2018 No. 12

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Editorial

Heterogeneity and homogeneity of nonalcoholic fatty liver disease

Li XiaoHe, Wei Lai

2018, 34(12): 2491-2494. DOI: 10.3969/j.issn.1001-5256.2018.12.001

Abstract(1508)

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Abstract:
Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease in China and the world. However, heterogeneity exists in the pathogenesis, pathology, and clinical phenotype of NAFLD. Metabolism/obesity and gene polymorphisms are involved in the pathogenesis of NAFLD. As for path...

Discussions by experts

Clinical trials tracking nonalcoholic fatty liver disease: Drug classification

Jia Han, Rao HuiYing

2018, 34(12): 2495-2500. DOI: 10.3969/j.issn.1001-5256.2018.12.002

Abstract(1791)

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Abstract:
At present, there are still no effective drugs launched for the treatment of nonalcoholic fatty liver disease (NAFLD) , and many drugs are being evaluated in clinical trials. These drugs have different mechanisms of action in treatment, such as improvement of glycolipid metabolism, anti-inflammation...

Clinical trials tracking nonalcoholic fatty liver disease: Noninvasive measures

Ju HuanJia, Shi JunPing

2018, 34(12): 2501-2504. DOI: 10.3969/j.issn.1001-5256.2018.12.003

Abstract(1664)

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Abstract:
Nonalcoholic fatty liver disease (NAFLD) has become one of the research hotspots in the field of liver disease. However, so far, no drugs have been approved by the U. S. Food and Drug Administration for the treatment of nonalcoholic steatohepatitis, which brings opportunities and challenges to the c...

A clinical trial on the follow-up of nonalcoholic fatty liver disease: An evaluation of pathological endpoint

Jiang LiNa, Zhao JingMin

2018, 34(12): 2505-2508. DOI: 10.3969/j.issn.1001-5256.2018.12.004

Abstract(2201)

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Abstract:
Liver biopsy is the“gold standard”for the diagnosis of nonalcoholic fatty liver disease (NAFLD) /nonalcoholic steatohepatitis (NASH) . Although liver biopsy has several limitations including invasiveness and errors in sampling and evaluation, in clinical trials on NAFLD/NASH follow-up and new drugs,...

Important issues in protocol design of exploratory and confirmatory clinical trials of new drugs for nonalcoholic steatohepatitis

Mao YiMin

2018, 34(12): 2509-2514. DOI: 10.3969/j.issn.1001-5256.2018.12.005

Abstract(1836)

PDF (1626KB)(382) Cited By (2)

Abstract:
The research and development of new drugs for nonalcoholic steatohepatitis (NASH) is a research hotspot in the field of liver diseases. Confirmatory clinical trials are the key clinical trials for new drug registration, while exploratory clinical trials usually provide a basis for confirmatory clini...

Epidemiology characteristics of nonalcoholic fatty liver disease in Asia

Li Jie

2018, 34(12): 2515-2519. DOI: 10.3969/j.issn.1001-5256.2018.12.006

Abstract(1831)

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Abstract:
The prevalence rate of nonalcoholic fatty liver disease (NAFLD) is constantly increasing due to the increase in the degree of industrialization in Asian countries and the change in lifestyle and dietary structure. Asia has a large population with uneven distribution and marked regional disparities i...

Guidelines

The clinical guidelines of diagnosis and treatment of chronic hepatitis B with traditional Chinese medicine(2018)

Hepatobiliary Specialized Committee of China Association of Chinese Medicine, Liver Diseases Specialized Committee of China Medical Associa- tion of Minorities

2018, 34(12): 2520-2525. DOI: 10.3969/j.issn.1001-5256.2018.12.007

Abstract(838)

PDF (259KB)(1233) Cited By (165)

Abstract:

Consensus on clinical application of hepatic venous pressure gradient in China (2018)

Chinese Portal Hypertension Diagnosis and Monitoring Study Group (CHESS), Minimally Invasive Intervention Collaborative Group, Chinese Society of Gastroenterology, Emergency Intervention Committee, Chinese College of Interventionalists, et al,

