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ISSN 2097-3497 (Online)
CN 22-1108/R
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2022 No.7
Theme Issue: Research Advances in Non-Cirrhotic Portal Hypertension
Executive Chief Editor: XU Xiaoyuan  
Peking University First Hospital
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Editorial
Current status of the clinical management of non-cirrhotic portal hypertension
Jinghang XU, Yanyan YU, Xiaoyuan XU
2022, 38(7): 1457-1459. DOI: 10.3969/j.issn.1001-5256.2022.07.001
Abstract(905) HTML (189) PDF (1903KB)(239)
Abstract:
Non-cirrhotic portal hypertension (NCPH) is not uncommon, and its clinical management strategies are different from those for cirrhotic portal hypertension. According to pathogenesis and etiology, NCPH can be classified into prehepatic, hepatic, and posthepatic NCPH, among which hepatic NCPH can be ...
Discussions by Experts
Research advances in the diagnosis and treatment of prehepatic noncirrhotic portal hypertension
Jiaqi YANG, Yulong SHANG, Ying HAN
2022, 38(7): 1460-1463. DOI: 10.3969/j.issn.1001-5256.2022.07.002
Abstract(766) HTML (167) PDF (1845KB)(175)
Abstract:
Prehepatic noncirrhotic portal hypertension is a group of diseases caused by noncirrhotic factors, and currently it is believed that the etiology of these diseases is mainly associated with JAK2 mutation and blood hypercoagulability. Main clinical manifestations include variceal bleeding and splenom...
Research advances in non-cirrhotic intrahepatic presinusoidal portal hypertension
Shuai XIA, Xiaoning WU, Bingqiong WANG, Zhiying HE, Hong YOU
2022, 38(7): 1464-1468. DOI: 10.3969/j.issn.1001-5256.2022.07.003
Abstract(767) HTML (186) PDF (1852KB)(163)
Abstract:
Non-cirrhotic intrahepatic presinusoidal portal hypertension is a subtype of non-cirrhotic portal hypertension, and patients with this disease have the symptoms of portal hypertension and do not have the pathological evidence for liver cirrhosis, with normal or slightly abnormal hepatic venous press...
Research advances in post-sinusoidal non-cirrhotic portal hypertension
Huiting CHEN, Yongjian ZHOU
2022, 38(7): 1469-1473. DOI: 10.3969/j.issn.1001-5256.2022.07.004
Abstract(737) HTML (136) PDF (1852KB)(120)
Abstract:
Portal hypertension (PH) is defined as the pathological increase in pressure in the portal venous system. The most common cause of PH is liver cirrhosis, but it is also observed in patients without liver cirrhosis, which is called non-cirrhotic portal hypertension. Non-cirrhotic portal hypertension ...
Current status of the clinical management of Budd-Chiari syndrome
Cui ZHOU, Bo SHEN, Ying QU, Lungen LU
2022, 38(7): 1474-1476. DOI: 10.3969/j.issn.1001-5256.2022.07.005
Abstract(733) HTML (190) PDF (1820KB)(149)
Abstract:
Budd-Chiari syndrome is an uncommon disease due to hepatic venous outflow obstruction, and hypercoagulability of the body is the main etiology of this disease. At present, radiological examination is commonly used to make a confirmed diagnosis, and anticoagulant therapy and angioplasty are the main ...
Academic Contention
HBeAg-negative chronic HBV-infected individuals with normal alanine aminotransferase and an age of ≤30 years should be taken seriously when expanding anti-HBV treatment for chronic hepatitis B
Yanna LIU, Mingwei LI, Leijie WANG, Hong ZHAO, Shuangsuo DANG, Xiangmei CHEN, Jingmin ZHAO, Fengmin LU
2022, 38(7): 1477-1481. DOI: 10.3969/j.issn.1001-5256.2022.07.006
Abstract(878) HTML (340) PDF (2010KB)(163)
Abstract:
Objective To validate and refine the recommendations in the recently published expert opinion on expanding anti-HBV treatment for chronic hepatitis B. Methods Adult individuals with chronic HBV infection and normal alanine aminotransferase (ALT) who underwent liver biopsy in The Fifth Medical Center...
