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CN 22-1108/R
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2016 No. 12

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Editorial
Application of magnetic resonance imaging in hepatobiliary diseases and related challenges
Wang XiaoMing, Wang YueRen
2016, 32(12): 2231-2235. DOI: 10.3969/j.issn.1001-5256.2016.12.002
Abstract(1936) PDF (1683KB)(620)
Abstract:
Hepatobiliary diseases are highly prevalent and diverse in China. Besides chronic viral hepatitis,the incidence of non- alcoholic fatty liver disease and alcohol liver disease has been increasing gradually year by year. In recent years,with the improvement of magnetic resonance software and hardware...
Discussions by experts
Role of endoscopic ultrasonography in treatment and prognostic evaluation of esophageal and gastric varices
Li Shuang, Lu Wei, Cui ShuBo, Li Jia, Hu DongSheng, Zhou YongHe, Yao ShengJuan
2016, 32(12): 2268-2272. DOI: 10.3969/j.issn.1001-5256.2016.12.008
Abstract(2605) PDF (2263KB)(590)
Abstract:
Through a comprehensive evaluation of collateral circulation establishment in portal hypertension,endoscopic ultrasonography( EUS) not only helps to predict and evaluate the risks of first bleeding from esophageal and gastric varices and recurrence and rebleeding after treatment,but also guides and ...
Research advances in the application of specific molecular probes for positron emission tomography in diagnosis of early-stage liver fibrosis
Yang MengYi, Xu XiangXin, Xin Jun
2016, 32(12): 2273-2276. DOI: 10.3969/j.issn.1001-5256.2016.12.009
Abstract(2324) PDF (1457KB)(443)
Abstract:
Liver fibrosis is a symbolic process of many chronic liver diseases,and liver biopsy is the gold standard for the diagnosis of liver fibrosis in clinical practice. At present,there is a lack of effective methods for the noninvasive diagnosis of early- stage liver fibrosis. The process of liver fibro...
Role of functional magnetic resonance imaging in evaluating the therapeutic effect of transcatheter arterial chemoembolization in hepatocellular carcinoma
Luo YongHeng, Xiao EnHua
2016, 32(12): 2277-2281. DOI: 10.3969/j.issn.1001-5256.2016.12.010
Abstract(2285) PDF (1484KB)(449)
Abstract:
Transcatheter arterial chemoembolization( TACE) is the first- line treatment for unresectable hepatocellular carcinoma( HCC).Postoperative follow- up helps to determine tumor survival and necrosis timely and accurately and plays an important role in evaluating therapeutic outcome,guiding future trea...
Imaging diagnosis of liver tumors in children
Sun XueFeng, Yuan XinYu
2016, 32(12): 2282-2288. DOI: 10.3969/j.issn.1001-5256.2016.12.011
Abstract(2421) PDF (2340KB)(486)
Abstract:
Primary liver tumors in children are not rare,and the incidence of malignant liver tumors in children ranks third of all malignant abdominal tumors in children,with the features of a high rate of malignancy,a high incidence of congenital tumors,and a specific age of onset.Liver tumors in children of...
Imaging feature of rare liver neoplasms
Li XinMing, Quan XianYue, Tan ShuPing
2016, 32(12): 2289-2294. DOI: 10.3969/j.issn.1001-5256.2016.12.012
Abstract(2803) PDF (1464KB)(511)
Abstract:
Various primary and secondary tumors are commonly seen in the liver and have different histological types,but some types of tumors are rare. Computed tomography( CT) and magnetic resonance imaging( MRI) can show the size,morphology,and density or signal of intrahepatic lesions,their association with...
Imaging evaluation of complications after liver transplantation
Wang MingYue, Lu ZhiYan
2016, 32(12): 2295-2299. DOI: 10.3969/j.issn.1001-5256.2016.12.013
Abstract(2211) PDF (1466KB)(452)
Abstract:
Liver transplantation is an effective treatment for end- stage chronic liver diseases and acute liver failure. With the rapid development of surgical techniques,organ preservation technology,and pharmacotherapy,patients' survival rates are improved constantly. However,postoperative complications are...