2018, 34(12): 2526-2536. DOI: 10.3969/j.issn.1001-5256.2018.12.008

Abstract(542)

PDF (573KB)(310) Cited By (54)

Abstract:

Chinese Guidelines for ERCP(2018)

ERCP group, Chinese Society of Digestive Endoscopology, Biliopancreatic group, Chinese Association of Gastroenterologist and Hepatologist, Na- tional Clinical Ｒesearch Center for Digestive Diseases

2018, 34(12): 2537-2554. DOI: 10.3969/j.issn.1001-5256.2018.12.009

Abstract(951)

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Abstract:

Expert consensus on perioperative medication for endoscopic retrograde cholangiopancreatography

Chinese Digestive Endoscopist Committee, Chinese Endoscopist Association, Chinese Physicians′Association, Pancreatic Disease Committee, Chinese Physicians′Association

2018, 34(12): 2555-2562. DOI: 10.3969/j.issn.1001-5256.2018.12.010

Abstract(1971)

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Abstract:

An excerpt of update on prevention, diagnosis, and treatment and of chronic hepatitis B: AASLD 2018 hepatitis B guidance

Zhang JingQiao, Li MiaoMiao, Qi XingShun, Ceng QingLei, Jia JiDong

2018, 34(12): 2563-2567. DOI: 10.3969/j.issn.1001-5256.2018.12.011

Abstract(515)

PDF (220KB)(549) Cited By (14)

Abstract:

Original articles_Viral hepatitis

Clinical features of immune escape phase and immune control phase of chronic HBV infection

Bai XiaoXiao, Dong Bing, Gao HongYan, Xu GuangHua

2018, 34(12): 2568-2571. DOI: 10.3969/j.issn.1001-5256.2018.12.012

Abstract(1557)

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Abstract:
Objective To investigate the clinical features of immune control phase and immune escape phase of chronic hepatitis B virus (HBV) infection. Methods A total of 226 patients with chronic HBV infection (with positive HBsAg, anti-HBe, and anti-HBc) who visited or were hospitalized in Yan'an University ...

Original articles_Liver fibrosis and liver cirrhosis

Influence of metabolic syndrome on significant hepatic fibrosis in patients with chronic hepatitis B

Wu QiQi, Ma Yan, Wang XiaoBo, Xu Qiang, Wang Yan, Bai Li

2018, 34(12): 2572-2577. DOI: 10.3969/j.issn.1001-5256.2018.12.013

Abstract(1728)

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Abstract:
Objective To investigate the influence of metabolic syndrome components on significant hepatic fibrosis in patients with chronic hepatitis B (CHB) and related risk factors. Methods The patients with CHB who attended Department of Hepatology in The Fourth Affiliated Hospital of Xinjiang Medical Unive...

Value of hepatic artery resistance index in evaluating progressive liver fibrosis in nonalcoholic fatty liver disease

Wang Cheng, Chen HouBin, Ma Long, Tian ZeBin, Zheng Zhi, Zhou MingXiong

2018, 34(12): 2578-2581. DOI: 10.3969/j.issn.1001-5256.2018.12.014

Abstract(2114)

PDF (1614KB)(341) Cited By (13)

Abstract:
Objective To investigate the changes in blood flow indices in patients with nonalcoholic fatty liver disease (NAFLD) and the value of hepatic artery resistance index (HARI) in evaluating progressive liver fibrosis. Methods A total of 148 patients who were diagnosed with NAFLD in The People's Hospita...