Original Articles_Viral Hepatitis
Value of lactate level in predicting the short-term prognosis of patients with acute-on-chronic hepatitis B liver failure
Shuo YANG, Kun LIU, Lan YANG, Ling XU, Xiaobo LU, Xiaofeng SUN, MALIPATI Elkenjiang
2022, 38(7): 1482-1488. DOI: 10.3969/j.issn.1001-5256.2022.07.007
Abstract(710) HTML (242) PDF (2603KB)(94)
Abstract:
Objective To investigate the value of lactate in predicting the 90-day prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). Methods A retrospective analysis was performed for 117 patients with HBV-ACLF who were admitted to Center for Infectious Diseases-Hep...
Changes and clinical significance of natural killer-like B cells, natural killer cells, and B cells in peripheral blood of patients with hepatitis B virus infection
Xiaofei YANG, Huanjun SHEN, Gaobo HUANG, Jianqi LIAN, Ye ZHANG
2022, 38(7): 1489-1494. DOI: 10.3969/j.issn.1001-5256.2022.07.008
Abstract(768) HTML (145) PDF (2862KB)(69)
Abstract:
Objective To investigate the changes of natural killer-like B (NKB) cells, natural killer (NK) cells, and B cells and their correlation with clinical indices in patients with hepatitis B virus (HBV) infection. Methods A total of 15 patients with acute hepatitis B (AHB), 30 patients with chronic hepa...
Mechanism of astragaloside Ⅳ inhibits hepatitis B virus replication by regulating host ribosome translation process
Kai CHANG, Yanyan WANG, Wanlin NA, Chenxia LIU, Yusheng YE, Zhongyong JIANG, Yuan LIU
2022, 38(7): 1495-1502. DOI: 10.3969/j.issn.1001-5256.2022.07.009
Abstract(689) HTML (153) PDF (4201KB)(45)
Abstract:
Objective To investigate the host regulatory mechanism of astragaloside Ⅳ in inhibiting hepatitis B virus (HBV) replication. Methods Normal human hepatocytes L-02 were treated with different concentrations of astragaloside Ⅳ, and according to the concentration of astragaloside Ⅳ, the cells were divi...
Mechanism of Lingmao Formula in treatment of chronic hepatitis B based on network pharmacology and animal experiment
Lijie MA, Xiaojun ZHU, Jiacheng LIN, Fang WANG, Xuehua SUN, Yueqiu GAO
2022, 38(7): 1503-1508. DOI: 10.3969/j.issn.1001-5256.2022.07.010
Abstract(629) HTML (162) PDF (3685KB)(70)
Abstract:
Objective To investigate the association between Lingmao Formula and type Ⅰ interferon in the treatment of chronic hepatitis B. Methods TCMSP database was used to obtain the main active components of Lingmao Formula; Genecards database was used to obtain the targets of Lingmao Formula and chronic he...
Analysis of the results of hepatitis C antibody screening in 2020 in Yanbian area of China
Yang ZHOU, Chaoxu FU, Min ZHOU, Lei XU, Mingyang LI, Yingsheng SHEN, Hongxin PIAO, Enyue YANG
2022, 38(7): 1509-1512. DOI: 10.3969/j.issn.1001-5256.2022.07.011
Abstract(595) HTML (245) PDF (1850KB)(48)
Abstract:
Objective To investigate the influencing factors for hepatitis C antibody and the preventive effect of hepatitis C in Yanbian Prefecture of China in the recent 7 years. Methods A total of 1184 residents in Yanbian were randomly selected in 2020, peripheral blood samples were collected, and the collo...
