With the successful application of direct-acting antivirals (DAAs) in the treatment of hepatitis C, clinical management of drug-drug interaction (DDI) has become a hot topic in this field.Most DAAs develop DDI with other drugs administered at the same time via cytochrome P450 or transporters in the ...

Chronic hepatitis C (CHC) is a chronic and progressive disease prevalent in the whole world and greatly threatens human health.The launch of direct-acting antiviral agents (DAAs) brings a revolutionary change in the treatment of CHC.In recent years, several DAAs have been marketed in foreign countri...

Dual infection with hepatitis C virus (HCV) and hepatitis B virus (HBV) has significantly different clinical, immunological, and virological features from single infection with HCV or HBV, which brings various challenges to clinical diagnosis/treatment and management.Direct-acting antiviral agents u...

Chronic Hepatitis C is a global epidemic, and people with different sexes, ages, races, and nationalities are susceptible to hepatitis C virus (HCV) infection.This article elaborates on the management method and individualized treatment regimens for special populations, including children with hepat...

Chronic hepatitis C in children has an insidious onset and has few available treatment options.Pegylated interferon alpha (Peg-IFNα) combined with ribavirin (RBV) , known as the PR regimen for short, used to be the standard regimen; however, treatment response is often affected by various factors in...

The incidence of hepatitis C virus infection is commonly seen in patients with renal dysfunction (RD) , especially those with end-stage renal disease on hemodialysis (HD) , among whom the incidence and mortality of liver diseases increase.The development of direct-acting antiviral agents has revolut...

Objective To investigate the efficacy and safety of interferon-α (IFN-α) given additionally or sequentially after effective inhibition of HBV DNA by long-term entecavir (ETV) therapy versus ETV alone in the treatment of chronic hepatitis B (CHB) .Methods A total of 27 CHB patients with negative HBV ...

Objective To investigate the antiviral effect of tenofovir disoproxil fumarate (TDF) versus entecavir (ETV) in the treatment of treatment-nave patients with chronic HBV infection.Methods A total of 420 treatment-nave patients with chronic HBV infection or liver cirrhosis who received antiviral the...

Objective To investigate the correlation of the expression of Toll-like receptor 2 (TLR2) and Toll-like receptor 3 (TLR3) in live tissue with the grade of liver inflammation and degree of liver fibrosis and related clinical significance in patients with chronic hepatitis B (CHB) .Methods A total of ...

Objective To investigate the detection rate and features of autoantibodies in chronic hepatitis C (CHC) patients after plasmaphoresis, as well as the liver pathological features of autoantibody-positive CHC patients.Methods A total of 120 patients who were infected with hepatitis C virus after plasm...

Objective To investigate the influence of the Notch signaling pathway on CD8+T lymphocyte function in patients with chronic hepatitis C (CHC) and the role of the Notch signaling pathway in the pathogenesis of CHC.Methods A total of 38 treatment-na6 ve CHC patients who visited Shaanxi Provincial Peop...

Objective To investigate the value of albumin-bilirubin (ALBI) score combined with aspartate aminotransferase-to-platelet ratio index (APRI) in predicting the development of posthepatectomy liver failure (PHLF) in patients with HBV-related hepatocellular carcinoma (HCC) .Methods A retrospective anal...

Objective To investigate the expression of interleukin-17 (IL-17) in hepatitis B virus (HBV) -related hepatocellular carcinoma (HCC) with different levels of alpha-fetoprotein (AFP) , as well as its association with recurrence and prognosis after radical treatment for HCC.Methods A total of 167 pati...

Objective To investigate the effect of enhanced recovery after surgery (ERAS) versus traditional rehabilitation program in patients undergoing hepatectomy.Methods Pub Med, EBSCO, MEDLINE, and Cochrane Library were searched for the articles on the effect of ERAS versus traditional rehabilitation prog...

Objective To investigate the expression of the long non-coding RNA (lncRNA) XLOC-007123 in cancer and adjacent tissue, as well as hepatoma cell lines, in patients with hepatitis B-related hepatocellular carcinoma (HCC) , and the association between its expression level and clinicopathological featur...

Objective To investigate the inhibitory effect of fibroblast growth factor-21 (FGF-21) on the carcinogenesis of L02 cells induced by diethylnitrosamine (DEN) .Methods L02 cells were cultured and treated with different concentrations of DEN (1, 10, 20, 50, 100, and 150 μmol/L) .MTT assay was used to ...

Objective To investigate the value of serum and biliary carcinoembryonic antigen (CEA) , carbohydrate antigen 19-9 (CA19-9) , and carbohydrate antigen 24-2 (CA24-2) in the diagnosis of benign and malignant biliary obstructive diseases.Methods A total of 40 patients with benign biliary obstructive di...

Objective To investigate the effect of laparoscopic cholecystectomy on intraoperative and postoperative recovery and changes in serum levels of lipopolysaccharide (LPS) , amylase (AMY) , and adrenocorticotropic hormone (ACTH) after surgery in patients with acute cholecystitis (AC) .Methods A total o...