Clinical significance of fasting C-peptide combined with fibrosis-4 index in assessing the progression of liver fibrosis in type 2 diabetic patients with nonalcoholic fatty liver disease

Ren GuiJing, Han Lin, Qin ShaoYou, Wang XinGang, Zhou ZhangYu

2018, 34(12): 2582-2586. DOI: 10.3969/j.issn.1001-5256.2018.12.015

Abstract(2104)

PDF (1657KB)(311) Cited By (14)

Abstract:
Objective To investigate the clinical significance of fasting C-peptide combined with fibrosis-4 (FIB-4) index in assessing the progression of liver fibrosis in patients with type 2 diabetes mellitus (T2 DM) and nonalcoholic fatty liver disease (NAFLD) . Methods A total of 513 patients who underwent...

Value of magnetic resonance morphological imaging in the diagnosis and differentiation of post-hepatitis B cirrhosis

Liu HaiFeng, Xu YongSheng, Zhang Yue, Zhao XiaoJu, Liu Zhao, Li JinKui, Yan RuiFeng, Xu Kai, Lei JunQiang

2018, 34(12): 2587-2591. DOI: 10.3969/j.issn.1001-5256.2018.12.016

Abstract(1829)

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Abstract:
Objective To investigate the value of magnetic resonance (MR) morphological imaging in the diagnosis and differentiation of post-hepatitis B cirrhosis. Methods A prospective study was performed for 70 patients with liver cirrhosis who were consecutively admitted to The First Hospital of Lanzhou Univ...

Value of psychometric hepatic encephalopathy score in the diagnosis of minimal hepatic encephalopathy in patients with liver cirrhosis

Wang YanYan, Zhao YuYang, Sun ShuJian, Wang GuoHua, Zhao Ping

2018, 34(12): 2592-2598. DOI: 10.3969/j.issn.1001-5256.2018.12.017

Abstract(2086)

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Abstract:
Objective To investigate the value of psychometric hepatic encephalopathy score (PHES) in the diagnosis of minimal hepatic encephalopathy (MHE) and related influencing factors, as well as the prevalence rate of MHE among patients with liver cirrhosis and related risk factors. Methods A total of 138 ...

Value of advanced dynamic flow versus color Doppler flow imaging in evaluating stent patency after transjugular intrahepatic portosystemic shunt

Guo DanDan, Tang ShaoShan

2018, 34(12): 2599-2602. DOI: 10.3969/j.issn.1001-5256.2018.12.018

Abstract(1912)

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Abstract:
Objective To investigate the value of advanced dynamic flow (ADF) versus color Doppler flow imaging (CDFI) in evaluating stent patency after transjugular intrahepatic portosystemic shunt (TIPS) . Methods A total of 60 post-TIPS patients who underwent ADF, CDFI, and contrast-enhanced ultrasound (CEUS...

Original articles_Liver neoplasms

Influence of time schedule of radiofrequency ablation on the safety and prognosis of patients with colorectal cancer liver metastasis receiving XELOX regimen: A single-center clinical study

Ding XiaoYan, Chen JingLong, Sun Wei, Li WenDong, Guo XiaoDi, Shen YanJun, Sun ShaSha, Zhuang XiuFen

2018, 34(12): 2603-2609. DOI: 10.3969/j.issn.1001-5256.2018.12.019

Abstract(1695)

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Abstract:
Objective To investigate the influence of time schedule of radiofrequency ablation (RFA) on the safety and prognosis of patients with colorectal cancer liver metastasis treated with RFA combined with XELOX regimen. Methods A retrospective analysis was performed for the clinical data of 48 patients w...

Effect of tumor-stroma crosstalk on amino acid metabolism in hepatic stellate cells

Wu Jing, Meng QingHua, Xue Ran

2018, 34(12): 2610-2613. DOI: 10.3969/j.issn.1001-5256.2018.12.020

Abstract(1700)

PDF (1704KB)(313) Cited By (2)

Abstract:
Objective To investigate the effect of tumor-stroma crosstalk on amino acid metabolism in hepatic stellate cells (HSCs) .Methods Human hepatoma cell lines HepG2, Hep3 B, and Huh7 and the HSC LX-2 were cultured separately. HSCs were cultured in HSC LX-2 conditioned medium (LX2-CM) and HepG2/Hep3 B/Hu...

