中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

2020 Vol. 36, No. 2

Display Method:
Editorial
Downstaging and conversion treatment of intermediate and advanced liver cancer should be taken seriously
Ye ShengLong
2020, 36(2): 249-251. DOI: 10.3969/j.issn.1001-5256.2020.02.001
Abstract(1560) PDF (2015KB)(394) Cited By (12)
Abstract:

Surgical treatment is the most effective approach to achieving radical treatment and long-term survival of liver cancer. At present,most patients with intermediate and advanced liver cancer do not have the opportunity to receive radical surgery. The downstaging and conversion treatment strategies fo...

Discussions by experts
Conversion therapy for hepatocellular carcinoma: Strategies and methods
Yuan ShengXian, Zhou WeiPing
2020, 36(2): 252-257. DOI: 10.3969/j.issn.1001-5256.2020.02.002
Abstract(1451) PDF (1988KB)(355) Cited By (7)
Abstract:

Surgery is the most important radical treatment for hepatocellular carcinoma( HCC),but less than 30% of HCC patients have the chance for radical surgery at initial diagnosis. How to transform unresectable tumor into the candidate of radical resection becomes an important way to improve the survival ...

Radiotherapy for hepatocellular carcinoma downstaging: From palliative care to radical treatment
Zeng ZhaoChong, Sun JianGuo, Lang JinYi
2020, 36(2): 258-262. DOI: 10.3969/j.issn.1001-5256.2020.02.003
Abstract(1321) PDF (3179KB)(284) Cited By (4)
Abstract:

The purpose of tumor staging is to guide treatment,and the treatment for a certain stage should be adjusted based on the changes in disease condition,in order to facilitate better control of tumor. Therefore,the treatment of liver cancer requires follow-up and re-staging to develop better treatment ...

Downstaging treatment of hepatocellular carcinoma with portal vein tumor thrombus
Cheng ShuQun, Wei XuBiao
2020, 36(2): 263-266. DOI: 10.3969/j.issn.1001-5256.2020.02.004
Abstract(1205) PDF (1951KB)(333) Cited By (10)
Abstract:

Hepatocellular carcinoma with portal vein tumor thrombus has a high incidence rate and rapid progression,and there are limited therapies with a poor clinical effect. Although sorafenib is recommended as the sole therapy for such patients in foreign guidelines,studies have shown that some patients ma...

Downstaging conversion therapy for advanced primary liver cancer
Yuan XiangLin
2020, 36(2): 267-271. DOI: 10.3969/j.issn.1001-5256.2020.02.005
Abstract(1685) PDF (1966KB)(403) Cited By (20)
Abstract:

Most patients with primary liver cancer in China are in the advanced stage at initial diagnosis and lose the opportunity for surgical treatment,and therefore,how to reduce advanced liver cancer to resectable liver cancer is a hot topic in clinical research in recent years.The key premise of successf...

Role of interventional therapy in the downstaging of advanced liver cancer
Lu Jian, Zhu HaiDong, Teng GaoJun, Wang Zhi
2020, 36(2): 272-276. DOI: 10.3969/j.issn.1001-5256.2020.02.006
Abstract(1181) PDF (1976KB)(282) Cited By (7)
Abstract:

Interventional therapy has become an important palliative therapy for advanced liver cancer,and meanwhile,interventional therapy is playing an important role in the downstaging of liver cancer. Local interventional therapy can help patients meet the criteria for transplantation or resection by reduc...

