatment. Methods A retrospective analysis was performed for the clinical data of 371 patients with PLA w...

Application of remote ischemic preconditioning combined with controlled low central venous pressure in hepatectomy

Yuansong GAO, Liu YANG, You WU, Na ZHANG, Chun TIAN

2023, 39(4): 856-863. DOI: 10.3969/j.issn.1001-5256.2023.04.017

Abstract(516)

HTML (78)

PDF (2448KB)(37)

Abstract:
Objective To investigate the application effect of remote ischemic preconditioning (RIPC) combined with controlled low central venous pressure (CLCVP) in hepatectomy. Methods A total of 80 patients who underwent elective partial hepatectomy in Yougchuan Hospital Affiliated to Chongqing Medical Unive...

Effect of Yudantong decoction on intestinal flora and intestinal barrier function in mice with cholestasis induced by α-naphthyl isothiocyanate

Xiaoming WU, Qiang HE, Linyi HOU, Yan HU, Xiaofang ZHEN, Jing HAO, Yan SHENG

2023, 39(4): 864-875. DOI: 10.3969/j.issn.1001-5256.2023.04.018

Abstract(550)

HTML (87)

PDF (9148KB)(56)

Abstract:
Objective To investigate the therapeutic effect of Yudantong decoction in mice with α-naphthyl isothiocyanate (ANIT)-induced cholestasis, as well as its targets and mechanism based on intestinal flora and intestinal barrier function. Methods A total of 24 C57BL/6 mice were randomly divided into cont...

Effect of exosomes derived from Echinococcus multilocularis on macrophage polarization: A preliminary study

Gengbo YE, Gongfu CHEN, Ziyan CUI, Junjie WU, Dengliang HUANG, Fengjiao YIN, Zhixin WANG, Wenhao YU, Fanyu KONG, Haining FAN, Li REN

2023, 39(4): 876-884. DOI: 10.3969/j.issn.1001-5256.2023.04.019

Abstract(428)

HTML (141)

PDF (5713KB)(51)

Abstract:
Objective To investigate the effect of exosomes derived from Echinococcus multilocularis on macrophage polarization after treatment for different durations and concentrations. Methods A total of 60 BALB/c mice were used for modeling, among which 4 mice were selected to observe the growth of abdomina...

Original Article_Biliary Disease

Application of indocyanine green fluorescence navigation in laparoscopic cholecystectomy after percutaneous transhepatic gallbladder drainage in elderly patients with acute cholecystitis

Changxu LI, Xuemin LI, Zhanqiang LIANG, Xibin DUAN, Pengsheng YANG

2023, 39(4): 885-891. DOI: 10.3969/j.issn.1001-5256.2023.04.020

Abstract(516)

HTML (72)

PDF (2950KB)(40)

Abstract:
Objective To investigate the clinical value of indocyanine green (ICG) fluorescence navigation in laparoscopic cholecystectomy (LC) after percutaneous transhepatic gallbladder drainage (PTGBD) in elderly patients with acute cholecystitis. Methods A retrospective analysis was performed for the periop...

Case Report

A case of hepatolenticular degeneration caused by ATP7B p.Ser1369Tyrfs^*24 mutation

Yuting LIU, Zhihui TANG, Qiong BIN

2023, 39(4): 892-895. DOI: 10.3969/j.issn.1001-5256.2023.04.021

Abstract(404)

HTML (72)

PDF (2373KB)(49)

Abstract:

Infantile familial chylomicronemia syndrome caused by LPL gene variants coexisting with renal hamartoma:A case report

Xintao CHEN, Weiyuan FANG, Xiaoyan GONG, Qiong LIN, Yi LU

2023, 39(4): 896-900. DOI: 10.3969/j.issn.1001-5256.2023.04.022

Abstract(474)

HTML (122)

PDF (2214KB)(31)

Abstract:

Primary clear cell carcinoma of the gallbladder: A case report

Yongshuo LIU, Junjie XIA, Xingyan SHEN, Yanlong WANG, Xiangjun SUN

2023, 39(4): 901-903. DOI: 10.3969/j.issn.1001-5256.2023.04.023

Abstract(348)

HTML (102)

PDF (1992KB)(47)

Abstract:

Cholecystoduodenal fistula with gallstone ileus accompanied by colon cancer: A case report

Wenbo LI, Liang LI, You JIANG, Jun ZHANG, Jun LU

2023, 39(4): 904-908. DOI: 10.3969/j.issn.1001-5256.2023.04.024

Abstract(432)

HTML (70)

PDF (2744KB)(43)

Abstract:

Review

Influence of white fat browning on nonalcoholic fatty liver disease

Chenlu ZHAO, Cheng ZHOU, Dongfang SHANG, Sutong LIU, Junhao SHI, Xiaojie WANG, Wenxia ZHAO

2023, 39(4): 909-914. DOI: 10.3969/j.issn.1001-5256.2023.04.025

Abstract(581)

HTML (126)

PDF (1786KB)(65)

Abstract:
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease in which a large amount of fat accumulates in hepatocytes due to lipid metabolism disorders. Conventional anti-inflammatory and transaminase-lowering treatment regimens often have an unsatisfactory therapeutic effect, and restoring ...

Research advances in pharmacotherapy for autoimmune hepatitis

Xiuying YANG, Xiaohong DANG, Yang JIANG

2023, 39(4): 915-921. DOI: 10.3969/j.issn.1001-5256.2023.04.026

Abstract(704)

HTML (153)

PDF (1801KB)(97)

Abstract:
Autoimmune hepatitis (AIH) is an immune-mediated chronic inflammatory liver disease. At present, standard treatment is effective in most AIH patients, and second- or third-line pharmacotherapy can be selected for patients who have suboptimal response to standard treatment or cannot tolerate the side...

A new perspective in the treatment of liver fibrosis: Targeting macrophage metabolism

Jun XU, Weilin IN, Xun LI

2023, 39(4): 922-928. DOI: 10.3969/j.issn.1001-5256.2023.04.027

Abstract(1235)

HTML (412)

PDF (2010KB)(326)

Abstract:
Liver fibrosis is a pathological process of fibrous scar formation caused by excessive accumulation of extracellular matrix due to various etiologies. At present, etiological treatment, such as effective antiviral therapy, is still the main treatment strategy for liver fibrosis. As the core particip...

Advances in the risk factors, pathogenesis, and treatment of liver cirrhosis with osteoporosis

Qiu JIN, Jing YANG, Honglin MA, Qingqing LIU, Pingju LI, Shaoshan HU

2023, 39(4): 929-935. DOI: 10.3969/j.issn.1001-5256.2023.04.028

Abstract(775)

HTML (189)

PDF (2227KB)(74)

Abstract:
Osteoporosis is a common extrahepatic complication of liver cirrhosis, and it not only increases the economic burden of patients, but also brings adverse effects on their quality of life and prognosis. Recent studies have shown that sarcopenia, adiponectin, leptin, irisin, and inflammatory factors a...

Application prospect of endoscopic ultrasound-guided portal pressure gradient measurement

Heng DU, Yongjun CHEN, Yong YAO

2023, 39(4): 936-940. DOI: 10.3969/j.issn.1001-5256.2023.04.029

Abstract(687)

HTML (112)

PDF (2038KB)(65)

Abstract:
Portal pressure measurement plays an important role in the diagnosis and evaluation of portal hypertension, and at present, there is still no unified method for the assessment of portal vein pressure. With the wide application of endoscopic ultrasound in digestive system diseases, endoscopic ultraso...

Application of immune checkpoint inhibitors in liver transplantation for patients with hepatocellular carcinoma

Youcheng XIE, Shun CHEN, Chuyi LI, Ying ZHENG, Dong JIA, Jiucong ZHANG, Xiaohui YU

2023, 39(4): 941-947. DOI: 10.3969/j.issn.1001-5256.2023.04.030

Abstract(607)

HTML (87)

PDF (2045KB)(50)

Abstract:
Liver transplantation, as one of the radical treatment strategies for hepatocellular carcinoma, has a good clinical effect in patients meeting the Milan criteria; however, the high recurrence rate and metastasis rate after surgery bring great challenges to the long-term survival of such patients. Th...