Original Articles_Fatty Liver Diseases
Mechanism of action of Eupolyphaga steleophaga in improving nonalcoholic steatohepatitis by regulating syndecan 3
Guangyue YANG, Le TAO, Wei ZHANG, Xuling LIU, Wenting MA, Liu WU, Tiantian SUN, Hao JIANG, Cheng LIU
2022, 38(7): 1513-1520. DOI: 10.3969/j.issn.1001-5256.2022.07.012
Abstract(561) HTML (165) PDF (5504KB)(52)
Abstract:
Objective To investigate the effect of Eupolyphaga steleophaga on nonalcoholic steatohepatitis induced by choline-deficient L-amino acid-defined diet (CDAA) and its mechanism by regulating syndecan 3. Methods A total of 18 male C57BL/6 mice were randomly divided into choline-sufficient L-amino acid-...
Original Articles_Autoimmune Liver Diseases
Features and prognosis of Hashimoto's thyroiditis in patients with primary biliary cholangitis
Jingyi ZHANG, Yingmei. TANG
2022, 38(7): 1521-1528. DOI: 10.3969/j.issn.1001-5256.2022.07.013
Abstract(722) HTML (154) PDF (1892KB)(72)
Abstract:
Objective To investigate the clinical features, related factors, and prognosis of Hashimoto's thyroiditis (HT) in patients with primary biliary cholangitis (PBC). Methods A retrospective analysis was performed for the patients who were diagnosed with PBC in The Second Affiliated Hospital of Kunming ...
Original Articles_Liver Fibrosis and Liver Cirrhosis
Application value of liver stiffness measurement-to-platelet ratio index score in diagnosis of hepatitis B liver fibrosis and liver cirrhosis
Jialing ZHOU, Bingqiong WANG, Yameng SUN, Tongtong MENG, Shanshan WU, Hong MA, Xiaojuan OU, Hong YOU, Jidong JIA, Xiaoning WU
2022, 38(7): 1529-1533. DOI: 10.3969/j.issn.1001-5256.2022.07.014
Abstract(643) HTML (190) PDF (2320KB)(90)
Abstract:
Objective To investigate the diagnostic value of liver stiffness measurement-to-platelet ratio index (LPRI) score in previously untreated patients with hepatitis B liver fibrosis/liver cirrhosis, since the evaluation of liver fibrosis degree has great significance in guiding the treatment of chronic...
Effect of anti-liver fibrosis traditional Chinese medicine therapy on the prognosis of patients with liver cirrhosis and superior mesenteric venous thrombosis
Ying FENG, Ke SHI, Xiaohua ZHANG, Li YANG, Xianbo. WANG
2022, 38(7): 1534-1539. DOI: 10.3969/j.issn.1001-5256.2022.07.015
Abstract(543) HTML (123) PDF (2481KB)(50)
Abstract:
Objective To investigate the effect of anti-liver fibrosis traditional Chinese medicine (TCM) therapy on the prognosis of patients with liver cirrhosis and superior mesenteric venous thrombosis (SMVT). Methods A retrospective analysis was performed for the clinical data of 231 patients with liver ci...
Cultured mycelia of Cordyceps sinensis exerts a protective effect on a mouse model of liver fibrosis by inhibiting the Toll-like receptor 4/nuclear transcription factor-κB signaling pathway and angiopoietin-like protein 4
Linzhang ZHANG, Dingqi ZHANG, Ying XU, Hailin YANG, Shenglan QI, Congcong ZHANG, Jiamei CHEN, Ping LIU, Wei LIU
2022, 38(7): 1540-1547. DOI: 10.3969/j.issn.1001-5256.2022.07.016
Abstract(740) HTML (202) PDF (6282KB)(43)
Abstract:
Objective To investigate the interventional effect of cultured mycelia of Cordyceps sinensis on a mouse model of CCl4-induced liver fibrosis and its effect on the Toll-like receptor 4 (TLR4)/nuclear transcription factor-κB (NF-κB) pathway and angiopoietin-like protein 4 (ANGPTL4). Methods A total of...