Guidelines
Guidelines for diagnosis and treatment of primary liver cancer in China (2019 edition)
Bureau of Medical Administration, National Health Commission of the People’s Republic of China
2020, 36(2): 277-292. DOI: 10.3969/j.issn.1001-5256.2020.02.007
Abstract(1336) PDF (1468KB)(1370) Cited By (255)
Abstract:
An excerpt of EASL clinical practice guideline: Occupational liver diseases (2019)
Li Fan, Wang Shuai
2020, 36(2): 293-298. DOI: 10.3969/j.issn.1001-5256.2020.02.008
Abstract:
Academic contention
Seeking truth from facts is the virtue of scientific workers——Response to the reply from Professors Zhao Yingren and Chen Yaolong
Li Tong, Cui FuQiang, Zhou YiHua, Xiang KuanHui, Zhuang Hui
2020, 36(2): 299-300. DOI: 10.3969/j.issn.1001-5256.2020.02.009
Abstract:
Comments on the recommendations for unintended pregnancy during antiviral therapy in women of childbearing age in 2019 Chinese practice guideline for the prevention and treatment of hepatitis B virus mother-to-child transmission
Xian JianChun, Zhou YiHua
2020, 36(2): 301-302. DOI: 10.3969/j.issn.1001-5256.2020.02.010
Abstract(345) PDF (139KB)(134) Cited By (1)
Abstract:
A second discussion on 2019 Chinese practice guideline for the prevention and treatment of hepatitis B virus motherto-child transmission: Evidence,evidence,and always evidence
Ding Yang, Dou XiaoGuang
2020, 36(2): 303-304. DOI: 10.3969/j.issn.1001-5256.2020.02.011
Abstract(355) PDF (129KB)(134) Cited By (2)
Abstract:
Hepatitis B vaccine immunization is the key strategy for prevention of HBV mother-to-child transmission——Comments on 2019 Chinese practice guideline for the prevention and treatment of hepatitis B virus mother-to-child transmission
Cui FuQiang
2020, 36(2): 305-306. DOI: 10.3969/j.issn.1001-5256.2020.02.012
Abstract(394) PDF (418KB)(203) Cited By (10)
Abstract:
Several opinions on 2019 Chinese practice guideline for the prevention and treatment of hepatitis B virus mother-to-child transmission
Wang DeYang
2020, 36(2): 307-307. DOI: 10.3969/j.issn.1001-5256.2020.02.013
Abstract:
My opinion on release of guidelines
Hu YaoRen
2020, 36(2): 308-308. DOI: 10.3969/j.issn.1001-5256.2020.02.014
Abstract:
Original articles_Viral hepatitis
Distribution characteristics of hepatitis C virus genotypes in Guizhou,China
Wang Mei, Yang XingLin, Zhang Liu, Wang Jun, Wang Yi
2020, 36(2): 309-313. DOI: 10.3969/j.issn.1001-5256.2020.02.015
Abstract(1085) PDF (1984KB)(216) Cited By (7)
Abstract:

ObjectiveTo investigate the distribution characteristics of hepatitis C virus (HCV) genotypes in patients with hepatitis C in Guizhou, China, and to provide a basis for the prevention and individualized treatment of HCV infection. MethodsA total of 1211 HCV RNA-positive patients with hepatitis C who...

Original articles_Liver fibrosis and liver cirrhosis
Association between the reduction in liver stiffness measurement and the histological outcome of liver fibrosis regression in patients with chronic hepatitis B
Kong YuanYuan, Sun YaMeng, Zhou JiaLing, Wu XiaoNing, Ma Hong, Ou XiaoJuan, Jia JiDong, You Hong
2020, 36(2): 314-318. DOI: 10.3969/j.issn.1001-5256.2020.02.016
Abstract(1830) PDF (2028KB)(631) Cited By (22)
Abstract:

Objective To investigate the association between the change in liver stiffness measurement( LSM) and the histological outcome of liver fibrosis in patients with chronic hepatitis B( CHB) during antiviral therapy. Methods In a prospective cohort of CHB patients receiving entecavir-based therapy( from...

The anti-liver fibrosis effect of Kangxian Ruangan prescription: A cell study based on hepatic sinusoidal capillarization
Xu Jie, Liu Yan, Lou WangZhouYang, Xu Jun, Qi Lu, Cheng LiangBin
2020, 36(2): 319-323. DOI: 10.3969/j.issn.1001-5256.2020.02.017
Abstract(1321) PDF (2259KB)(225) Cited By (16)
Abstract:

Objective To investigate the anti-liver fibrosis effect and mechanism of action of Kangxian Ruangan prescription based on hepatic sinusoidal capillarization. Methods A total of 16 male Wistar rats were divided into Kangxian Ruangan prescription group and control group,with 8 rats in each group. The ...

Glucose metabolism and insulin secretion in patients with chronic hepatitis B cirrhosis of different Child-Pugh grades and their association with inflammatory response
Liu Li, Jiang YingYi, Liu Jing
2020, 36(2): 324-328. DOI: 10.3969/j.issn.1001-5256.2020.02.018
Abstract(1261) PDF (2063KB)(224) Cited By (33)
Abstract:

Objective To investigate glucose metabolism and insulin secretion in patients with chronic hepatitis B( CHB) of different Child-Pugh grades and liver cirrhosis and their association with inflammatory response. Methods A total of 147 patients with CHB and liver cirrhosis who were admitted to Guangzho...