Effect of cyclooxygenase-2 antisense RNA combined with celecoxib on the proliferation and apoptosis of hepatoma cells

Zhu YueKun, Zhao XianQi, Wang DaWei, Zhang Wei, Tian MaoLin, Li ZhengTian, Zhao Long, Li Chao, Jiang HongChi

2018, 34(12): 2614-2618. DOI: 10.3969/j.issn.1001-5256.2018.12.021

Abstract(1483)

PDF (1819KB)(324) Cited By (5)

Abstract:
Objective To investigate the antitumor effect of cyclooxygenase-2 (COX-2) antisense RNA combined with celecoxib on hepatoma CBRH7919 cells. Methods The effect of celecoxib on in vitro proliferative activity, cell cycle, and apoptosis of hepatoma cell lines CBRH7919, CBRH7919-E, and CBRH7919-A (trans...

Original articles_Others

Association between fatty liver disease and lacunar infarction

Huang YingTing, Dai Biao

2018, 34(12): 2619-2623. DOI: 10.3969/j.issn.1001-5256.2018.12.022

Abstract(1629)

PDF (1621KB)(366) Cited By (1)

Abstract:

Objective To investigate whether fatty liver disease is a risk factor for lacunar infarction. Methods A retrospective analysis was performed for the clinical data of 457 patients with lacunar infarction (lacunar infarction group) and 120 control patients, who were hospitalized in our hospital from 2...

Effect of probiotics in treatment of nonalcoholic fatty liver disease: A Meta-analysis

Hou Jie, Liu LiXin

2018, 34(12): 2624-2630. DOI: 10.3969/j.issn.1001-5256.2018.12.023

Abstract(1673)

PDF (2314KB)(336) Cited By (12)

Abstract:

Objective To systematically analyze the value of probiotics in the treatment of nonalcoholic fatty liver disease (NAFLD) .Methods PubMed, The Cochrane Library, Embase, Medline, CNKI, VIP, and Wanfang Data were searched for randomized controlled trials (RCTs) on probiotics in the treatment on NAFLD p...

Value of betatrophin in predicting nonalcoholic fatty liver disease

Zhang LiLi, Gao FuLai

2018, 34(12): 2631-2634. DOI: 10.3969/j.issn.1001-5256.2018.12.024

Abstract(1557)

PDF (1667KB)(303) Cited By (7)

Abstract:

Objective To investigate the value of betatrophin in predicting nonalcoholic fatty liver disease (NAFLD) . Methods A total of160 patients with NAFLD who were diagnosed and treated in our hospital from January 2017 to January 2018 were enrolled in this study and were divided into low fat content (LFC...

Preventive and therapeutic effects of Babaodan on hepatic encephalopathy in rats with acute liver failure

Lu Lu, Wu Chao, Xie Dong, An YongTong, Zhao YaHong, Ye Guan, Sun MingYu

2018, 34(12): 2635-2641. DOI: 10.3969/j.issn.1001-5256.2018.12.025

Abstract(1784)

PDF (1974KB)(331) Cited By (13)

Abstract:

Objective To investigate the preventive and therapeutic effects of Babaodan on hepatic encephalopathy in rats with acute liver failure and possible mechanisms. Methods A total of 50 Wistar rats were randomly divided into normal group, model group, low-dose Babaodan group, high-dose Babaodan group, a...

Effect of the warming and heat-clearing method on the percentage of regulatory T lymphocytes/T helper 17 cells in rats with acute-on-chronic liver failure

Chen Bin, Zhang Tao, Zhu WenFang, Peng Jie, Zhang QianQian, Li YunFang, Ding XiuLi

2018, 34(12): 2642-2647. DOI: 10.3969/j.issn.1001-5256.2018.12.026

Abstract(1835)

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Abstract:

Objective To investigate the effect of the warming and heat-clearing method on the percentage of regulatory T (Treg) /T helper 17 (Th17) cells in rats with acute-on-chronic liver failure (ACLF) and the mechanism of its anti-liver failure activity. Methods A total of 140 Sprague-Dawley rats were rand...