Clinical effect of brachytherapy with ~(125)I seed implantation in treatment of malignant hepatopancreatobiliary tumors
Jiang Xu, Yang JiJin, Li Hui
2016, 32(12): 2300-2304. DOI: 10.3969/j.issn.1001-5256.2016.12.014
Abstract(2740) PDF (1470KB)(469)
Abstract:
Malignant hepatopancreatobiliary tumors are highly malignant and have poor prognosis.~(125)I seed implantation combined with other minimally invasive therapies for radical treatment of early liver cancer has achieved a good clinical effect in preventing early recurrence after liver cancer surgery. I...
Imaging diagnosis of pancreatic cancer and preoperative imaging evaluation of resectability and staging
Chen Lu, Yu RiSheng
2016, 32(12): 2305-2311. DOI: 10.3969/j.issn.1001-5256.2016.12.015
Abstract(2576) PDF (1727KB)(458)
Abstract:
Pancreatic cancer is an invasive malignant tumor with a high mortality rate. As the preferred imaging method for pancreatic imaging,multi- slice CT angiography can evaluate the presence or absence,extent,and degree of invasion of peripancreatic major vessels to provide reliable evidence for tumor st...
Original articles_Viral hepatitis
Preparation of human hepatitis B virus monoclonal antibodies using single cell RT-PCR
Li TeTe, Wu Jing, Lu: XinPing, Zhou Hao, Chen JingTao
2016, 32(12): 2312-2316. DOI: 10.3969/j.issn.1001-5256.2016.12.016
Abstract(2072) PDF (1855KB)(436)
Abstract:
Objective To establish the system for the isolation of peripheral single antibody- secreting cells( ASCs) and single cell RT-PCR system,and to clone highly specific human hepatitis B monoclonal antibody efficiently and rapidly. Methods Three patients with HBV infection in the recovery stage were enr...
Change in peripheral blood CD4~+ regulatory T cells and its association with antiviral effect in patients with chronic hepatitis C
Guo FeiBo
2016, 32(12): 2317-2321. DOI: 10.3969/j.issn.1001-5256.2016.12.017
Abstract(374) PDF (227KB)(33)
Abstract:
Objective To investigate the change in peripheral blood CD4~+regulatory T( Treg) cells and its association with antiviral effect in patients with chronic hepatitis C( CHC). Methods A total of 85 CHC patients who completed standard antiviral therapy and follow- up in The First People's Hospital of Ti...
Original articles_Liver fibrosis and liver cirrhosis
Clinical value of FibroScan in diagnosis of moderate-to-severe liver fibrosis in patients with chronic hepatitis B
Wang Lin, Xue Fang, Shi YuXin
2016, 32(12): 2322-2325. DOI: 10.3969/j.issn.1001-5256.2016.12.018
Abstract(2479) PDF (1523KB)(491)
Abstract:
Objective To investigate the clinical value of transient elastography( FibroScan) in the diagnosis of moderate- to- severe liver fibrosis in patients with chronic hepatitis B( CHB). Methods A total of 245 patients with pathologically confirmed CHB by liver biopsy who underwent FibroScan and serologi...
Association between portal vein pressure drop gradient after transjugular intrahepatic portosystemic shunt and clinical prognosis
Xu ZhengGuo, Zhao YongBing, Zheng YuanYu, Liu En, Yang ShiMing
2016, 32(12): 2326-2330. DOI: 10.3969/j.issn.1001-5256.2016.12.019
Abstract(2118) PDF (1471KB)(541)
Abstract:
Objective To investigate the association between portal vein pressure drop gradient in patients with cirrhotic portal hypertension treated by transjugular intrahepatic portosystemic shunt( TIPS) and clinical prognosis,as well as the ideal range of portal vein pressure drop. Methods A total of 58 pat...
Mechanism of action of 1,25(OH)_2D_3 in influencing the expression of interleukin-17 and macrophage inflammatory protein-3α and inhibiting the formation of liver fibrosis in rats
Li XiaoTian, Yin Yan, Guo YongZe, Zhou LiYun, You ZiXuan
2016, 32(12): 2331-2336. DOI: 10.3969/j.issn.1001-5256.2016.12.020
Abstract(2006) PDF (2143KB)(483)
Abstract:
Objective To investigate the changes in the expression of interleukin- 17( IL- 17) and macrophage inflammatory protein- 3α( MIP- 3α) in liver tissue and peripheral blood during the formation of liver fibrosis and the mechanism of action of 1,25( OH)2D3in influencing the IL- 17 pathway and inhibiting...
Original articles_Liver neoplasms
Clinical effect and safety of percutaneous radiofrequency ablation following transcatheter arterial chemoembolization in treatment of primary liver cancer in high-risk locations
Sun Wei, Ding XiaoYan, Chen JingLong
2016, 32(12): 2337-2341. DOI: 10.3969/j.issn.1001-5256.2016.12.021
Abstract(2136) PDF (1689KB)(420)
Abstract:
Objective To investigate the clinical effect and safety of percutaneous radiofrequency ablation( RFA) following transcatheter arterial chemoembolization( TACE) in the treatment of primary liver cancer in high- risk locations. Methods The patients with primary liver cancer in high- risk locations who...
Influence of serum levels of alkaline phosphatase and gamma-glutamyl transpeptidase on the prognosis of patients with primary liver cancer undergoing radiofrequency ablation
Zhu Ge, Zhao LingLing, Qian Lei, Dong YaBing, Zhao HengJun, Cui JiuWei, Wang NanYa
2016, 32(12): 2342-2346. DOI: 10.3969/j.issn.1001-5256.2016.12.022
Abstract(2054) PDF (1765KB)(472)
Abstract:
Objective To investigate the influence of serum levels of alkaline phosphatase( ALP) and gamma- glutamyltransferase( GGT)before treatment on the prognosis of patients with primary liver cancer undergoing radiofrequency ablation. Methods A total of 165 patients with pathologically or clinically confi...
Synergistic effect of intervention of glypican-3 gene transcription combined with antitumor drugs in inhibiting hepatoma cell proliferation
Yang Jie, Yao Min, Wang Li, Dong ZhiZhen, Gu JuanJuan, Qiu LiWei, Zhang Wei, Yao DengFu
2016, 32(12): 2347-2352. DOI: 10.3969/j.issn.1001-5256.2016.12.023
Abstract(2080) PDF (1990KB)(406)
Abstract:
Objective To investigate the inhibitory effect of intervention of glypican- 3( GPC3) gene transcription combined with antitumor drugs on hepatoma cell proliferation. Methods Four types of GPC3- shRNA plasmids were established and transfected into HepG2 hepatoma cells. Quantitative real- time PCR and...
Original articles_Biliary diseases
Application of endoscopic retrograde cholangiopancreatography in treatment of extrahepatic biliary adenoma
Zhou HaiXiang, Dong XiaoYun, Bu Ping, Xiang XiaoXing, Xu XiaoLing, Chen ChaoWu
2016, 32(12): 2353-2355. DOI: 10.3969/j.issn.1001-5256.2016.12.024
Abstract(1519) PDF (1602KB)(465)
Abstract:
Objective To investigate the clinical features of extrahepatic biliary adenoma and the role of endoscopic retrograde cholangiopancreatography( ERCP) in the diagnosis and treatment of extrahepatic biliary adenoma. Methods A retrospective analysis was performed for the clinical manifestations,imaging ...
Case reports
Li YunQian, Chen Fan, Liu Yang, Yu HongQuan, Jin RiHua, Wu XinMin
2016, 32(12): 2364-2366. DOI: 10.3969/j.issn.1001-5256.2016.12.027
Abstract(2114) PDF (2248KB)(467)
Abstract:
Ma PanPan, Jiang XiaoMing, Han DongFeng, Lin JieYu, Liu Fang, Liu XiaoLiang
2016, 32(12): 2367-2368. DOI: 10.3969/j.issn.1001-5256.2016.12.028
Abstract(1679) PDF (1441KB)(421)
Abstract:
Cong TingTing, Liu SiQi, Jia ShengNan, Pan LiuLan
2016, 32(12): 2369-2370. DOI: 10.3969/j.issn.1001-5256.2016.12.029
Abstract(1719) PDF (1433KB)(452)
Abstract:
Wang Long, Zheng PengFei, An HuiMeng, Peng Wei, Cao HongTai, Cheng ZhiBin
2016, 32(12): 2371-2372. DOI: 10.3969/j.issn.1001-5256.2016.12.030
Abstract(1805) PDF (1538KB)(451)
Abstract:
Reviews
PD-1/PD-L signaling pathway in chronic hepatitis B
Tao LiLin, Lai Xin, Wei Jia
2016, 32(12): 2373-2378. DOI: 10.3969/j.issn.1001-5256.2016.12.031
Abstract(1704) PDF (1498KB)(417)
Abstract:
Hepatitis B is one of the major diseases that affect the health of Chinese people,and chronic hepatitis B virus( HBV) infection can lead to disease progression. Programmed death- 1( PD- 1) discovered in recent years is an important coordinated stimulus molecule which belongs to the B7/CD28 family. A...
Ultrasound elastography for evaluation of classification of liver fibrosis
Ge Na, He Qian
2016, 32(12): 2379-2382. DOI: 10.3969/j.issn.1001-5256.2016.12.032
Abstract(1835) PDF (1467KB)(475)
Abstract:
Liver fibrosis is the important stage of most liver diseases,and early and accurate diagnosis of classification of liver fibrosis plays an important role in developing individualized treatment regimens and reducing mortality rates. Ultrasound elastography has become popular in clinical physicians du...
Effect of splenectomy on liver cirrhosis and related surgical issues
Kong DeGang, Lu ShiChun
2016, 32(12): 2383-2386. DOI: 10.3969/j.issn.1001-5256.2016.12.033
Abstract(2340) PDF (1461KB)(467)
Abstract:
Patients with liver fibrosis and cirrhosis experience certain changes in spleen morphology and function,and there is always a controversy over whether to perform splenectomy in patients with liver cirrhosis. As a surgical treatment of recurrent portal hypertension complicated by esophagogastric vari...
Current status of research on microRNA associated with colorectal cancer liver metastasis
Wang DongXu, Huo TingTing, Tian YaoWen, Zhao Lei
2016, 32(12): 2387-2390. DOI: 10.3969/j.issn.1001-5256.2016.12.034
Abstract(2155) PDF (1465KB)(446)
Abstract:
Tumor metastasis is a complicated process with multiple steps,and liver metastasis is the most common metastatic mode of colorectal cancer. Deep understanding and study of metastatic mechanism helps to find solutions for colorectal cancer liver metastasis. Recent studies have shown that microRNA are...
Role of intestinal mucosal barrier in the development and progression of nonalcoholic fatty liver disease
Zhang YuanYuan, Li Jing, Chi YuJing, Su Lin, Liu YuLan
2016, 32(12): 2391-2394. DOI: 10.3969/j.issn.1001-5256.2016.12.035
Abstract(2319) PDF (1463KB)(455)
Abstract:
The incidence of non- alcoholic fatty liver disease( NAFLD) has been increasing year by year in China. Intestinal mucosa is the largest organ for bacterial storage,and intestinal mucosal barrier includes biological barrier,mechanical barrier,immunological barrier,and chemical barrier. This article i...
Role of the Mac-2 binding protein glycosylation isomer in diagnosis of chronic liver diseases
Yang YiLiang, Cui YuanYuan, Hu Yue, Xu HongQin, Pan Yu
2016, 32(12): 2395-2398. DOI: 10.3969/j.issn.1001-5256.2016.12.036
Abstract(2707) PDF (1461KB)(521)
Abstract:
Mac- 2 binding protein is a type of glycoprotein which exits in cytoplasm,interstitial fluid,and plasma and is secreted by a variety of tissues and organs. Mac- 2 binding protein glycosylation isomer( M2BPGi) is synthesized by hepatic stellate cells. This article briefly introduces the research adva...
Research advances in signaling pathways involved in liver regeneration mediated by oval cells
Zhong XiaoMao, Han BaoSheng
2016, 32(12): 2399-2402. DOI: 10.3969/j.issn.1001-5256.2016.12.037
Abstract(2341) PDF (1524KB)(443)
Abstract:
The apoptosis,necrosis,and senescence of hepatocytes are closely associated with the activation and proliferation of oval cells,and in addition,liver regeneration mediated by oval cells is an important part of regeneration after liver injury. Currently,studies have shown that a variety of cytokines,...