A clinical analysis of hypoglycemia in patients with liver cirrhosis and diabetes mellitus
Zhao Juan, Hui Wei, Dou AiHua, Wei LinLin, Liu Mei, Dong GuiFang, Xu Bin
2020, 36(2): 329-332. DOI: 10.3969/j.issn.1001-5256.2020.02.019
Abstract(1405) PDF (1961KB)(214) Cited By (12)
Abstract:

Objective To investigate the causes of hypoglycemia and the features of clinical indices in patients with liver cirrhosis and diabetes mellitus. Methods A total of 50 patients with liver cirrhosis and diabetes mellitus who were admitted to Beijing YouAn Hospital,Capital Medical University,from Janua...

Characteristics of intestinal flora before and after transjugular intrahepatic portosystemic shunt in patients with liver cirrhosis
Li Qiang, Zhu QingLiang, Zhang HaiLong, Deng MingMing, Hu Qing, Wang ZiJie
2020, 36(2): 333-337. DOI: 10.3969/j.issn.1001-5256.2020.02.020
Abstract(1183) PDF (2816KB)(254) Cited By (9)
Abstract:

Objective To investigate the characteristics of flora microbiota before and after transjugular intrahepatic portosystemic shunt( TIPS) in patients with liver cirrhosis. Methods A total of 18 patients with liver cirrhosis who were hospitalized and underwent TIPS in Department of Gastroenterology,The ...

Prognostic and risk factors for patients undergoing recanalization due to shunt dysfunction after transjugular intrahepatic portosystemic shunt
Zhang XiaoFeng, Zhang Wei, Yu ZhiYuan, Zhu GeYuZheng
2020, 36(2): 338-342. DOI: 10.3969/j.issn.1001-5256.2020.02.021
Abstract(1148) PDF (2023KB)(193) Cited By (4)
Abstract:

Objective To investigate the prognostic and risk factors for cirrhotic patients undergoing recanalization due to shunt dysfunction after transjugular intrahepatic portosystemic shunt( TIPS). Methods A retrospective analysis was performed for the clinical data of 69 cirrhotic patients who were admitt...

Risk factors for hepatic encephalopathy after emergency transjugular intrahepatic portosystemic shunt for patients with acute esophagogastric variceal bleeding
Yao YunHai, Luo Yan, Zhu JingLe, Gan JianHe, Zhao WeiFeng
2020, 36(2): 343-347. DOI: 10.3969/j.issn.1001-5256.2020.02.022
Abstract(1121) PDF (1966KB)(211) Cited By (19)
Abstract:

Objective To investigate the risk factors for hepatic encephalopathy( HE) after emergency transjugular intrahepatic portosystemic shunt( TIPS) for patients with acute esophagogastric variceal bleeding( EVB) based on an analysis of clinical outcomes. Methods A retrospective analysis was performed for...

Original articles_Liver neoplasms
Influence of ideal cardiovascular health behaviors and factors on the onset of primary liver cancer
Cui HaoZhe, Zhao Li, Sun MiaoMiao, Kang JianZhong, Wang WanChao, Liu SiQing, Cao LiYing
2020, 36(2): 348-353. DOI: 10.3969/j.issn.1001-5256.2020.02.023
Abstract:

Objective To investigate the influence of ideal cardiovascular health behaviors and factors on the onset of primary liver cancer in northern China. Methods A prospective cohort study was conducted for 95 055 on-the-job or retired employees of Kailuan Group who underwent physical examination from Jul...

Expression of CD90 in intrahepatic cholangiocellular carcinoma and its association with poor prognosis
Zhu Tong, Rao JingFen, Liu ChengYi, Zhao Shuang, Zhang Li
2020, 36(2): 354-357. DOI: 10.3969/j.issn.1001-5256.2020.02.024
Abstract(1021) PDF (2269KB)(169) Cited By (2)
Abstract:

Objective To investigate the expression of CD90 in human intrahepatic cholangiocellular carcinoma and its association with lymph node metastasis and poor prognosis. Methods A total of 49 samples of intrahepatic cholangiocellular carcinoma tissue and 49 samples of adjacent tissue were collected after...