Influence of type 2 diabetes mellitus and fasting insulin level on the risk of spontaneous peritonitis in patients with cirrhotic ascites
Xue WU, Yilian ZHANG, Ping LI, Yuqiang MI
2022, 38(7): 1548-1553. DOI: 10.3969/j.issn.1001-5256.2022.07.017
Abstract(580) HTML (179) PDF (2419KB)(46)
Abstract:
Objective To investigate the predictive factors for spontaneous bacterial peritonitis (SBP) in patients with decompensated cirrhotic ascites and the influence of type 2 diabetes mellitus (T2DM) and fasting insulin level on the risk of SBP. Methods A retrospective analysis was performed for the clini...
Value of ultrasonic shear-wave dispersion imaging in diagnosis of high-risk esophageal and gastric varices in compensated cirrhosis
Jiayin WANG, Hongyu ZHOU, Tinghong LI, Lei ZHAO, Baiguo XU, Weili YIN, Fang WANG, Jing LIANG, Xiang JING, Huiling XIANG
2022, 38(7): 1554-1560. DOI: 10.3969/j.issn.1001-5256.2022.07.018
Abstract(622) HTML (363) PDF (2530KB)(61)
Abstract:
Objective To investigate the clinical value of Canon two-dimensional ultrasound shear wave elastography (SWE) and shear wave dispersion (SWD) in the diagnosis of high-risk esophageal and gastric varices in compensated cirrhosis. Methods A total of 58 patients with compensated cirrhosis of various et...
Risk factors for the 90-day prognosis of patients with type I hepatorenal syndrome and establishment of a predictive model
Bingbing ZHU, Jinxiang YANG, Qun ZHANG, Fangyuan GAO, Xianbo WANG
2022, 38(7): 1561-1565. DOI: 10.3969/j.issn.1001-5256.2022.07.019
Abstract(416) HTML (126) PDF (2217KB)(37)
Abstract:
Objective To investigate the risk factors for the 90-day prognosis of patients with decompensated liver cirrhosis and type I hepatorenal syndrome (HRS). Methods A retrospective analysis was performed for the clinical data of 299 patients with decompensated liver cirrhosis and type I HRS who were hos...
Original Articles_Liver Neoplasms
Establishment of a nomogram model for predicting the survival of hepatitis B virus-related hepatocellular carcinoma
Songhai CHEN, Chunyan WANG, Chang GUO, Shan ZHANG, Ya DENG, Yinying LU, Dong JI
2022, 38(7): 1566-1571. DOI: 10.3969/j.issn.1001-5256.2022.07.020
Abstract(770) HTML (224) PDF (3359KB)(107)
Abstract:
Objective To investigate the risk factors for death in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), and to establish a nomogram predictive model. Methods A retrospective analysis was performed for the clinical data of 700 patients who were diagnosed with HBV-related HCC for the fi...
A prognostic analysis of transcatheter arterial chemoembolization combined with local ablation in treatment of recurrent liver cancer after surgery
Baiyu JI, Fenlin HAO, Jiangtao HAI, Junsheng ZHANG, Xiangyang WU, Dong JIN, Zhenhui LU
2022, 38(7): 1572-1576. DOI: 10.3969/j.issn.1001-5256.2022.07.021
Abstract(560) HTML (124) PDF (2058KB)(46)
Abstract:
Objective To investigate the clinical effect of transcatheter arterial chemoembolization (TACE) combined with local ablation in the treatment of recurrent liver cancer after surgery, as well as the risk factors for prognosis. Methods A retrospective analysis was performed for the data of 47 patients...
Association of programmed death-1 and programmed death-ligand 1 with the prognosis and clinical features of patients with hepatocellular carcinoma: A meta-analysis
Xin DAI, Hanlin LIU, Long CHENG, Zhulin LUO, Tao WANG
2022, 38(7): 1577-1583. DOI: 10.3969/j.issn.1001-5256.2022.07.022
Abstract(558) HTML (218) PDF (3057KB)(50)
Abstract:
Objective To systematically evaluate the influence of the expression of programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) on the prognosis of patients with hepatocellular carcinoma (HCC). Methods Related databases, such as PubMed, The Cochrane Library, Embase, CBM, CNKI, and Wanfang Da...
Original Articles_Other Liver Diseases
Clinical features of Klebsiella pneumoniae liver abscess and influencing factors for prognosis
Rui DING, Wen XIE, Ligai LIU, Qi WANG, Ying CAO
2022, 38(7): 1584-1589. DOI: 10.3969/j.issn.1001-5256.2022.07.023
Abstract(886) HTML (217) PDF (2391KB)(92)
Abstract:
Objective To investigate the clinical features of Klebsiella pneumoniae liver abscess and the influencing factors for prognosis. Methods A retrospective analysis was performed for the patients with liver abscess who were hospitalized and had positive blood culture or pus culture in Beijing Ditan Hos...
Clinical significance of ultrasound-guided percutaneous liver biopsy in the diagnosis of liver diseases
Wenxia YANG, Jingyi ZHANG, Xian YANG, Yingmei TANG
2022, 38(7): 1590-1594. DOI: 10.3969/j.issn.1001-5256.2022.07.024
Abstract(697) HTML (154) PDF (3410KB)(62)
Abstract:
Objective To investigate the disease constitution of ultrasound-guided percutaneous liver biopsy and its diagnostic efficacy in different liver diseases. Methods A total of 918 patients who underwent liver biopsy in Department of Pathology, The Second Affiliated Hospital of Kunming Medical Universit...
Original Articles_Pancreatic Diseases
Influence of fatty liver on the severity of acute pancreatitis
Miao ZHANG, Lirong ZHANG, Lin LUO, Qiang CHEN
2022, 38(7): 1595-1601. DOI: 10.3969/j.issn.1001-5256.2022.07.025
Abstract(842) HTML (271) PDF (1884KB)(46)
Abstract:
Objective To investigate the influence of fatty liver on the severity of acute pancreatitis (AP) by comparing clinical and imaging data between AP patients with fatty liver and those without fatty liver. Methods Clinical data were collected from 328 AP patients who were admitted to The First Affilia...
Guiding effect of noninvasive monitoring of cardiac output and central venous oxygen saturation on early goal-directed fluid resuscitation in hyperlipidemic severe acute pancreatitis
Hongsheng WU, Keqiang MA, Biling LIAO, Tengfei JI, Jianbin HUANG, Tiansheng CAO
2022, 38(7): 1602-1607. DOI: 10.3969/j.issn.1001-5256.2022.07.026
Abstract(576) HTML (119) PDF (1872KB)(36)
Abstract:
Objective To investigate the guiding effect of noninvasive monitoring of cardiac output (CO) and central venous oxygen saturation (ScvO2) on early goal-directed fluid resuscitation in patients with hyperlipidemic severe acute pancreatitis. Methods A total of 84 patients with hyperlipidemic severe ac...
Case Reports
Clinical cure of the non-dominant population in chronic hepatitis B patients with HBsAg>3000 IU/mL: A report of two cases
Yan HUANG, Qiongyue ZHANG, Erping LUO, Weifeng ZHAO, Jianhe GAN
2022, 38(7): 1608-1611. DOI: 10.3969/j.issn.1001-5256.2022.07.027
Abstract(827) HTML (324) PDF (2842KB)(73)
Abstract:
Conversion therapy for massive hepatocellular carcinoma: A case report
Sirou LI, Yuanlong ZHOU, Keliang LIU, Zhibo LIANG, Jinghua LI
2022, 38(7): 1612-1615. DOI: 10.3969/j.issn.1001-5256.2022.07.028
Abstract(507) HTML (171) PDF (2763KB)(47)
Abstract:
Whole genome analysis of a Wilson's disease family
Yaxin HU, Zhuo CHENG, Shuo CONG, Yongmei LIU, Baofang ZHANG, Yu LEI, Zhao YAN, Yiwei ZHANG, Xi PU, Lei YU, Mingliang CHENG
2022, 38(7): 1616-1619. DOI: 10.3969/j.issn.1001-5256.2022.07.029
Abstract(650) HTML (165) PDF (3028KB)(63)
Abstract:
Hepatopulmonary syndrome after craniopharyngioma operation in children: A case report
Tingting DU, Hui YAO, Yakun LI, Xiaoli HUANG, Jie LUO
2022, 38(7): 1620-1625. DOI: 10.3969/j.issn.1001-5256.2022.07.030
Abstract(551) HTML (147) PDF (2776KB)(47)
Abstract:
Chronic cholangitis with interstitial mucinous degeneration misdiagnosed as cholangiocarcinoma: A case report
Songsong FAN, Fang ZHANG, Lipeng YANG, Xuefeng CAO, Yanmin LU, Xingyuan ZHANG
2022, 38(7): 1626-1628. DOI: 10.3969/j.issn.1001-5256.2022.07.031
Abstract(856) HTML (244) PDF (2467KB)(32)
Abstract:
Reviews
Research advances in the immune pathogenesis of hepatitis E virus infection
Xiaoling LI, Qing ZHANG, Li'an WANG, Juanjuan ZHENG, Hai LI
2022, 38(7): 1629-1633. DOI: 10.3969/j.issn.1001-5256.2022.07.032
Abstract(672) HTML (150) PDF (2319KB)(73)
Abstract:
Hepatitis E is often acute and self-limited, but immunocompromised patients (such as solid organ transplantation recipients and patients with HIV infection or blood disease) may experience chronic infection. Immune response is the key factor for the outcome of hepatitis E virus (HEV) infection, whic...
Research advances in pharmacotherapy for nonalcoholic fatty liver disease
Rui JIN, Xiaoxiao WANG, Feng LIU, Huiying RAO
2022, 38(7): 1634-1640. DOI: 10.3969/j.issn.1001-5256.2022.07.033
Abstract(1547) HTML (2206) PDF (2729KB)(405)
Abstract:
The incidence rate of nonalcoholic fatty liver disease (NAFLD) is increasing year by year, and it gradually becomes the most common chronic liver disease in adults and children around the world. Nonalcoholic steatohepatitis (NASH) in its disease spectrum can lead to liver cirrhosis and hepatocellula...
Research advances in vitamin D deficiency and metabolic associated fatty liver disease
Ling LUO, Xianhua LIAO, Bihui ZHONG
2022, 38(7): 1641-1645. DOI: 10.3969/j.issn.1001-5256.2022.07.034
Abstract(754) HTML (396) PDF (2173KB)(65)
Abstract:
Metabolic associated fatty liver disease (MAFLD) is the largest chronic liver disease in the world. Its pathogenesis remains unclear and there is still a lack of effective drugs. This article introduces vitamin D deficiency commonly observed in patients with MAFLD, and it is pointed out that vitamin...
Assessment and clinical management of malnutrition and asthenia in patients with liver cirrhosis
Yijun ZHANG, Qian ZHANG, Xinhua LUO
2022, 38(7): 1646-1649. DOI: 10.3969/j.issn.1001-5256.2022.07.035
Abstract(924) HTML (150) PDF (1845KB)(101)
Abstract:
Malnutrition and asthenia are interrelated and multidimensional problems in patients with liver cirrhosis. Malnutrition is one of the reasons leading to asthenia, whereas asthenia is a comprehensive manifestation of functional disorders, and malnutrition and asthenia interact with each other and fur...
Clinical epidemiology and pathological features of cryptogenic cirrhosis
Rui HAN, Liaoyun ZHANG
2022, 38(7): 1650-1653. DOI: 10.3969/j.issn.1001-5256.2022.07.036
Abstract(1126) HTML (225) PDF (1850KB)(101)
Abstract:
Cryptogenic cirrhosis (CC), also known as "unexplained liver cirrhosis", refers to liver cirrhosis in some patients that cannot be explained with known causes, and CC accounts for about 5%-10% of all liver cirrhosis cases in clinical practice. This article reviews the research advances in the clinic...
Mechanism of action of the Hippo/YAP pathway in the development and progression of liver fibrosis
Xiaolu ZHAO, Chunyan ZHANG, Xiaoyang GAO, Yuehong MA
2022, 38(7): 1654-1657. DOI: 10.3969/j.issn.1001-5256.2022.07.037
Abstract(988) HTML (233) PDF (2065KB)(90)
Abstract:
Various etiologies cause the destruction of liver microenvironment, which leads to the loss of liver structure and function and initiates the process of liver fibrosis. Hepatic stellate cells (HSCs) are mainly activated into myofibroblasts that secrete a large amount of extracellular matrix (ECM), m...
Effect of the treatment modality for hepatocellular carcinoma on portal venous pressure
Bowen CHEN, Jiamin CHENG, Linzhi ZHANG, Jin LEI, Xiaoqiang GAO, Yinying LU
2022, 38(7): 1658-1661. DOI: 10.3969/j.issn.1001-5256.2022.07.038
Abstract(601) HTML (133) PDF (1848KB)(65)
Abstract:
Portal hypertension (PH) on the basis of liver cirrhosis is a common complication of hepatocellular carcinoma (HCC), and it is also a key factor affecting treatment decisions and prognosis. Different treatment modalities for HCC may have different effects on portal venous pressure. Through a literat...
Research advances in combined non-bioartificial liver in treatment of acute-on-chronic liver failure in adults
Lu WANG, Wenxiong XU, Liang PENG
2022, 38(7): 1662-1666. DOI: 10.3969/j.issn.1001-5256.2022.07.039
Abstract(641) HTML (309) PDF (2028KB)(58)
Abstract:
Acute-on-chronic liver failure (ACLF) is a common syndrome of severe liver diseases in clinical practice and has an extremely high short-term mortality rate. Non-bioartificial liver (NBAL) therapy is one of the effective treatment methods for patients with ACLF. In face of the current status of bloo...
The significance of gut microbiota in acute-on-chronic liver failure
Fuchun WANG, Ziyi LI, Wanjie ZHANG, Xiaorong MAO, Junfeng LI
2022, 38(7): 1667-1670. DOI: 10.3969/j.issn.1001-5256.2022.07.040
Abstract(725) HTML (140) PDF (2278KB)(57)
Abstract:
Various acute injury factors may act on chronic liver diseases and then lead to the rapid deterioration of disease conditions, which further develops into acute-on-chronic liver failure (ACLF). In patients with liver disease, gut microbiota toxins enter the liver through the portal vein or systemic ...
Definition, prognostic assessment, and advances in the diagnosis and treatment of acute-on-chronic liver failure
Zhanhu BI, Linxu WANG, Jianqi LIAN
2022, 38(7): 1671-1676. DOI: 10.3969/j.issn.1001-5256.2022.07.041
Abstract(1550) HTML (234) PDF (1880KB)(310)
Abstract:
Acute-on-chronic liver failure (ACLF) is a clinical syndrome with acute decompensation of liver function on the basis of chronic liver diseases, and at present, there is still no unified definition standard for this disease in the world. ACLF is characterized by rapid progression of liver disease, m...
Role of G protein-coupled receptors in liver diseases
Rui CHEN, Kun ZHANG, Beichen GUO, Yuhan LI, Wei HONG, Tao HAN
2022, 38(7): 1677-1680. DOI: 10.3969/j.issn.1001-5256.2022.07.042
Abstract(892) HTML (518) PDF (2111KB)(116)
Abstract:
Chronic liver diseases greatly threaten the health of the Chinese people, and recent studies have found that some G protein-coupled receptors (GPCRs) and related signaling pathways are involved in the physiopathological processes of the liver and are associated with various liver diseases such as no...
Research advances in the diagnostic methods for biliary atresia
Rongjuan SUN, Jianghua ZHAN
2022, 38(7): 1681-1685. DOI: 10.3969/j.issn.1001-5256.2022.07.043
Abstract(796) HTML (353) PDF (2359KB)(80)
Abstract:
For children with biliary atresia, early diagnosis and timely surgical intervention are of great importance to improve the survival rate of autologous liver. With reference to the authors' clinical experience and recent research advances, this article briefly reviews the methods for rapid diagnosis ...
Time distribution of risk factors for secondary pancreatic infection in acute pancreatitis
Chengsi ZHAO, Weijie YAO, Peng YUAN, Zuozheng WANG
2022, 38(7): 1686-1690. DOI: 10.3969/j.issn.1001-5256.2022.07.044
Abstract(813) HTML (175) PDF (2023KB)(61)
Abstract:
Pancreatic infection secondary to acute pancreatitis is an important influencing factor for the death of patients with acute pancreatitis. This article reviews the research on the risk factors for secondary pancreatic infection in acute pancreatitis in recent years and analyzes relevant risk factors...
Clinical features and management of Shwachman-Diamond syndrome
Mengping LI, Jianshe WANG, Xinbao XIE
2022, 38(7): 1691-1693. DOI: 10.3969/j.issn.1001-5256.2022.07.045
Abstract(825) HTML (172) PDF (1839KB)(65)
Abstract:
Shwachman-Diamond syndrome is an autosomal recessive disorder that may involve multiple visceral organs of the body, with the main manifestations of exocrine pancreatic insufficiency, bone marrow failure, and skeletal abnormalities with frequent liver involvement. In order to improve the awareness o...
Diagnosis and treatment of spontaneous splenic rupture associated with severe acute respiratory syndrome coronavirus 2
Hongyun SHI, Panpan QUAN, Chenglong CHU, Luyao XU, Xiaoyan LIU, Yingchao WANG
2022, 38(7): 1694-1696. DOI: 10.3969/j.issn.1001-5256.2022.07.046
Abstract(927) HTML (388) PDF (1837KB)(32)
Abstract:
Coronavirus disease 2019 (COVID-19) is an acute viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and is mainly transmitted through the respiratory tract. It not only invades the respiratory system of human body, but also damages various organs and system...
Introduction of High-quality Articles in Foreign Journals
Gastroenterology｜Postprandial plasma lipidomics reveal specific alteration of hepatic-derived diacylglycerols in nonalcoholic fatty liver disease
2022, 38(7): 1607-1607. DOI: 10.3969/j.issn.1001-5256.2022.07.gwjpwzjj1
Abstract(291) HTML (148) PDF (852KB)(30)
Abstract:
GUT｜FOXA2 prevents hyperbilirubinaemia in acute liver failure by maintaining apical MRP2 expression
2022, 38(7): 1619-1619. DOI: 10.3969/j.issn.1001-5256.2022.07.gwjpwzjj2
Abstract(303) HTML (89) PDF (856KB)(31)
Abstract:
Liver International｜Epidemic characteristics of alcohol-related liver disease in Asia from 2000-2020: a systematic review and meta-analysis
2022, 38(7): 1625-1625. DOI: 10.3969/j.issn.1001-5256.2022.07.gwjpwzjj3
Abstract(463) HTML (128) PDF (852KB)(47)
Abstract:
Thanks
Current reviewers
2022, 38(7): 1468-1468. DOI: 10.3969/j.issn.1001-5256.2022.07.zhixie1
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Abstract:
    

The first journal specializing in hepatobiliary and pancreatic diseases in China

Supervisor：Ministry of Education of the People's Republic of China

Sponsor：Jilin University

Academic Support: Chinese Society of Hepatology，Chinese Medical Association

Address: 461 Xinjiang Road, Changchun

Submit：0431-88782044

Peer review：0431-88783542

Email：lcgdb@vip.163.com

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