Application and role of fibrates in treatment of primary biliary cholangitis and related mechanisms
Wu LiHong, Han Ying
2016, 32(12): 2403-2406. DOI: 10.3969/j.issn.1001-5256.2016.12.038
Abstract(2468) PDF (1469KB)(508)
Abstract:
Primary biliary cholangitis( PBC) is an autoimmune chronic cholestatic liver disease. Ursodeoxycholic acid( UDCA) is the only safe and effective drug for PBC approved by FDA. To date,there is no unified therapeutic regimen for patients with suboptimal response to UDCA. Fibrates are a class of synthe...
Wang MingMing
2016, 32(12): 2230-2230. DOI: 肝胆病杂志 2016,32(12),2230
Abstract(878) PDF (925KB)(392)
Abstract:
Expert consensus on clinical application of hepatobiliary-specific MRI contrast agent Gd-EOB-DTPA
Abdominal Study Group, Chinese Society of Radiology, Chinese Medical Association
2016, 32(12): 2236-2241. DOI: 10.3969/j.issn.1001-5256.2016.12.003
Abstract(2585) PDF (1488KB)(572)
Abstract:
Expert consensus on antiviral therapy for chronic hepatitis B with renal injury or high risk of renal injury
Chinese Society of Hepatology, Chinese Medical Association
2016, 32(12): 2242-2247. DOI: 10.3969/j.issn.1001-5256.2016.12.004
Abstract(271) PDF (274KB)(232)
Abstract:
Zhang Ying, Zhang FuKui
2016, 32(12): 2248-2257. DOI: 10.3969/j.issn.1001-5256.2016.12.005
Abstract(2032) PDF (1519KB)(489)
Abstract:
Interpretation and analysis of EASL recommendations on treatment of hepatitis C 2016
Shen ShanShan, Dai MingJia, Yan XueBing
2016, 32(12): 2258-2262. DOI: 10.3969/j.issn.1001-5256.2016.12.006
Abstract(2172) PDF (1464KB)(496)
Abstract:
Jin Lei, Li JingJing, Gao YuFeng
2016, 32(12): 2263-2267. DOI: 10.3969/j.issn.1001-5256.2016.12.007
Abstract(228) PDF (215KB)(106)
Abstract:
Clinical types and features of chronicity of drug-induced liver injury
Liang Shan, Fan ZuoPeng, Nie Wei, Chou LiXia, Chen Jie, Lin Wei, Liu YiRong, Zhang Jing, Hu ZhongJie
2016, 32(12): 2356-2359. DOI: 10.3969/j.issn.1001-5256.2016.12.025
Abstract(2261) PDF (1491KB)(469)
Abstract:
Objective To investigate the clinical types and features of chronicity of drug- induced liver injury( DILI). Methods The patients who were diagnosed with DILI in Beijing You An Hospital,Capital Medical University from January 2011 to December 2013 were screened,and a retrospective analysis was perfo...
Changes in serum markers of iron metabolism and their clinical significance in patients with nonalcoholic fatty liver disease
Ou Qiang, Wang Yang, Xu YanHua, Ning HuiMing, Huang Ling, Tang Qun
2016, 32(12): 2360-2363. DOI: 10.3969/j.issn.1001-5256.2016.12.026
Abstract(507) PDF (192KB)(126)
Abstract:
Objective To investigate the changes in the serum markers of iron metabolism and their clinical significance in patients with nonalcoholic fatty liver disease( NAFLD). Methods A total of 68 NAFLD patients who were admitted to The Eighth People' s Hospital of Shanghai from July 2014 to April 2016 wer...
2016, 32(12): 2407-2418. DOI: 肝胆病杂志 2016,32(12),2407-2418
Abstract(19) PDF (1030KB)(47)
Abstract:
    

The first journal specializing in hepatobiliary and pancreatic diseases in China

Supervisor：Ministry of Education of the People's Republic of China

Sponsor：Jilin University

Academic Support: Chinese Society of Hepatology，Chinese Medical Association

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