Short-and long-term effects of radiofrequency ablation versus minimally invasive hepatectomy in treatment of small hepatocellular carcinoma: A Meta-analysis
Tang JinQuan, He Pan, Su Song, Luo Bin, Fang Cheng, Li Bo, Xia XianMing, Li YuWei
2020, 36(2): 358-362. DOI: 10.3969/j.issn.1001-5256.2020.02.025
Abstract(1310) PDF (2366KB)(205) Cited By (4)
Abstract:

Objective To investigate the short-and long-term effects of radiofrequency ablation( RA) versus minimally invasive hepatectomy( MIH) in the treatment of small hepatocellular carcinoma( SHCC). Methods PubMed,Web of Science,Embase,Cochrane Library,CBM,CNKI,Wanfang Data,and VIP were searched for Chines...

Efficacy and safety of Kanglaite injection combined with transarterial chemoembolization in treatment of advanced liver cancer: A Meta-analysis
Sun DongXue, Yang Zhu, Long FengXi, Wei XianMan, Tang DongXin
2020, 36(2): 363-368. DOI: 10.3969/j.issn.1001-5256.2020.02.026
Abstract(1433) PDF (2638KB)(211) Cited By (13)
Abstract:

Objective To investigate the efficacy and safety of Kanglaite injection( KLT) combined with transarterial chemoembolization( TACE) in the treatment of advanced liver cancer through a Meta-analysis. Methods CNKI,Wanfang Data,VIP,CBM,PubMed,Cochrane Library,and Embase were searched for clinical studie...

Validation of applicability of reference intervals for serum alpha-fetoprotein and carcinoembryonic antigen for adults in Changchun,China
Zhu XueTong, Wang KaiJin, Zhou Qi, Xu JianCheng
2020, 36(2): 369-371. DOI: 10.3969/j.issn.1001-5256.2020.02.027
Abstract(1141) PDF (2183KB)(197) Cited By (4)
Abstract:

Objective To investigate whether the reference intervals for serum alpha-fetoprotein( AFP) and carcinoembryonic antigen( CEA) in WS/T 645. 2-2018 are applicable to the adults in Changchun,China. Methods According to the validation method for the reference intervals in WS/T 645. 2-2018,5420 subjects,...

Expression of proteasome subunit beta type 4 in hepatocellular carcinoma and its association with prognosis
Lu Qian, Zhu Li, Cheng Xin, Huang Hua, Chen Zhong
2020, 36(2): 372-376. DOI: 10.3969/j.issn.1001-5256.2020.02.028
Abstract:

Objective To investigate the expression of proteasome subunit beta type 4( PSMB4) in hepatocellular carcinoma( HCC) tissue and normal liver tissue and its significance in clinical prognosis. Methods Eight fresh HCC tissue specimens were collected from the patients who underwent surgical treatment in...

Construction of the eukaryotic expression vector of collagen triple helix repeat containing 1 gene and its association with microRNA-30b
Zhou HuiFang, Wei HeRu, Ma ShiChao, Zhang ChaoQun, Wang JunPing, Yang XinYing, Xie Ying, Sun DianXing
2020, 36(2): 377-380. DOI: 10.3969/j.issn.1001-5256.2020.02.029
Abstract:

Objective To construct pCTHRC1-IRES2-EGFP eukaryotic expression vector,and to investigate the association between collagen triple helix repeat containing 1( CTHRC1) gene and miR-30 b. Methods Specific primers were designed and PCR was used for the amplification and synthesis of the sequence of CTHRC...

Effect of NOR1 gene knockout on nude mice xenograft tumor of human liver cancer and its mechanism of action
You Kun, Wang DaJun, Wang Liang, Wang JianGuo
2020, 36(2): 381-386. DOI: 10.3969/j.issn.1001-5256.2020.02.030
Abstract(1126) PDF (3090KB)(202) Cited By (3)
Abstract:

Objective To investigate the effect of NOR1 gene knockout on the growth of nude mice xenograft tumor of human liver cancer,the survival rate of nude mice,and organ damage in nude mice. Methods A total of 30 specific pathogen-free male BALB/C nude mice were randomly divided into control group,Scrambl...

Original articles_Other liver diseases
Composition and changing trend of the etiologies of liver failure in Shaanxi Province,China
Yan TaoTao, Li Juan, Fu Shan, Zhang Rou, Ren DanFeng, Zhu Li, Liu JinFeng, He YingLi, Zhao YingRen, Zhang XinXin
2020, 36(2): 387-390. DOI: 10.3969/j.issn.1001-5256.2020.02.031
Abstract(988) PDF (2354KB)(173) Cited By (10)
Abstract:

Objective To investigate the composition and changing trend of the etiologies of liver failure in Shaanxi Province,China.Methods A retrospective analysis was performed for the clinical data of 975 patients with liver failure who were hospitalized in The First Affiliated Hospital of Xi'an Jiaotong Un...