Role of new potential immune blocking molecules in the development and progression of hepatocellular carcinoma

Ying TAO, Zhangxiu LIAO

2023, 39(4): 948-955. DOI: 10.3969/j.issn.1001-5256.2023.04.031

Abstract(476)

HTML (178)

PDF (2476KB)(40)

Abstract:
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors around the world. The emergence of immune checkpoint inhibitors targeting programmed death-1/programmed death-ligand 1 and cytotoxic T lymphocyte-associated antigen-4 has brought great breakthroughs in the treatment of HCC. Ho...

The mechanism of p53 signaling pathway regulating ferroptosis in hepatocellular carcinoma

Zhen LI, Jiangkai LIU

2023, 39(4): 956-960. DOI: 10.3969/j.issn.1001-5256.2023.04.032

Abstract(886)

HTML (173)

PDF (1770KB)(60)

Abstract:
Hepatocellular carcinoma (HCC) is the most common type of liver cancer in China, and the development and progression of HCC is a complex pathological process. As a new way of cell death, ferroptosis has huge potential in the treatment of HCC. This article introduces the mechanism of action of the tu...

Role of non-coding RNA on immune cells in tumor microenvironment of hepatocellular carcinoma

Chaoran YANG, Sirou LI, Yuan LIU, Zhiyuan HOU, Yuan WANG, Jihong YANG

2023, 39(4): 961-967. DOI: 10.3969/j.issn.1001-5256.2023.04.033

Abstract(475)

HTML (100)

PDF (1794KB)(51)

Abstract:
Hepatocellular carcinoma (HCC) is a common malignant tumor of the liver characterized by a high incidence rate, rapid progression, and poor prognosis. In recent years, it has been found that non-coding RNA (ncRNA) participates in the regulation of tumor immunity in tumor microenvironment (TME) and i...

Research advances in pathogenesis, risk factors, monitoring, and retreatment of drug-induced liver injury

Rujia LIU, Xiaojuan XIN

2023, 39(4): 968-973. DOI: 10.3969/j.issn.1001-5256.2023.04.034

Abstract(691)

HTML (231)

PDF (1776KB)(160)

Abstract:
With the approval and launch of a large number of new drugs, the incidence rate of drug-induced liver injury (DILI) is increasing year by year, which may affect the treatment of primary diseases. As an adverse drug reaction, DILI cannot be completely eliminated, and the clinical goal is to minimize ...

Research advances in the treatment of Crigler-Najjar syndrome

Wenyan ZHANG, Guohong DENG

2023, 39(4): 974-979. DOI: 10.3969/j.issn.1001-5256.2023.04.035

Abstract(754)

HTML (200)

PDF (1785KB)(98)

Abstract:
Crigler-Najjar syndrome (CNS) is an autosomal recessive disorder in which the content of plasma unconjugated bilirubin is increased due to the reduction or complete deficiency of the activity of bilirubin uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1), classified as CNS type Ⅰ and Ⅱ. CNS ...

Association between endoplasmic reticulum stress and ferroptosis in liver diseases

Lu YE, Xiuqin LI, Jianqing WANG

2023, 39(4): 980-985. DOI: 10.3969/j.issn.1001-5256.2023.04.036

Abstract(981)

HTML (505)

PDF (2468KB)(110)

Abstract:
Research on the pathogenesis of liver diseases has attracted great attention. Endoplasmic reticulum stress (ERS) is a self-protective mechanism of cells, but sustained and severe ERS can induce apoptosis, autophagy, and ferroptosis, among which ferroptosis has been a research hotspot in recent years...

Advances in in vitro induction of hepatocyte-like cells and the application of small-molecule compounds in inducing hepatocyte-like cells

Wei TANG, Dongmei WANG

2023, 39(4): 986-992. DOI: 10.3969/j.issn.1001-5256.2023.04.037

Abstract(478)

HTML (346)

PDF (1796KB)(53)

Abstract:
The induction of hepatocyte-like cells (HLCs) in vitro is one of the effective ways to obtain a large number of useful hepatocyte, and these HLCs can be used in disease modeling, drug design, and toxicological evaluation. At present, the induction of HLCs in vitro is mainly achieved by introducing e...

Thanks

Current reviewers

2023, 39(4): 935-935. DOI: 10.3969/j.issn.1001-5256.2023.4.zhixie1

Abstract(148)

HTML (65)

PDF (758KB)(21)

Abstract: