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ISSN 2097-3497 (Online)
CN 22-1108/R
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2022 No.12
Theme Issue: Diagnosis and treatment of pancreatic diseases
Executive Chief Editor: ZHANG Shutian 
Beijing Friendship Hospital,Capital Medical University
Cover Content

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Editorial
Application of endoscopic ultrasound in the diagnosis and treatment of pancreatic diseases
Yuanzhen HAO, Rui CHENG, Shutian ZHANG
2022, 38(12): 2681-2686. DOI: 10.3969/j.issn.1001-5256.2022.12.001
Abstract(1816) HTML (1029) PDF (1978KB)(155)
Abstract:
In recent years, endoscopic ultrasound gradually plays a more and more important role in the diagnosis and rescue treatment of pancreatic diseases due to its accuracy in localization and minimally invasive operation. With the continuous development and improvement of various surgical procedures, the...
Discussions by Experts
Advances in endoscopic retrograde cholangiopancreatography in diagnosis and treatment of pancreatic diseases in children
Xiaoping ZOU
2022, 38(12): 2687-2692. DOI: 10.3969/j.issn.1001-5256.2022.12.002
Abstract(1637) HTML (1009) PDF (2058KB)(86)
Abstract:
Pancreatic diseases in children mainly include chronic pancreatitis caused by congenital abnormal development and pancreatic duct rupture due to trauma. In recent years, endoscopic retrograde cholangiopancreatography (ERCP) has gradually become the most important method for the diagnosis and treatme...
Minimally invasive surgical treatment of local complications of acute pancreatitis
Zhen FANG, Fei LI
2022, 38(12): 2693-2695. DOI: 10.3969/j.issn.1001-5256.2022.12.003
Abstract(1663) HTML (1056) PDF (1857KB)(92)
Abstract:
Acute pancreatitis (AP) is a common acute abdominal disease of the digestive system, with an increasing incidence rate in recent years. Pancreatic necrosis and its secondary complications are important causes of death in AP patients. With the continuous development of minimally invasive medicine, su...
Function-preserving laparoscopic pancreatic surgery: A reasonable choice in pancreatic surgery
Chengqing LI, Lei WANG
2022, 38(12): 2696-2700. DOI: 10.3969/j.issn.1001-5256.2022.12.004
Abstract(1862) HTML (1159) PDF (1879KB)(128)
Abstract:
With the improvement of diagnostic techniques, the diagnostic rate of pancreatic tumors has increased significantly, with a tendency of an earlier age of onset. Since the pancreas is an important endocrine organ, the loss of pancreatic function will have a serious impact on the quality of life of pa...
Guidelines
Expert consensus on liver transplantation perioperative evaluation and rehabilitation for acute-on-chronic liver failure
Transplantation Immunology Committee of Branch of Organ Transplantation Physician of Chinese Medical Doctor Association, Organ Transplant Rehabilitation Committee of China Association Rehabilitation Medicine, Branch of Organ Transplantation Physician of Guangdong Medical Doctor Association
2022, 38(12): 2701-2708. DOI: 10.3969/j.issn.1001-5256.2022.12.005
Abstract(1604) HTML (968) PDF (1949KB)(90)
Abstract:
Acute-on-chronic liver failure (ACLF) can be cured by liver transplantation; however, perioperative complications still affect posttransplant outcomes. In recent years, early rehabilitation for critical illness, liver disease, and surgery have significantly improved organ reserve function, surgery t...
Key points of AASLD practice guidance for the diagnosis and treatment of Wilson's disease (2022)
Wei ZHANG, Jian HUANG, Xiaojuan OU, Jidong JIA
2022, 38(12): 2709-2711. DOI: 10.3969/j.issn.1001-5256.2022.12.006
Abstract(1880) HTML (1162) PDF (2141KB)(168)
Abstract:
Recommendations for EASL Clinical Practice Guidelines on the management of cystic liver diseases (2022)
Hangying REN, Ke REN
2022, 38(12): 2712-2715. DOI: 10.3969/j.issn.1001-5256.2022.12.007
Abstract(1967) HTML (1223) PDF (3022KB)(288)
Abstract:
Original Articles_Viral Hepatitis
Influencing factors for low-level viremia and their dynamic changes in patients with chronic hepatitis B treated with nucleos(t)ide analogues for the first time
Qiqi CHENG, Lixia YANG, Tianpan CAI, Liang WANG, Jun SUN, Jiayuan LIANG, Liping LIU, Xia GAN, Ninghang RUAN, Shanfei GE
2022, 38(12): 2716-2722. DOI: 10.3969/j.issn.1001-5256.2022.12.008
Abstract(1827) HTML (1037) PDF (2326KB)(117)
Abstract:
Objective To investigate the influencing factors for low-level viremia (LLV) and their dynamic changes in chronic hepatitis B (CHB) patients treated with nucleos(t)ide analogues (NAs) for the first time. Methods A retrospective analysis was performed for 78 CHB patients who attended Department of In...
Original Articles_Fatty Liver Diseases
Association of fat mass- and obesity-associated gene (FTO) polymorphisms with susceptibility to nonalcoholic fatty liver disease
Lei MA, Anhua HAO, Xinxin HU, Zhenzhen ZHAO, Lin ZHOU, Yongning XIN
2022, 38(12): 2723-2727. DOI: 10.3969/j.issn.1001-5256.2022.12.009
Abstract(1722) HTML (1021) PDF (1892KB)(80)
Abstract:
Objective To investigate the relationship between Fat Mass- and obesity-associated gene (FTO) polymorphisms and the susceptibility of non-alcohol-related fatty liver disease (NAFLD) in a Han population from Qingdao region of China. Methods A total of 119 NAFLD patients were recruited from Qingdao Mu...
Effects of Xuefu Zhuyu decoction and its extracts on a mouse model of nonalcoholic fatty liver disease induced by high-fat diet
Hao TANG, Yixiao YIN, Wei LIU, Yi FANG, Jun WANG, Yiyang HU, Jinghua PENG
2022, 38(12): 2728-2737. DOI: 10.3969/j.issn.1001-5256.2022.12.010
Abstract(2045) HTML (1499) PDF (4784KB)(99)
Abstract:
Objective To investigate the effect of Xuefu Zhuyu decoction on nonalcoholic fatty liver disease (NAFLD) and its material basis. Methods In experiment 1 for exploring the effect of Xuefu Zhuyu decoction on mice with NAFLD induced by high-fat diet, 50 healthy male C57BL/6J mice were randomly divided ...
Original Articles_Autoimmune Liver Diseases
Occult HBV infection in autoimmune hepatitis and its influence on disease progression
Xinxin CHEN, Haiping ZHANG, Chunyang HUANG, Jianrong SU, Huiping YAN
2022, 38(12): 2738-2743. DOI: 10.3969/j.issn.1001-5256.2022.12.011
Abstract(2008) HTML (1053) PDF (2424KB)(106)
Abstract:
Objective To investigate the prevalence rate of occult HBV infection (OBI) in patients with autoimmune hepatitis (AIH) and the influence of OBI in the clinical condition and prognosis of AIH patients. Methods A total of 103 patients with a confirmed diagnosis of AIH who were admitted to Beijing YouA...
Liver histopathology and clinical features of autoimmune hepatitis with different antibody statuses
Yuanjiao GAO, Yanjie LIN, Liu YANG, Xiaoyue BI, Wen DENG, Tingting JIANG, Fangfang SUN, Yao LU, Lu ZHANG, Minghui LI, Yao XIE
2022, 38(12): 2744-2749. DOI: 10.3969/j.issn.1001-5256.2022.12.012
Abstract(1672) HTML (1001) PDF (1908KB)(109)
Abstract:
Objective To compare clinical and pathological features between autoimmune hepatitis (AIH) patients with positive and negative autoantibodies, and to summarize the experience in diagnosis. Methods A retrospective analysis was performed for the patients who attended Beijing Ditan Hospital from Januar...
Original Articles_Liver Fibrosis and Liver Cirrhosis
Value of von Willebrand factor antigen-to-albumin ratio and glycocalicin index in predicting esophageal varices in hepatitis B cirrhosis
Caijun HAN, Yuan HUANG, Bin NIAN, Meihua PIAO
2022, 38(12): 2750-2754. DOI: 10.3969/j.issn.1001-5256.2022.12.013
Abstract(1577) HTML (1033) PDF (2647KB)(62)
Abstract:
Objective To investigate the clinical value of von Willebrand factor antigen-to-albumin ratio (VAR) score and glycocalicin index (GCI) score in predicting the development and classification of esophageal varices in comparison with von Willebrand factor antigen-to-platelet ratio (VITRO) score. Method...
Original Articles_Liver Neoplasms
Efficacy and safety of transarterial chemoembolization combined with camrelizumab and apatinib in treatment of advanced hepatocellular carcinoma
Yihan YANG, Wanci LI, Binyan ZHONG, Jian SHEN, Xiaoli ZHU
2022, 38(12): 2755-2760. DOI: 10.3969/j.issn.1001-5256.2022.12.014
Abstract(1869) HTML (996) PDF (2481KB)(96)
Abstract:
Objective To investigate the efficacy and safety of transarterial chemoembolization (TACE) combined with camrelizumab and apatinib in the treatment of advanced hepatocellular carcinoma (HCC). Methods From July 2019 to June 2021, 19 patients with advanced HCC who met the inclusion and exclusion crite...
Effectiveness and safety of programmed cell death-1 inhibitor in the treatment of advanced non-HBV non-HCV-related hepatocellular carcinoma
Haonan LIU, Yuqin WANG, Meng WU, Tong LU, Yang ZHAO, Zhengxiang HAN
2022, 38(12): 2761-2766. DOI: 10.3969/j.issn.1001-5256.2022.12.015
Abstract(1705) HTML (982) PDF (1945KB)(64)
Abstract:
Objective To investigate the clinical effectiveness and adverse events of domestic programmed cell death -1 (PD-1) inhibitor in the treatment of advanced non-HBV non-HCV-related hepatocellular carcinoma (NBNC-HCC). Methods A totals of 31 patients with advanced NBNC-HCC who received domestic PD-1 inh...
Original Articles_Pancreatic Diseases
Clinical effect of fecal microbiota transplantation versus the traditional Chinese medicine Rheum officinale in a rat model of hyperlipidemic acute pancreatitis
Xujuan LUO, Xue BAI, Zenghui LI, Fan LIU, Hao TANG, Ruoxin LI, Guodong YANG
2022, 38(12): 2767-2773. DOI: 10.3969/j.issn.1001-5256.2022.12.016
Abstract(1786) HTML (964) PDF (3051KB)(62)
Abstract:
Objective To investigate the effect of fecal microbiota transplantation (FMT) on a rat model of hypertriglyceridemic acute pancreatitis (HLAP). Methods A total of 72 male Sprague-Dawley rats were randomly divided into sham-operation group, model group, Rheum officinale group, and fecal microbiota gr...
Value of 18F-FDG PET/CT, contrast-enhanced ultrasound, and their combined use in differential diagnosis of benign and malignant pancreatic lesions: A comparative study
Lichun ZHENG, Xiaoming ZHANG, Tianying YU, Jie LI, Xiaoqian DENG, Xiangliu OUYANG
2022, 38(12): 2774-2779. DOI: 10.3969/j.issn.1001-5256.2022.12.017
Abstract(1797) HTML (1272) PDF (3391KB)(42)
Abstract:
Objective To assess the value of 18F-FDG PET/CT, contrast-enhanced ultrasound, and their combination in the differential diagnosis of benign and malignant pancreatic lesions. Methods A retrospective analysis was performed on patients with pancreatic lesions who underwent18F-FDG PET/CT and contrast-e...
Clinical characteristics of patients with pancreatic cancer combined with new onset diabetes mellitus
Qian ZHAO, Yongliang FENG, Yan WANG, Zhigang WEI
2022, 38(12): 2780-2786. DOI: 10.3969/j.issn.1001-5256.2022.12.018
Abstract(1562) HTML (1110) PDF (1916KB)(64)
Abstract:
Objective To investigate the clinical characteristics of patients with pancreatic cancer (PC) complicated with new-onset diabetes mellitus (DM), and to provide a basis for defining a high-risk group for PC. Methods The 426 PC cases admitted to the First Hospital of Shanxi Medical University from Jan...
Risk factors for myocardial injury after Nano-Knife surgery in patients with pancreatic cancer
Longzhu HAI, Qiangfu HU, Xiaoyong LI, Peilei GUO, Lingwei YANG
2022, 38(12): 2787-2792. DOI: 10.3969/j.issn.1001-5256.2022.12.019
Abstract(1534) HTML (1055) PDF (1912KB)(43)
Abstract:
Objective To investigate the risk factors for myocardial injury after Nano-Knife surgery in patients with pancreatic cancer, and to establish a nomogram model for risk prediction. Methods A retrospective analysis was performed for the clinical data of 92 patients with pancreatic cancer who underwent...
Mechanism of carrimycin in regulating the biological function of pancreatic cancer cells
Lina BAI, Ying LIU, Chunxiao TANG, Hongxin PIAO, Zhenhua LIN, Wanshan YANG, Aihua JIN
2022, 38(12): 2793-2801. DOI: 10.3969/j.issn.1001-5256.2022.12.020
Abstract(1722) HTML (1021) PDF (6790KB)(65)
Abstract:
Objective To investigate the effect of carrimycin on the biological function of pancreatic cancer cells. Methods Pancreatic cancer cell lines MIA PaCa-2, BxPC-3, Panc-1, and PATU 8988 were treated with carrimycin at concentrations of 0 (control group), 2, 4, 8, and 16 μmol/L for 24, 48, and 72 hours...
Clinical significance of FAT4 protein expression in pancreatic cancer
Yao ZHANG, Kai ZHANG, Chao MA
2022, 38(12): 2802-2806. DOI: 10.3969/j.issn.1001-5256.2022.12.021
Abstract(1484) HTML (967) PDF (2898KB)(39)
Abstract:
Objective To detect the expression of fat atypical cadherin 4 (FAT4) in pancreatic cancer tissue and para-carcinoma tissue, and explored the role of FAT4 in the pathogenesis of pancreatic cancer. Methods Pancreatic cancer tissue samples and adjacent tissue samples were collected from 79 patients who...
Value of pancreatic anatomic structure under standard pancreatic neck transection in predicting pancreatic fistula after pancreaticoduodenectomy
Lichen ZHOU, Zhen TAN, Yaping TANG, Zhirong ZHAO, Ruiwu DAI
2022, 38(12): 2807-2813. DOI: 10.3969/j.issn.1001-5256.2022.12.022
Abstract(1600) HTML (979) PDF (2420KB)(53)
Abstract:
Objective To investigate and validate the effect of relevant parameters of pancreatic anatomic structure under standard pancreatic neck transection in predicting postoperative pancreatic fistula (POPF). Methods A total of 140 patients who underwent pancreaticoduodenectomy (PD) in The General Hospita...
Brief Reports
Analysis of Wilson's disease presented with osteoarticular symptoms in 14 patients
Chengwei KANG, Hongyun WO, Changchao DONG, Zhaokui YAN, Xiaobing PU
2022, 38(12): 2814-2817. DOI: 10.3969/j.issn.1001-5256.2022.12.023
Abstract(1571) HTML (1012) PDF (2109KB)(57)
Abstract:
Case Reports
Diagnosis and treatment of hepatic pseudoaneurysm with bile leakage and bile duct hemorrhage after transplantation of donor liver with right hepatic artery variation: A case report
Tian HAN, Rui ZHANG, Zhiyong SHI, Li ZHANG, Jun XU
2022, 38(12): 2818-2820. DOI: 10.3969/j.issn.1001-5256.2022.12.024
Abstract(1455) HTML (966) PDF (2268KB)(47)
Abstract:
Diffuse large B-cell lymphoma with severe cholestasis as the main manifestation: A case report
Huaqian XU, Meng WEI, Xue ZHANG, Hai YI, Fangyi FAN, Aiping HUANG, Shanhong TANG
2022, 38(12): 2821-2823. DOI: 10.3969/j.issn.1001-5256.2022.12.025
Abstract(1611) HTML (946) PDF (2629KB)(78)
Abstract:
Autoimmune pancreatitis involving left iliac paravascular tissue: A case report
Xin YANG, Lamei LI, Qi ZHU, Xinle YANG, Xinrui WANG, Yanjun CAI, Wanyu LI
2022, 38(12): 2824-2826. DOI: 10.3969/j.issn.1001-5256.2022.12.026
Abstract(1433) HTML (953) PDF (2345KB)(66)
Abstract:
Ectopic pancreas in duodenal ampullary: A case report
Hongyun SHI, Panpan QUAN, Xiangyang SONG, Xiaoyan LIU, Yingchao WANG
2022, 38(12): 2827-2829. DOI: 10.3969/j.issn.1001-5256.2022.12.027
Abstract(1473) HTML (990) PDF (2454KB)(63)
Abstract:
Reviews
Clinical significance and methods of hepatitis D virus RNA detection
Yanxue LIN, Yanli QIN, Jiming ZHANG
2022, 38(12): 2830-2835. DOI: 10.3969/j.issn.1001-5256.2022.12.028
Abstract(1664) HTML (1192) PDF (1914KB)(128)
Abstract:
The prevalence and severity of hepatitis D virus (HDV) infection have always been underestimated, and the low screening and diagnosis rates may bring severe disease burden. HDV RNA, as the direct evidence of viral replication, is of great importance for the diagnosis and management of hepatitis D. T...
Protective mechanism of interleukin-10 against nonalcoholic fatty liver disease and its prospect in treatment
Ruifeng LI, Tingni ZONG, Guangrong DAI
2022, 38(12): 2836-2840. DOI: 10.3969/j.issn.1001-5256.2022.12.029
Abstract(1883) HTML (986) PDF (2118KB)(126)
Abstract:
With the prevalence of obesity and metabolic syndrome, nonalcoholic fatty liver disease (NAFLD) has become the largest chronic liver disease in China. However, the pathogenesis of NAFLD remains unclear, and recent studies have found that interleukin-10 (IL-10) not only plays an important role in the...
Advances in the mechanism of action of silent information regulator 1 in alcoholic liver disease and related pharmaceutical studies
Tiantian LIU, Jiangkai LIU, Suling LI, Liang LIU, Yaru ZHANG, Jianwen ZHANG, Bingqian LI
2022, 38(12): 2841-2845. DOI: 10.3969/j.issn.1001-5256.2022.12.030
Abstract(1907) HTML (996) PDF (2307KB)(81)
Abstract:
Alcoholic liver disease (ALD) is one of the main chronic liver diseases in the world, and the prevalence rate of ALD is increasing year by year in China, with a trend of earlier age of onset. Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase and play...
Research progress in nutritional support for liver cirrhosis patients
Yumei HE, Liping WU, Zhiming WANG, Menghao HAO, Ling HU, Jiazhen LI, Xiaobin SUN
2022, 38(12): 2846-2849. DOI: 10.3969/j.issn.1001-5256.2022.12.031
Abstract(1980) HTML (1001) PDF (1888KB)(189)
Abstract:
Malnutrition in liver cirrhosis is associated with ascites, hepatic encephalopathy, infection, and other complications even death. To date, the hazard and disease burden of malnutrition in cirrhosis patients have been severely underestimated. This review summarized the most recent advancement in the...
Porto-sinusoidal vascular disease——A novel entity of portal hypertension
Yulin LI, Yanqiu FU, Lishi ZHOU, Yufu LI, Dongye YANG
2022, 38(12): 2850-2854. DOI: 10.3969/j.issn.1001-5256.2022.12.032
Abstract(2428) HTML (1014) PDF (1896KB)(188)
Abstract:
Porto-sinusoidal vascular disease (PSVD) is an entity characterized with portal hypertension (PH) in the absence of cirrhosis, the related risk factors, and imaging evidence of obstructed portal vein, hepatic vein and inferior vena cava. Its prevalence varies significantly between East and West coun...
Advances in application of transarterial chemoembolization combined with targeted therapy/immunotherapy in advanced hepatocellular carcinoma
Xiaohui ZHAO, Quanjun YAO, Hailiang LI, Hongtao HU
2022, 38(12): 2855-2858. DOI: 10.3969/j.issn.1001-5256.2022.12.033
Abstract(1599) HTML (986) PDF (1890KB)(107)
Abstract:
Most of the patients with hepatocellular carcinoma (HCC) in China are in the advanced stage at the time of diagnosis, and the treatment methods for HCC mainly include transarterial chemoembolization and systemic therapy. This article introduces the targeted drugs represented by sorafenib and lenvati...
Macrophage depletion and its application in liver injury
Qian YU, Sai ZHAO, Liangming LIU
2022, 38(12): 2859-2863. DOI: 10.3969/j.issn.1001-5256.2022.12.034
Abstract(2069) HTML (1585) PDF (2135KB)(130)
Abstract:
Macrophages are a heterogeneous cell population involved in tissue homeostasis, inflammation, and various pathophysiological processes. Selective clearance of macrophages in vivo is a widely accepted method used to investigate whether macrophages are involved in any specific biological regulatory me...
Application of proton pump inhibitors in acute-on-chronic liver failure
Yuhao YAO, Xiao XIA, Jiaxin ZHANG, Xiaoke LI, Yong'an YE
2022, 38(12): 2864-2867. DOI: 10.3969/j.issn.1001-5256.2022.12.035
Abstract(1721) HTML (974) PDF (1884KB)(104)
Abstract:
Proton pump inhibitors (PPIs) are commonly used in clinical practice and are currently widely used in people with acute-on-chronic liver failure (ACLF). However, such medication is still not supported by the recommendations in the latest version of Clinical guidelines for acute-on-chronic liver fail...
Application progress of transpapillary biliary drainage in endoscopic treatment of choledocholithiasis
Ao WANG, Ning LI
2022, 38(12): 2868-2872. DOI: 10.3969/j.issn.1001-5256.2022.12.036
Abstract(1594) HTML (965) PDF (1900KB)(58)
Abstract:
Transpapillary biliary drainage is important for the endoscopic treatment of choledocholithiasis and its complications. The benefits of various drainage approaches are worth considering. This article discusses the benefits and drawbacks of endoscopic nasobiliary drainage (ENBD) and endoscopic retrog...
Advances in the application of ultrasound in the diagnosis and treatment of acute pancreatitis
Pan LIU, Liang HAO, Yu CHENG, Beibei YANG, Yong WEI, Zhenhong XIA, Shoujun YU
2022, 38(12): 2873-2876. DOI: 10.3969/j.issn.1001-5256.2022.12.037
Abstract(1697) HTML (984) PDF (1879KB)(49)
Abstract:
Acute pancreatitis is a common acute abdominal disease of the digestive system characterized by multiple etiologies and rapid progression, and early diagnosis and treatment are closely associated with the prognosis of patients. Among various radiological examinations, ultrasound can perform real-tim...
Research advances in the value of related markers in predicting the severity and prognosis of acute pancreatitis
Qiu JIN, Jing YANG, Honglin MA, Pingju LI, Shaoshan HU, Qingqing LIU
2022, 38(12): 2877-2881. DOI: 10.3969/j.issn.1001-5256.2022.12.038
Abstract(1849) HTML (994) PDF (1914KB)(78)
Abstract:
Acute pancreatitis (AP) is a common acute abdominal disease in gastroenterology. Severe patients tend to have high mortality and poor prognosis, and early evaluation of disease conditions and prediction of clinical outcome is of particular importance to improve the prognosis of patients. In recent y...
Association between pancreatic cancer and diabetes
Shengchen NAN, Qiao SHI, Chen CHEN, Weixing WANG
2022, 38(12): 2882-2886. DOI: 10.3969/j.issn.1001-5256.2022.12.039
Abstract(2654) HTML (1157) PDF (2060KB)(89)
Abstract:
Pancreatic cancer is a type of highly malignant digestive system tumor, with a 5-year overall survival rate of < 10%. In recent years, a large number of studies have shown that there is a two-way relationship between pancreatic cancer and diabetes; diabetes is not only one of the high-risk factor...
Research advances in the mechanism of metabolic communication between peripheral nerves and pancreatic cancer cells
Gengzhou TIAN, Lei ZOU
2022, 38(12): 2887-2891. DOI: 10.3969/j.issn.1001-5256.2022.12.040
Abstract(1550) HTML (1076) PDF (2129KB)(75)
Abstract:
The metabolism of various substances is interconnected in tumor microenvironment, and the interaction of metabolic signaling pathways forms a complex metabolic network, which together maintains the homeostasis of tumor microenvironment. Peripheral nerves, which consist of the nerve trunks, plexus, g...
Role of transforming growth factor-β in the development and progression of pancreatic cancer
Hao ZHANG, Linxun LIU, Zhanxue ZHAO, Hongshuai PAN, Xiaofan HOU, Zheng HUO
2022, 38(12): 2892-2896. DOI: 10.3969/j.issn.1001-5256.2022.12.041
Abstract(1526) HTML (1154) PDF (2378KB)(60)
Abstract:
Pancreatic ductal adenocarcinoma has a high degree of malignancy, an insidious onset, and rapid progression, with no obvious abdominal manifestations and signs in the early stage. Most patients are already in the advanced stage and have distant organ metastasis at the time of diagnosis, and thus sur...
Numb and its alternative splicing in pancreatic cancer
Penghao LI, Kailian ZHENG, Xiongfei XU, Gang JIN
2022, 38(12): 2897-2900. DOI: 10.3969/j.issn.1001-5256.2022.12.042
Abstract(1503) HTML (1000) PDF (1884KB)(36)
Abstract:
Pancreatic cancer, a common digestive system tumor with high malignancy and a poor prognosis, has several treatment options. However, none of them are particularly effective because understanding the pathogenesis of pancreatic cancer remains a significant clinical challenge. Splicing isoforms mediat...
Role of KRAS mutation in metabolism of pancreatic ductal adenocarcinoma
Yi CHEN, Li XIE, Jian WU
2022, 38(12): 2901-2907. DOI: 10.3969/j.issn.1001-5256.2022.12.043
Abstract(2065) HTML (1614) PDF (3776KB)(188)
Abstract:
Pancreatic cancer is a malignant tumor with high fatality rate and poor prognosis, and gene mutations involved in tumor metabolism are considered as the basis of its progression and poor prognosis. Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer, and it is report...
Comparison and selection of animal models of pancreatic cancer
Zhangli YAN, Xiaofan XU, Jiaqi XIN, Hong ZHANG
2022, 38(12): 2908-2912. DOI: 10.3969/j.issn.1001-5256.2022.12.044
Abstract(1657) HTML (2223) PDF (2109KB)(183)
Abstract:
Pancreatic cancer (PC) has the characteristics of insidious onset, rapid progression, and poor prognosis. Up to now, there are no standard clinical regimens for the treatment of PC, and the benefit rate of new targeted therapy remains at a relatively low level, which results in the high mortality ra...
Introduction of High-quality Articles in Foreign Journals
Journal of Hepatology｜Impact of HBsAg seroclearance on late recurrence of hepatitis B virus-related hepatocellular carcinoma after surgical resection
2022, 38(12): 2727-2727. DOI: 10.3969/j.issn.1001-5256.2022.12.gwjpwzjj1
Abstract(1398) HTML (968) PDF (888KB)(67)
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Journal of Hepatology｜Severity of systemic inflammation is the main predictor of ACLF and bleeding in individuals with acutely decompensated cirrhosis
2022, 38(12): 2766-2766. DOI: 10.3969/j.issn.1001-5256.2022.12.gwjpwzjj2
Abstract(1393) HTML (1011) PDF (881KB)(80)
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Journal of Hepatology｜Prognostic and therapeutic significance of microbial cell-free DNA in plasma of people with acutely decompensated cirrhosis
2022, 38(12): 2876-2876. DOI: 10.3969/j.issn.1001-5256.2022.12.gwjpwzjj3
Abstract(1360) HTML (940) PDF (886KB)(61)
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Thanks
Current reviewers
2022, 38(12): 2695-2695. DOI: 10.3969/j.issn.1001-5256.2022.12.zhixie1
Abstract(1255) HTML (913) PDF (872KB)(31)
Abstract:
    

The first journal specializing in hepatobiliary and pancreatic diseases in China

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