2015 No. 5

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Editorial

Emphasis on neoadjuvant therapy for “resectable”pancreatic cancer

Liu Chang, Yang YinMo

2015, 31(5): 645-648. DOI: 10.3969/j.issn.1001-5256.2015.05.001

Abstract(2079)

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Abstract:
The treatment concept for pancreatic cancer is being transferred from“surgery first”to MDT model.The postoperative adjuvant treatment of pancreatic cancer can significantly improve the prognosis of patients and has become the standardized diagnostic and treatment practice; the value and significance...

Therapeutic guidelines

Updated key points and clinical pathway for NCCN Clinical Practice Guidelines in Oncology: pancreatic adenocarcinoma (Version2.2015)

Li XiaoQing, Qian JiaMing

2015, 31(5): 649-653. DOI: 10.3969/j.issn.1001-5256.2015.05.002

Abstract(236)

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The discussion on the surgical issues related to NCCN clinical practice guidelines in oncology for pancreatic adenocarcinoma ( V2.2015 )

Zhang TaiPing, Cao Zhe, Zhao YuPei

2015, 31(5): 654-656. DOI: 10.3969/j.issn.1001-5256.2015.05.003

Abstract(240)

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Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT) in 2015

Tu ChuanTao, Wang JiYao

2015, 31(5): 657-658. DOI: 10.3969/j.issn.1001-5256.2015.05.004

Abstract(2820)

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Sinusoidal obstruction syndrome/veno-occlusive disease: current situation and perspectives-a position statement from the European Society for Blood and Marrow Transplantation (EBMT) in 2015

Wang XiaoXi, Qi XingShun, Guo XiaoZhong

2015, 31(5): 659-664. DOI: 10.3969/j.issn.1001-5256.2015.05.005

Abstract(269)

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Discussions by experts

Progress in diagnosis and treatment of autoimmune pancreatitis

Yin Tao, Wu HeShui

2015, 31(5): 665-667. DOI: 10.3969/j.issn.1001-5256.2015.05.006

Abstract(2660)

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Abstract:
Autoimmune pancreatitis(AIP) is a special type of chronic pancreatitis that originates from an autoimmune-mediated mechanism.AIP has unique radiological,serological,and histopathological features,often accompanied by peripancreatic lesions.AIP may be easily confused with pancreatic cancer and cholan...

Treatment of pancreatic neuroendocrine tumor with liver metastases

Li Zhao, Zhu JiYe

2015, 31(5): 668-670. DOI: 10.3969/j.issn.1001-5256.2015.05.007

Abstract(3134)

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Abstract:
Pancreatic neuroendocrine tumor(pNET) is a rare type of pancreatic tumors.The incidence of pNET shows a gradually increasing trend in recent years.The most common organ of distant metastases is the liver.Surgical resection is still the optimal treatment for resectable,well-differentiated liver metas...

Progress in additional new techniques of endoscopic ultrasound in treatment of pancreatic tumors

Hou XiaoJia, Jin ZhenDong

2015, 31(5): 671-673. DOI: 10.3969/j.issn.1001-5256.2015.05.008

Abstract(2715)

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Abstract:
With the development of endoscopic techniques,the recent emergence of additional techniques of endoscopic ultrasound(EUS)have provided a novel means for the diagnosis and treatment of pancreatic tumors,which has received more and more attention and recognition from around the world.This article revi...

Surgical treatment of pancreatic cystic neoplasms

Wu Zheng, Wang Zheng, Xu QinHong

2015, 31(5): 674-677. DOI: 10.3969/j.issn.1001-5256.2015.05.009

Abstract(2717)

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Abstract:
Cystic neoplasms of the pancreas are rare lesions,usually without typical clinical manifestations.This article summarizes the clinicopathological features and surgical treatment of common cystic neoplasms of the pancreas,including serous cystic neoplasm(SCN),mucinous cystic neoplasm(MCN),intraductal...

Diagnosis of pancreatic cancer based on biological information of saliva: an analysis of current status

Ni Rui, Wang ManCai, Zhang YouCheng

2015, 31(5): 678-680. DOI: 10.3969/j.issn.1001-5256.2015.05.010

Abstract(2779)

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Abstract:
Pancreatic cancer is one of common malignant tumors in the digestive system.There is still no effective means for the early diagnosis of pancreatic cancer.As a mixture of oral gland secretion and oral mucosal transudate,saliva contains abundant biological information including microorganisms,protein...

Application of minimally invasive technique in surgical treatment of pancreatic diseases

Zhang YiXi, Qiao Xin, Liu Bin, Qiao ShiXing

2015, 31(5): 681-683. DOI: 10.3969/j.issn.1001-5256.2015.05.011

Abstract(2485)

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Abstract:
In recent years,with the rapid development of minimally invasive concept,from laparoscopic operation to three-dimension laparoscopic technique and to robotic surgical system,treatment modalities have changed a lot.Pancreatic diseases,including multiple lesions,have different prognoses.An appropriate...

Original articles_Pancreatic diseases

A clinical study of endoscopic retrograde cholangiopancreatography in treatment of chronic pancreatitis

Yang Liu, Zhang JinKun, Zhou ChunXiao

2015, 31(5): 684-686. DOI: 10.3969/j.issn.1001-5256.2015.05.012

Abstract(2581)

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Abstract:
Objective To explore the value of endoscopic retrograde cholangiopancreatography(ERCP) in the treatment of chronic pancreatitis(CP).Methods Thirty patients with CP who underwent ERCP from January 2008 to December 2012 were retrospectively analyzed.Serum amylase levels were determined before and at 2...

Clinical effect of laparoscopic common bile duct exploration combined with endobiliary drainage in treatment of acute biliary pancreatitis

Sun JinChun

2015, 31(5): 687-690. DOI: 10.3969/j.issn.1001-5256.2015.05.013

Abstract(2473)

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Abstract:
Objective To evaluate the clinical effect of laparoscopic common bile duct exploration combined with endobiliary drainage in the treatment of acute biliary pancreatitis.Methods A retrospective analysis was performed on the clinical data of 90 patients with acute biliary pancreatitis admitted to our ...

Clinical significance of C-reactive protein for assessment and outcomes of severe acute pancreatitis

Ren LiNan, Guo XiaoZhong, Li HongYu, Zhao JianCheng

2015, 31(5): 691-693. DOI: 10.3969/j.issn.1001-5256.2015.05.014

Abstract(2664)

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Abstract:
Objective To study the change in serum CRP level in patients with severe acute pancreatitis(SAP),and to explore its clinical significance in predicting outcomes and assessing the severity of SAP.Methods A retrospective analysis was performed on 52 SAP patients with complete case data and admitted to...

Experience in surgical treatment of 19 patients with pancreatic duct stones

Zhang YaHui, Yi ZhuJun, Gong JianPing, Xiong Bin

2015, 31(5): 694-696. DOI: 10.3969/j.issn.1001-5256.2015.05.015

Abstract(2470)

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Original articles_Viral hepatitis

Efficacy of pegylated interferon α-2a in HBe Ag-negative chronic hepatitis B patients and its influencing factors

Liu ZhiHua, He HaiTang, Hu Jing, Fu QunXiang, Luo KangXian

2015, 31(5): 697-701. DOI: 10.3969/j.issn.1001-5256.2015.05.016

Abstract(2432)

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Abstract:
Objective To observe the efficacy of pegylated interferon α-2a(PEG-IFN α-2a) in HBe Ag-negative chronic hepatitis B(CHB) patients and to analyze its influencing factors.Methods One hundred and three HBe Ag-negative CHB patients,who visited Department of Infectious Diseases,Nanfang Hospital,Southern ...

Changes in peripheral plasma concentrations of macrophage migration inhibitory factor,interleukin-17,and interleukin-10 and their correlations with HBV DNA load in chronic HBV carriers

Li CaiDong, Yang YongWei, Li HuiJun, Tian PengFei, Wu Bin

2015, 31(5): 702-705. DOI: 10.3969/j.issn.1001-5256.2015.05.017

Abstract(2413)

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Abstract:
Objective To determine the changes in peripheral plasma concentrations of macrophage migration inhibitory factor(MIF),interleukin-17(IL-17),and interleukin-10(IL-10) in HBV carriers and their correlations with liver function or HBV DNA load of HBV carriers.Methods Fasting plasma samples were collect...

Analysis of influencing factors for short-term outcome in patients with hepatitis B virus-related acute-on-chronic liver failure

Zhang Xin, Gan QiaoRong, Wang Ning, Pan Chen

2015, 31(5): 706-710. DOI: 10.3969/j.issn.1001-5256.2015.05.018

Abstract(2582)

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Abstract:
Objective To investigate the effects of antiviral drugs,lamivudine(LAM) and entecavir(ETV),on the short-term outcome in patients with hepatitis B virus(HBV)-related acute-on-chronic liver failure(ACLF).Methods The demographic and clinical data of 445 patients with HBV-related ACLF(LAM∶ ETV,333∶ 112)...

Count of peripheral blood dendritic cells and its clinical significance in patients with acute-on-chronic hepatitis B liver failure

Jia Lin, Li Juan, Zhu YueKe, Zhao Juan, Liu HaiXia, Duan ZhongHui, Ren MeiXin, Meng QingHua

2015, 31(5): 711-715. DOI: 10.3969/j.issn.1001-5256.2015.05.019

Abstract(2598)

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Abstract:
Objective To investigate the relationship between the count of peripheral blood dendritic cells(DCs) and clinical outcome in patients with acute-on-chronic hepatitis B liver failure(ACHBLF).Methods This study included 70 patients with ACHBLF admitted to our hospital from June 2010 to September 2014....

Characteristics of energy metabolism in patients with chronic hepatitis C

Zhao Juan, Liu YaZhou, Dai Lu, Wang JinHuan, Li Juan, Yu HongWei, Meng QingHua

2015, 31(5): 716-720. DOI: 10.3969/j.issn.1001-5256.2015.05.020

Abstract(2526)

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Abstract:
Objective To characterize the energy metabolism in patients with chronic hepatitis C(CHC) and to provide a basis for clinical nutrition intervention.Methods This study included 70 cases of chronic hepatitis C(CHC) admitted to Beijing You An Hospital affiliated to Capital Medical University from Dece...

Original articles_Liver neoplasms

Analysis of quality of life and prognosis in patients with HBV-related end-stage hepatocellular carcinoma after antiviral therapy

Li Peng, Zhai Yun, Zhang ShiBin, Li Lei, Ding HuiGuo

2015, 31(5): 721-724. DOI: 10.3969/j.issn.1001-5256.2015.05.021

Abstract(2399)

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Abstract:
Objective To investigate the acquired benefit of antiviral therapy in addition to routine treatment regimen including hepatoprotective internal medicine in patients with hepatitis B virus(HBV)-related end-stage hepatocellular carcinoma(HCC).Methods A total of 105 end-stage HCC patients who were admi...

Intervention of raltitrexed combined with epirubicin in hepatic arterial infusion and embolization in treatment of primary liver cancer

Wang BaoXin, Wu ZhenMing, Zhang Rui, Hu XinHua, Zou QingHua, Fan YiFeng, Xing HongJian, Xiao FangFang, Qi XiuHeng

2015, 31(5): 725-728. DOI: 10.3969/j.issn.1001-5256.2015.05.022

Abstract(2540)

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Abstract:
Objective To evaluate the therapeutic effect of intervention of raltitrexed combined with epirubicin in hepatic arterial infusion and embolization in the treatment of advanced primary liver cancer.Methods A total of 80 patients with advanced primary liver cancer who were admitted to the Central Hosp...

Patients with liver FNH and HCC patients with negative AFP: plain and dynamic enhanced MRI and CT findings

Li MingTong

2015, 31(5): 729-732. DOI: 10.3969/j.issn.1001-5256.2015.05.023

Abstract(2593)

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Abstract:
Objective To investigate plain and dynamic enhanced magnetic resonance imaging(MRI) and computed tomography(CT)findings in patients with focal nodular hyperplasia(FNH) of the liver and hepatocellular carcinoma(HCC) patients with negative alpha-fetoprotein(AFP).Methods A statistical analysis was perf...

Analysis of association between HSP70 expression in tumor tissues and clinicopathological characteristics of HBV-related hepatocellular carcinoma

Gao JiaLin, Yang ZongGuo, Chen XiaoRong, Xu QingNian, Lu YunFei

2015, 31(5): 733-736. DOI: 10.3969/j.issn.1001-5256.2015.05.024

Abstract(2479)

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Abstract:
Objective To investigate the relationship between heat shock protein 70(HSP70) expression and clinicopathological characteristics of hepatitis virus B(HBV)-induced hepatocellular carcinoma(HCC).Methods Statistical analysis was conducted to explore the association between the data of HSP70 obtained f...

Original articles_Biliary diseases

Efficacy of percutaneous intraductal radiofrequency ablation combined with biliary stenting in treatment of malignant biliary obstruction

Zhang Kai, Zhang MengFan, Ren JianZhuang, Huang GuoHao, Wang YanLi, Duan XuHua, Chen PengFei, Han XinWei

2015, 31(5): 737-740. DOI: 10.3969/j.issn.1001-5256.2015.05.025

Abstract(2352)

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Abstract:
Objective To investigate the safety and feasibility of percutaneous intraductal radiofrequency ablation(palliative therapy) in the treatment of malignant obstructive jaundice.Methods This study included 20 patients with unresectable malignant obstructive jaundice,who were treated in the First Affili...

Experience in treatment of 326 patients with gallstones

Zhang HePing

2015, 31(5): 741-744. DOI: 10.3969/j.issn.1001-5256.2015.05.026

Abstract(2354)

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Abstract:
Objective To investigate the feasibility of clinical staging and standardization of therapy for patients with gallstones.Methods The clinical data of 326 cases of gallstones treated in our hospital from January 2012 to December 2013 were collected.Appropriate surgical procedures were selected based ...

Original articles_Others

Clinical efficacy of terlipressin in treatment of type II hepatorenal syndrome

Ding XiaoHong, Gu JianYing

2015, 31(5): 745-748. DOI: 10.3969/j.issn.1001-5256.2015.05.027

Abstract(2521)

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Abstract:

Objective To investigate the clinical efficacy of domestic terlipressin in the treatment of type II hepatorenal syndrome(HRS-II).Methods A total of 25 HRS-II patients admitted to our hospital from November 2011 to June 2014 were recruited into the treatment group,and 28 HRS-II patients treated with ...

Value of Gd-EOB-DTPA-enhanced MRI in assessing liver function

Wang LiLi, Lei JunQiang, Guo JiGang, Yin Liang, Zhai YaNan, Li JinKui, Chen Hong, Guo ShunLin

2015, 31(5): 749-753. DOI: 10.3969/j.issn.1001-5256.2015.05.028

Abstract(2856)

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Abstract:

Objective To explore the value of magnetic resonance imaging(MRI) specifically enhanced with gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid(Gd-EOB-DTPA) in assessing the liver function in general population.Methods Upper abdominal MRI images and Gd-EOB-DTPA-enhanced images,as well as so...

Levels and clinical significance of serum 25-hydroxy vitamin D in patients with chronic liver disease

Yang WeiMin, Xin GuiJie, Ding ShengNan

2015, 31(5): 754-757. DOI: 10.3969/j.issn.1001-5256.2015.05.029

Abstract(2551)

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Abstract:

Objective To investigate the levels and clinical significance of serum 25-hydroxy vitamin D[25(OH) D] in patients with chronic liver disease.Methods A total of 153 hospitalized patients with chronic liver disease in the First Affiliated Hospital of Jilin University from June 2012 to September 2013 w...

Laboratory analysis of hemolytic jaundice

Li HongPing, Li PeiPei, Zhu ZhaoJun, Zhu HuiJun, Li Xian

2015, 31(5): 758-761. DOI: 10.3969/j.issn.1001-5256.2015.05.030

Abstract(3920)

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Abstract:

Objective To provide a basis for clinical differential diagnosis of hemolytic jaundice based on laboratory analysis of the characteristics of this disease.Methods A total of 44 patients with hemolytic jaundice,who suffered from hereditary hemolytic disorders or hemolytic disorders with hepatitis vir...

Clinical analysis of bloodstream infections caused by Escherichia coli in elderly patients with hepatobiliary disease

Wang Qian, Bao ChunMei, He WeiPing, Cui EnBo, Zhang WenJin, Fan ZhenPing, Qu Fen

2015, 31(5): 762-765. DOI: 10.3969/j.issn.1001-5256.2015.05.031

Abstract(2584)

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Objective To investigate the clinical characteristics and drug resistance in elderly patients with hepatobiliary disease and bloodstream infections caused by Escherichia coli,and to provide a basis for clinical therapy.Methods A retrospective analysis was performed on the clinical characteristics an...

A study of the relationship between EBV DNA and EBV antibody levels

Lu HaiYing, Wei XiuQin, Xu XiaoYuan, Yu YanYan, Wu ChiHong, Liu Dan

2015, 31(5): 766-770. DOI: 10.3969/j.issn.1001-5256.2015.05.032

Abstract(2742)

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Abstract:

Objective To study the relationship between Epstein-Barr virus(EBV) DNA and EBV antibody levels.Methods A retrospective study was conducted on 143 patients who underwent EBV DNA testing in serum and lymphocytes from January to August,2014.The clinical data,including age,sex,blood routine and biochem...

Case reports

Tang ShanHong, He Xuan, Wang Zhao, He QianWen, Zhou XiaoLei, Li HongYong, Ceng WeiZheng, Jiang MingDe

2015, 31(5): 771-772. DOI: 10.3969/j.issn.1001-5256.2015.05.033

Abstract(2546)

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Regional portal hypertension induced by oppression of the splenic vein by pancreatic abscess: a report of one case

Tang ShanHong, He QingWei, He QianWen, Liang Yan, Zhou XiaoLei, Li HongYong, Ceng WeiZheng, Jiang MingDe

2015, 31(5): 773-774. DOI: 10.3969/j.issn.1001-5256.2015.05.034

Abstract(2364)

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Drug-induced liver injury caused by treatment of complications after glucocorticoid therapy for panniculitis: a report of one case

Chang BinXia, Teng GuangJu, Sun Ying, Zhao Jun, Zhang Wei, Zou ZhengSheng, Li BaoSen

2015, 31(5): 775-776. DOI: 10.3969/j.issn.1001-5256.2015.05.035

Abstract(2495)

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Successful treatment of hepatitis E with invasive aspergillosis: a report of one case

Li Qiang, Zhuo QiBin, Huang YuXian, Chen Liang

2015, 31(5): 777-779. DOI: 10.3969/j.issn.1001-5256.2015.05.036

Abstract(2367)

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Diagnosis and treatment of mucobilia: a clinical analysis of two cases

Nie ChuanGeng, Peng ShuMei, Xia XiGang

2015, 31(5): 780-782. DOI: 10.3969/j.issn.1001-5256.2015.05.037

Abstract(2359)

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Reviews

Differential diagnosis of autoimmune pancreatitis from pancreatic cancer

Zhang AnYuan, Chen Hao, Zhao Peng, Gong JianPing

2015, 31(5): 783-786. DOI: 10.3969/j.issn.1001-5256.2015.05.038

Abstract(2819)

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Abstract:
Autoimmune pancreatitis(AIP) is a special form of chronic pancreatitis.Although many clinical guidelines for AIP have been carried out,but clinically differentiating AIP from pancreatic cancer remains difficult.Based on some guidelines for AIP and latest relevant literature,this article summarizes t...

Analysis of relationship between demyelinating lesions and myelin basic protein in pancreatic encephalopathy

Huang BoRu, Zhao HaiPing, Hu WenXiu

2015, 31(5): 787-789. DOI: 10.3969/j.issn.1001-5256.2015.05.039

Abstract(2468)

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Abstract:
Pancreatic encephalopathy(PE) is one of the severe complications of severe acute pancreatitis(SAP).Early diagnosis mostly depends on the history of disease as well as clinical symptoms and signs.PE progresses rapidly and is often complicated by multiple organ dysfunction,and it may finally develop i...

Clinical value of circulating micro RNAs in hepatic,biliary and pancreatic carcinomas

Lin Kun, Ci DanWangJiu, Chang ZhiHui, Liu ZhaoYu

2015, 31(5): 790-795. DOI: 10.3969/j.issn.1001-5256.2015.05.040

Abstract(2491)

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Abstract:
Recent research demonstrates that micro RNA is involved in the growth and development as well as the pathophysiological process of various diseases.In the development and progression of carcinomas,micro RNA can function as an oncogene or tumor suppressor depending on the context.Furthermore,the micr...

Application of interferon-free treatment regimen in treatment of chronic hepatitis C in China

Nie HongMing, Chen JianJie, Wang Rong, Shen Hong

2015, 31(5): 796-799. DOI: 10.3969/j.issn.1001-5256.2015.05.041

Abstract(2490)

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Abstract:
With the release of new oral direct-acting antiviral agents(DAAs),the interferon(IFN)-free treatment for hepatitis C comes out,and the clinical efficacy in phase II and III clinical trials is close to cure,which seems to announce the end of the era of hepatitis C.In China,an area of high incidence o...

Research advances in micro RNAs in regulating hepatitis C virus replication and antiviral therapy

Cui XiangHua, Jia JiDong

2015, 31(5): 800-802. DOI: 10.3969/j.issn.1001-5256.2015.05.042

Abstract(2342)

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Abstract:
Hepatitis C virus(HCV) infection is one of the most common causes of chronic hepatitis,liver cirrhosis,and hepatocellular carcinoma.Micro RNAs(mi RNAs),a class of small,non-coding RNA,are involved in a variety of physiological and pathological processes in human bodies.The mechanism by which miRNAs ...

Value of Fibro Scan in noninvasive diagnosis of hepatic steatosis

Chen Jing, Tang Hong

2015, 31(5): 803-805. DOI: 10.3969/j.issn.1001-5256.2015.05.043

Abstract(2615)

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Abstract:
Early diagnosis and timely treatment of hepatic steatosis is very important for controlling the development and improving the prognosis of disease.This paper introduces the controlled attenuation parameter(CAP),a novel non-invasive method to quantitatively assess hepatic steatosis.This paper briefly...

Research progress in controlled attenuation parameter for assessment of fatty liver disease

Lu JiaFa, Fan JianGao

2015, 31(5): 806-809. DOI: 10.3969/j.issn.1001-5256.2015.05.044

Abstract(2840)

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Abstract:
Controlled attenuation parameter(CAP) is a noninvasive,quantitative,fast,and reliable novel tool for the assessment of fatty liver disease(FLD),and it has been a hotspot in the noninvasive diagnosis of FLD.This paper introduces factors associated with CAP assessing FLD,the cut-off value for the diag...

Structural features and function of clusterin and its role in progression of hepatocellular carcinoma

Qian Qi, Zheng WenJie, Yao DengFu

2015, 31(5): 810-812. DOI: 10.3969/j.issn.1001-5256.2015.05.045

Abstract(1695)

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Abstract:
Hepatocellular carcinoma(HCC) is one of the most common malignant tumors in China,with a very complex mechanism of development and progression.Clusterin(CLU) has been confirmed to play an important role in the development and progression of HCC.This paper reviews the molecular structure and biologic...

Research progress in hemostatic techniques during partial hepatectomy

Xu YanZhe, Ding YouMing, Wang Bin, Xu JunHui

2015, 31(5): 813-815. DOI: 10.3969/j.issn.1001-5256.2015.05.046

Abstract(1792)

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Abstract:
Due to the continuous development of surgical bleeding control technology,partial hepatectomy has been a routine surgery currently.This article reviews the published literature over the past 20 years with particular attention to the progress in bleeding control techniques and applications in partial...

Minimally invasive treatment of extrahepatic bile duct stones

Han WuRiJiLe, Wang ShiJun, Wang Chuang

2015, 31(5): 816-818. DOI: 10.3969/j.issn.1001-5256.2015.05.047

Abstract(1808)

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Abstract:
With the continuous improvement of endoscopic technology and equipment,minimally invasive treatment of bile duct stones becomes increasingly diversified.In this paper,the concept of minimally invasive treatment of bile duct stones,surgical indications and contraindications,surgical methods,and the a...