Expression and significance of the long non-coding RNA EXOC7 in nonalcoholic fatty liver disease
Zhang LiYun, Deng JiaQi, Zhang Shuang, Deng HuaJiang, Li XiaoHong
2020, 36(2): 391-394. DOI: 10.3969/j.issn.1001-5256.2020.02.032
Abstract(1124) PDF (2200KB)(192) Cited By (5)
Abstract:

Objective To investigate the expression of the long non-coding RNA( lncRNA) EXOC7 in serum and liver biopsy tissue of patients with nonalcoholic fatty liver( NAFLD) and its clinical significance. Methods A total of 120 patients who underwent liver biopsy in The Affiliated Hospital of Southwest Medic...

Original articles_Pancreatic diseases
A comparative analysis of acute pancreatitis and hyperamylasemia after endoscopic retrograde cholangiopancreatography
Ma Min, Zhou ZhongYin
2020, 36(2): 395-398. DOI: 10.3969/j.issn.1001-5256.2020.02.033
Abstract(1250) PDF (1970KB)(177) Cited By (15)
Abstract:

Objective To investigate the clinical features of patients with acute pancreatitis versus hyperamylasemia after endoscopic retrograde cholangiopancreatography( ERCP) and related influencing factors,and to provide a basis for preventing disease progression. Methods A retrospective analysis was perfor...

Clinical features of patients with pancreatic neuroendocrine tumor and influencing factors for prognosis
Chen FeiFan, Chen CongYing, Zhang YaJing, Zhang YiYi, Huang YinShi, Xu Min
2020, 36(2): 399-403. DOI: 10.3969/j.issn.1001-5256.2020.02.034
Abstract(1217) PDF (1972KB)(187) Cited By (2)
Abstract:

Objective To investigate the clinical features of patients with pancreatic neuroendocrine tumor( PNET) and the influencing factors for prognosis. Methods A retrospective analysis was performed for the clinical data of 54 patients with pathologically confirmed PNET in The First Affiliated People's Ho...

Experience of individualized radiofrequency ablation in patients aged 65 years or older with liver tumors
Jiang Hua, Wang YueHua, Liu JiaFeng, Liu DongBin, Zheng YaMin
2020, 36(2): 404-405. DOI: 10.3969/j.issn.1001-5256.2020.02.035
Abstract:
Case reports
Sarcomatoid hepatocellular carcinoma with leukemoid reaction: A case report
Chu YuShan, Zhu XiaoQing, Zhang YuYu, Zhao Hui
2020, 36(2): 406-408. DOI: 10.3969/j.issn.1001-5256.2020.02.036
Abstract:
Brucellosis with fever,liver injury,and severe thrombopenia as manifestations: A case report
Xia BinFeng, Cai YanJun, Du ZhongHua, Qi Yue, Li WanYu
2020, 36(2): 409-411. DOI: 10.3969/j.issn.1001-5256.2020.02.037
Abstract:
A case of hemophagocytic syndrome with liver failure as the main manifestation
Luo LiTing, Zhang Xia, Ma HeMing, Ren TianQi, Cao He, Niu JunQi
2020, 36(2): 412-413. DOI: 10.3969/j.issn.1001-5256.2020.02.038
Abstract(1022) PDF (1975KB)(186) Cited By (3)
Abstract:
Reviews
Research advances in fecal microbiota transplantation for the treatment of HBeAg-positive chronic hepatitis B
Yang YuPing, Zhuang KangMin, Li JinYing, Huang Wei
2020, 36(2): 414-416. DOI: 10.3969/j.issn.1001-5256.2020.02.039
Abstract:

HBeAg seroconversion is an important process during antiviral therapy for patients with HBeAg-positive chronic hepatitis B( CHB),while the first-line antiviral drugs,such as entecavir and tenofovir disoproxil fumarate,tend to have low HBeAg clearance rate and/or seroconversion rate,and at present,th...