Case reports

‍Changes in serological markers of HBV during 4-year antiviral treatment with entecavir: A case report

Wang HaiXia, Qi Yue

2018, 34(12): 2648-2649. DOI: 10.3969/j.issn.1001-5256.2018.12.027

Abstract(1878)

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Abstract:

Daclatasvir hydrochloride combined with asunaprevir for treatment of genotype 1b chronic hepatitis C: A report of 13 cases

Feng YiNong, Wang ZeHong, Zhou Li, Shi ShaoYuan, Wang YongXiang

2018, 34(12): 2650-2652. DOI: 10.3969/j.issn.1001-5256.2018.12.028

Abstract(1640)

PDF (1605KB)(334) Cited By (2)

Abstract:

Hepatitis B cirrhosis with dermatomyositis: A case report

Li YanYan, Wen XiaoYu, Zhang Juan, Gao RunPing

2018, 34(12): 2653-2654. DOI: 10.3969/j.issn.1001-5256.2018.12.029

Abstract(1580)

PDF (1665KB)(308)

Abstract:

Early continuous venovenous hemodiafiltration combined with hemoperfusion for successful treatment of acute liver failure and hepatic encephalopathy caused by mushroom poisoning: A report of 2 cases

Hou HongXiang, Zhao Liang, Jiang XiaoMing, Liu XiaoLiang

2018, 34(12): 2655-2658. DOI: 10.3969/j.issn.1001-5256.2018.12.030

Abstract(1634)

PDF (1621KB)(306) Cited By (18)

Abstract:

IgG4-related sclerosing cholangitis: A case report

Jiang JiChang, Zhao LiJin, Tu Kui, Sun XianLong

2018, 34(12): 2659-2661. DOI: 10.3969/j.issn.1001-5256.2018.12.031

Abstract(1588)

PDF (2006KB)(326) Cited By (1)

Abstract:

Pancreatic acinar cell carcinoma with acute pancreatitis as the first symptom: A case report

Zhu ZeMin, Xie ZhiQin, Zhao ZhiJian, Li HongXia, Xu Tao, Tang CaiXi

2018, 34(12): 2662-2664. DOI: 10.3969/j.issn.1001-5256.2018.12.032

Abstract(1801)

PDF (1842KB)(326) Cited By (1)

Abstract:

Splenic arterial bleeding due to acute recurrent pancreatitis: A case report

Xin Qi, Bai ZhiQing, Zhou MingMing, Zhang Ping

2018, 34(12): 2665-2667. DOI: 10.3969/j.issn.1001-5256.2018.12.033

Abstract(1428)

PDF (1680KB)(295) Cited By (2)

Abstract:

Epidermoid cyst in the intrapancreatic accessory spleen: A case report

Yang Fan, Liu Feng, Liu YaHui, Zhang Wei, Wang ShouQian, Wang Kun, Wang YingChao

2018, 34(12): 2668-2669. DOI: 10.3969/j.issn.1001-5256.2018.12.034

Abstract(1590)

PDF (1720KB)(285) Cited By (3)

Abstract:

Spontaneous rupture of splenic angiosarcoma: 2 cases report

Wang ShuPeng, Han KaiZe, Wang Wu, Yang Yang, Liu YaHui

2018, 34(12): 2670-2671. DOI: 10.3969/j.issn.1001-5256.2018.12.035

Abstract(1520)

PDF (1874KB)(306) Cited By (2)

Abstract:

Reviews

Clinical issues in the diagnosis and treatment of tuberculosis patients with positive antibody to hepatitis C virus

Zhan ShuHua, Chen Qing, Ma ShiWu

2018, 34(12): 2672-2676. DOI: 10.3969/j.issn.1001-5256.2018.12.036

Abstract(1145)

PDF (1940KB)(329) Cited By (5)

Abstract:
Tuberculosis patients with positive antibody to hepatitis C virus (TB-HCV patients) are often seen in clinical practice, and these TB-HCV patients include those with HCV infection. That makes the clinical management and diagnosis/treatment of TB-HCV difficult. This article introduces the prevalence ...