Objective To investigate the clinical effect and safety of biliary metal stent implantation via endoscopic retrograde cholangiopancreatography (ERCP) in the treatment of malignant extrahepatic biliary obstruction.Methods A total of 40 patients with unresectable malignant extrahepatic biliary obstruc...

Objective To investigate the clinical effect and safety of minor endoscopic sphincterotomy (m EST) combined with endoscopic papillary large balloon dilation (EPLBD) in the treatment of elderly patients with multiple large common bile duct stones.Methods A retrospective analysis was performed for 229...

Objective To investigate the predictive value of early measurement of serum inflammatory mediators for infectious pancreatic necrosis secondary to severe acute pancreatitis (SAP) .Methods A retrospective analysis was performed for the clinical data of 166 patients who were admitted to our hospital f...

Objective To investigate the effect of interference of Sema4D expression on cell biological behavior in pancreatic cancer.Methods Sema4D-siRNA was designed, synthesized, and transfected into a human pancreatic cancer cell line.The cells were divided into siRNA transfection group, negative control gr...

Objective To investigate the clinical features of drug-induced liver injury (DILI) by descriptive analysis.Methods A retrospective analysis was performed for the clinical data of 445 patients who were diagnosed with DILI in Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese M...

Objective To investigate the role of chlorogenic acid (CG) in nonalcoholic fatty liver disease (NAFLD) and possible molecular basis, since NAFLD is closely associated with insulin resistance and CG can regulate glucose and lipid metabolism and improve insulin resistance.Methods A total of 30 Sprague...

Objective To evaluate the clinical features of patients with acute/subacute liver failure (ALF/SALF) complicated by acute kidney failure (AKI) .Methods A retrospective analysis was performed for the clinical data of 115 ALF/SALF patients who were admitted to302 Hospital of PLA from January 2015 to D...

Objective To investigate the effect of ulinastatin (UTI) preconditioning combined with ischemic preconditioning (IPC) on hepatic ischemia-reperfusion (IR) injury in rats and possible mechanism of action.Methods A total of 50 male Sprague-Dawley rats were randomly divided into sham-operation group, I...

Objective To analyze whether Microtus fuscus in Qinghai-Tibet Plateau can be used as an animal model for Echinococcus infection.Methods Sixty wild voles (Microtus fuscus) were equally divided into groups A, B, and C to undergo Echinococcus inoculation through subcutaneous injection, direct transhepa...

Hepatitis C virus (HCV) infection is a global public health issue.At present, pegylated interferon (IFN) combined with ribavirin is the major therapeutic regimen for anti-HCV treatment in China, but this regimen cannot achieve ideal sustained virologic response.Direct-acting antivirals (DAA) have ac...

Chronic infection and inflammation are associated with the development of atherosclerosis, and hepatitis C virus (HCV) infection is a relatively common infectious disease.This article reviews the latest advances in the association between HCV infection and atherosclerotic diseases.Studies have shown...

Chronic hepatitis caused by hepatitis C virus (HCV) infection is one of the leading causes of liver cirrhosis and hepatocellular carcinoma.In recent years, direct-acting antiviral agents (DAAs) have gradually become main drugs for the treatment of hepatitis C.Studies have shown that DAAs may increas...

Primary liver cancer ranks fourth among the common malignant tumors in China and is the third leading cause of death.At present, only 20% patients with liver cancer are eligible for radical resection.Many clinical studies have confirmed that transcatheter arterial chemoembolization (TACE) has a good...

Primary liver cancer is a common malignant tumor in clinical practice, and secreted protein acidic and rich in cysteine (SPARC) plays a very important role in the progression and metastasis of liver cancer.This article introduces the structure and biological function of SPARC and analyzes its mechan...

More and more clinical trials have proved the efficacy of targeted drugs in the treatment of hepatocellular carcinoma (HCC) .With the development of science and technology, more and more targeted drugs have appeared.In recent years, targeted drugs such as regorafenib and ramucirumab have shown great...

The development and progression of hepatocellular carcinoma (HCC) is associated with estrogen, which exerts its physiological effect by binding to estrogen receptor (ER) .The function of ER is regulated by related genes, while the expression and function of these genes are affected by gene polymorph...

The incidence rate of nonalcoholic fatty liver disease (NAFLD) has been increasing year by year in China, and NAFLD has become one of the common chronic diseases that affect the health of Chinese residents.This article introduces the role of lifestyle intervention, reviews the types of drugs used in...

Acute liver failure (ALF) is a rare life-threatening disease with rapid progression and a low survival rate and affects the function of multiple organ systems.Early identification of cause and protection of vital organs are critical for patients' survival.With the development in artificial liver, st...

Helicobacter pylori (HP) has been listed as the first carcinogen for gastric cancer by WHO.Recent studies have shown that HP infection is associated with a variety of tumors in other parts.This article introduces the current research on HP infection and intrahepatic/extrahepatic bile duct neoplasms ...