Surgical treatment of cirrhotic portal hypertension: Current status and research advances
Zhang ChunYu, Liu ZuoJin
2020, 36(2): 417-420. DOI: 10.3969/j.issn.1001-5256.2020.02.040
Abstract(1265) PDF (1950KB)(310) Cited By (16)
Abstract:

Liver cirrhosis can lead to continuous pathological elevation of portal venous pressure,resulting in various complications such as esophageal and gastric varices,ascites,hepatic encephalopathy,and secondary circulatory dysfunction. Multimodality therapy is the main treatment method for portal hypert...

The trend and value of18F-FDG PET/CT included in the criteria for liver transplantation in hepatocellular carcinoma
Pu ChaoYu, Wang JianJie, Zhou Li, Chen Hong
2020, 36(2): 421-425. DOI: 10.3969/j.issn.1001-5256.2020.02.041
Abstract:

Liver transplantation is an effective method for the treatment of hepatocellular carcinoma( HCC). In order to reduce the high recurrence rate of tumor after liver transplantation for HCC,some scholars put forward the famous Milan criteria. Since the Milan criteria are too strict,some HCC patients wi...

Role of oxidative stress and autophagy in the development and progression of hepatocellular carcinoma
Wang YuLu, Xu XiaoYang, Yu XiaoHan, Ping Jian, Zhao ChangQing
2020, 36(2): 426-429. DOI: 10.3969/j.issn.1001-5256.2020.02.042
Abstract(966) PDF (2051KB)(199) Cited By (16)
Abstract:

Hepatocellular carcinoma( HCC) is a primary malignant tumor of the liver and has a complex pathogenesis. At present,the oxidative stress theory is one of the many important theories for the mechanism of the development and progression of this disease. Autophagy is an important way for cells to clear...

Research advances in circulating free DNA in liver cancer and liver-related parasitic diseases
Hou YaJun, Zhang LingQiang, Fan HaiNing
2020, 36(2): 430-432. DOI: 10.3969/j.issn.1001-5256.2020.02.043
Abstract:

Liquid biopsy is a new noninvasive detection method and is also the main molecular detection method to guide the application of precision medicine. Liquid biopsy mainly includes the measurement of circulating free DNA( cf-DNA),circulating tumor cells,and exosomes,and in particular,cf-DNA is becoming...

Risk factors for the development and progression of nonalcoholic fatty liver disease
Yao ChengZi, Feng Gong, Yu WenSi, Du Huan, Mi Man
2020, 36(2): 433-436. DOI: 10.3969/j.issn.1001-5256.2020.02.044
Abstract(1071) PDF (1962KB)(255) Cited By (35)
Abstract:

The prevalence rate of nonalcoholic fatty liver disease( NAFLD) is increasing year by year,and at present,it has become one of the most common chronic liver diseases in adults in China. NAFLD can progress from nonalcoholic fatty degeneration of the liver to nonalcoholic steatohepatitis,liver cirrhos...

Effect of different diet and exercise strategies on patients with nonalcoholic fatty liver disease
Wang Tao, Jiang YuanYe, Wang XueWei, Cao Qin, Ji Guang
2020, 36(2): 437-441. DOI: 10.3969/j.issn.1001-5256.2020.02.045
Abstract(858) PDF (1976KB)(210) Cited By (13)
Abstract:

The incidence rate of nonalcoholic fatty liver disease( NAFLD) keeps increasing year by year,making NAFLD one of the most common liver diseases in the world. Reasonable diet and exercise are currently recognized as the most crucial step in the treatment of NAFLD and are the cornerstone of the manage...

Current status of research on fibrates in treatment of primary biliary cholangitis
Wei Jing, Wu XiRun
2020, 36(2): 442-445. DOI: 10.3969/j.issn.1001-5256.2020.02.046
Abstract(982) PDF (1969KB)(256) Cited By (11)
Abstract:

At present,ursodeoxycholic acid( UDCA) and obeticholic acid( OCA) are approved by FDA for the treatment of primary biliary cholangitis( PBC). New drugs are urgently needed for the patients who have inadequate response to UDCA or cannot tolerate pruritus,a common side effect of OCA. In recent years,a...

Research advances in cytokines associated with primary biliary cholangitis
Huang ZhiQin, Huang HuiFang
2020, 36(2): 446-450. DOI: 10.3969/j.issn.1001-5256.2020.02.047
Abstract:

Primary biliary cholangitis( PBC) is an autoimmune liver disease characterized by nonsuppurative inflammation of the small-and medium-sized bile ducts in the liver. The pathogenesis of PBC remains unclear,and immunoregulation may play a critical role. As the important components of the immune system...