The role of traditional Chinese medicine in regulating cytokines associated with liver fibrosis

Sheng QingShou, Lai GuoQuan, Yu XueJing, Wei Cui

2018, 34(12): 2677-2680. DOI: 10.3969/j.issn.1001-5256.2018.12.037

Abstract(1651)

PDF (1683KB)(362) Cited By (9)

Abstract:
Traditional Chinese medicine (TCM) therapy has the advantage of regulating cytokines associated with liver fibrosis and is a candidate for the treatment of liver fibrosis in the future. This article summarizes the research advances in the role of TCM in regulating cytokines associated with liver fib...

Value of magnetic resonance functional imaging in evaluating microvascular invasion of hepatocellular carcinoma

Wang LiLi, Li JunFeng, Dou Yu, Guo ShunLin, Lei JunQiang

2018, 34(12): 2681-2684. DOI: 10.3969/j.issn.1001-5256.2018.12.038

Abstract(1610)

PDF (1616KB)(335) Cited By (9)

Abstract:
Microvascular invasion, as a predictive factor for postoperative recurrence of hepatocellular carcinoma (HCC) , can only be diagnosed by the gold standard of pathological histology at present. Conventional imaging examination and serological markers have low sensitivity and specificity in evaluating...

Advances in the prevention and treatment of posthepatectomy liver failure in patients with primary liver cancer

Mai RongYun, Ye JiaZhou, Bai Tao, Ceng Jie, Chen Jie, Huang Shan, Wu FeiXiang, Li LeQun, Wu GuoBin

2018, 34(12): 2685-2692. DOI: 10.3969/j.issn.1001-5256.2018.12.039

Abstract(1969)

PDF (1675KB)(350) Cited By (25)

Abstract:
Posthepatectomy liver failure (PHLF) is a major cause of perioperative death after hepatectomy. This article summarizes the current status of research on risk factors contributing to PHLF, prediction methods, preventive measures, and related expert consensus, and it is pointed out that an objective ...

Research advances in nonalcoholic fatty liver disease-related hepatocellular carcinoma

Gui WenFang, Zhu QingJing, Yang Ling

2018, 34(12): 2693-2697. DOI: 10.3969/j.issn.1001-5256.2018.12.040

Abstract(1548)

PDF (1635KB)(389) Cited By (4)

Abstract:
With the increase in the incidence rates of obesity and other metabolic syndromes, nonalcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases. More and more studies have shown that NAFLD is one of the risk factors for hepatocellular carcinoma (HCC) , but the me...

Application value of imaging diagnosis in nonalcoholic fatty liver disease

Hong Jia, Shi YiWen, Wu XiaoNing, You Hong

2018, 34(12): 2698-2701. DOI: 10.3969/j.issn.1001-5256.2018.12.041

Abstract(1804)

PDF (1615KB)(382) Cited By (15)

Abstract:
Nonalcoholic fatty liver disease (NAFLD) is a chronic disease with complex lesions, and it is difficult to determine the clinical stage. Liver biopsy is still the gold standard for the diagnosis of NAFLD; however, its clinical application is limited by various factors.Therefore, noninvasive methods ...

The economic burden and risk factors in inflammatory bowel disease with nonalcoholic fatty liver disease

Feng Gong, Mi Man, Li XuePing, He Na, Chen ZiJun, Niu ChunYan

2018, 34(12): 2702-2706. DOI: 10.3969/j.issn.1001-5256.2018.12.042

Abstract(1705)

PDF (1635KB)(321) Cited By (6)

Abstract:
Nonalcoholic fatty liver disease (NAFLD) is a disease affecting about a quarter of the general population and has become the most important chronic liver disease in China and Western countries, causing huge medical and economic burdens. The prevalence rate of NAFLD is estimated to be as high as 40% ...