Programmed necrosis of macrophages plays an important role in liver immune response
Zhou SiMin, Guo LiPing, Zhang Jun, Zhou Lu, Wang BangMao
2020, 36(2): 451-455. DOI: 10.3969/j.issn.1001-5256.2020.02.048
Abstract:

Liver macrophages are in a dynamic equilibrium of immune tolerance and immune response after continuous antigen stimulation.The immune response of liver macrophages to external antigen is closely associated with the immune homeostasis of the liver. This article reviews the association between the pr...

Role of silent information regulator 4 in the development and progression of liver diseases
Xie Li, Zhang NingPing, Wu Jian
2020, 36(2): 456-459. DOI: 10.3969/j.issn.1001-5256.2020.02.049
Abstract(1080) PDF (1976KB)(269) Cited By (1)
Abstract:

Silent information regulators are a family of highly conserved nicotinamide adenine dinucleotide( NAD+)-dependent deacetylases and has seven members( Sirt1-7). Silent information regulator 4( Sirt4),localized in the mitochondria,possesses the activity of deacetylase,ADP-ribosyltransferase,NAD+-depen...

The immunoregulatory effect of tumor necrosis factor-alpha-induced protein 8-like 2 in different liver diseases
Wang ShanShan, Zhang QingShan, Zhao SuXian, Kong LingBo, Ji Lei, Kong Li
2020, 36(2): 460-463. DOI: 10.3969/j.issn.1001-5256.2020.02.050
Abstract:

Tumor necrosis factor-alpha-induced protein 8-like 2( TIPE2) can negatively regulate innate immunity and adaptive immunity and participate in the development and progression of various liver diseases,such as hepatitis,liver cirrhosis,and hepatocellular carcinoma,by affecting a variety of signaling p...

Endoplasmic reticulum stress signaling pathway and its association with liver diseases
Li Yao, Wang ZhiXin, Wen Hao, Wang HaiJiu, Cai RangDongZhi, Yu WenHao, Zhang Li, Fan HaiNing
2020, 36(2): 464-467. DOI: 10.3969/j.issn.1001-5256.2020.02.051
Abstract(1505) PDF (1967KB)(215) Cited By (15)
Abstract:

Endoplasmic reticulum stress( ERS) manifests as the aggregation of misfolded and unfolded proteins in the endoplasmic reticulum lumen and disorder of calcium balance and can activate the signaling pathways involved in unfolded protein response,endoplasmic reticulum overload reaction,and sterol regul...

Research advances in the impairment of Oddi sphincter function caused by endoscopic sphincterotomy
Wang JunMin, Ren WeiRui, Meng Xia, Zhao LiWei, Jiang Tao
2020, 36(2): 468-471. DOI: 10.3969/j.issn.1001-5256.2020.02.052
Abstract(1399) PDF (1965KB)(188) Cited By (10)
Abstract:

The Oddi sphincter has a delicate structure,and the integrity of its function has an irreplaceable role in preventing retrograde infection due to the reflux of duodenal contents and bacteria and maintaining the balance of physiological environment inside and outside the liver,the pancreas,and the ga...

Value of clinical staging and typing of hilar cholangiocarcinoma in evaluating radical resection and prognosis
Xin Qi, Yu XiaoYuan, Liu XingKai, Zhang Ping
2020, 36(2): 472-475. DOI: 10.3969/j.issn.1001-5256.2020.02.053
Abstract(1423) PDF (1962KB)(246) Cited By (11)
Abstract:

Hilar cholangiocarcinoma( HCCA) is a malignant tumor arising from the epithelium of the bile duct,which involves the common hepatic duct,the left and right hepatic ducts,and the confluence areas of these bile ducts. HCCA has an insidious onset and most patients are in the advanced stage when jaundic...

Research advances in intraductal papillary neoplasm of the bile duct
Wang ShiDong, Wang XiaoWei, Liu GuoHong, Tian ZiBin, Zhao QingXi
2020, 36(2): 476-480. DOI: 10.3969/j.issn.1001-5256.2020.02.054
Abstract(1347) PDF (1973KB)(267) Cited By (9)
Abstract:

Intraductal papillary neoplasm of the bile duct( IPNB) is a rare type of bile duct tumors with different classification criteria and has a better prognosis than cholangiocarcinoma. Clinicians lack the awareness of this disease due to its low incidence rate. This article reviews recent research advan...