2014 No. 9

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Editorial

Improving understanding of liver immune function and enhancing research on cell therapy for liver diseases

Jia ZhanSheng, Lian JianQi

2014, 30(9): 839-841. DOI: 10.3969/j.issn.1001-5256.2014.09.001

Abstract(355)

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Abstract:
As an important immune organ, the liver has a unique immune microenvironment, and is one of the important places for innate immunity and adaptive immunity. The liver is closely connected with the immune system through the gut- liver axis and is also the target organ of immune injury. However, the de...

Therapeutic guideline

World Gastroenterology Organisation global guidelines：nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Zhu Peng, Xu Zong, Wang YuMing

2014, 30(9): 842-845. DOI: 10.3969/j.issn.1001-5256.2014.09.002

Abstract(301)

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Abstract:

Discussions by experts

Current status of research on liver innate immunity

Ye ChuanTao, Wei Xin, Zhang Ying

2014, 30(9): 846-850. DOI: 10.3969/j.issn.1001-5256.2014.09.003

Abstract(3157)

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Abstract:
Liver innate immunity plays an important role in the defense against pathogen invasion. The mechanisms of liver innate immunity for defending against pathogen invasion are reviewed, including the special anatomical and physiological characteristics of the liver, the features of innate immune cells i...

Persistent hepatitis virus infection and immune homeostasis

Zhou Yun, Lian JianQi, Jia ZhanSheng

2014, 30(9): 851-854. DOI: 10.3969/j.issn.1001-5256.2014.09.004

Abstract(2933)

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Abstract:
Homeostasis between the host and viruses is naturally maintained. On the one hand, the immune system activates the immune response to kill or eliminate viruses; on the other hand, the immune system controls the immune response to maintain immune homeostasis.The cause of persistent infections with he...

Immunoregulatory effect of multipotent stem cells in liver injury and repair

Cui LiNa, Han Ying

2014, 30(9): 855-859. DOI: 10.3969/j.issn.1001-5256.2014.09.005

Abstract(2892)

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Abstract:
Immunological imbalance is the foundation for the development of liver damage or fibrosis. Therefore, the treatment of liver diseases not only relies on regenerative medicine for cellular replacement, but also depends on immunoregulation. The immunological basis of liver injury and repair, the immun...

Research advances in cellular immunotherapy for primary hepatocellular carcinoma

Zhang Ye, Zhang MingJie, Jia ZhanSheng

2014, 30(9): 860-864. DOI: 10.3969/j.issn.1001-5256.2014.09.006

Abstract(2923)

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Abstract:
The present therapy for primary hepatocellular carcinoma ( HCC) consists of surgery as well as local radiotherapy and chemotherapy. However, the majority of patients are susceptible to recurrence after comprehensive treatment, and the overall treatment outcome is not ideal due to the lack of effecti...

Role of cancer- associated fibroblasts in growth and metastasis of hepatocellular carcinoma

Ma DeNing, Zhu XiaoDong, Tang ZhaoYou

2014, 30(9): 865-868. DOI: 10.3969/j.issn.1001-5256.2014.09.007

Abstract(3118)

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Abstract:
The development and progression of tumors are closely related to the tumor microenvironment. As one of the most important components in tumor microenvironment, cancer- associated fibroblasts ( CAFs) play an important role in carcinogenesis, angiogenesis, invasion, and metastasis of tumors. The role ...

Original articles_Immunity and cell therapy of liver disease

Efficacy and safety of UCB- derived or autologous CIK cells combined with interferon therapy in patients with chronic hepatitis B

Liu Bo, Dong Jing, Zhang JunFei, Song HaiYan, Chen CongXin

2014, 30(9): 869-872. DOI: 10.3969/j.issn.1001-5256.2014.09.008

Abstract(2760)

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Abstract:

Objective To investigate the efficacy and safety of umbilical cord blood ( UCB) - derived or autologous cytokine- induced killer ( CIK) cells combined with interferon therapy in patients with chronic hepatitis B ( CHB) . Methods Thirty CHB patients hospitalized in the Department of Infectious Diseas...

In vitro proliferation capacity and killing efficacy of CIK cells from umbilical cord blood versus patients with chronic hepatitis B

Liu LiWei, Li JiaJia, Zhu LiXin, Liu Bo

2014, 30(9): 873-876. DOI: 10.3969/j.issn.1001-5256.2014.09.009

Abstract(2727)

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Abstract:

Objective To observe the in vitro proliferation capacity and killing efficacy of cytokine- induced killer ( CIK) cells from umbilical cord blood ( UCB) and versus chronic hepatitis B ( CHB) patients of different ages. Methods Five samples of UCB from healthy fetuses born in our hospital from January...

Toll- like receptor 2 drives Th17 cell activation in inflammatory response to hepatitis B virus infection

Zhao RongRong, Yang XiaoFei, Dong Jie, Huang ZhangXing, Zhang Ye, Lian JianQi

2014, 30(9): 877-881. DOI: 10.3969/j.issn.1001-5256.2014.09.010

Abstract(2905)

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Abstract:

Objective To investigate the relationship between Toll- like receptor 2 ( TLR2) in peripheral blood mononuclear cells ( PBMCs) and T helper 17 ( Th17) cells among hepatitis B patients and to provide a theoretical and experimental basis for the study on the mechanism of inflammatory response to hepat...

Changes in peripheral blood T cell subsets and TGFβ and their clinical significance among HBV infection patients with different viral loads

Li CaiDong, Wu Bin, Chen XiLian, Tian PengFei, Duan ZhengJun

2014, 30(9): 882-886. DOI: 10.3969/j.issn.1001-5256.2014.09.011

Abstract(2774)

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Abstract:

Objective To study the changes in peripheral blood T cell subsets among chronic hepatitis B ( CHB) patients and asymptomatic hepatitis B virus ( HBV) carriers ( ASC) , who have different viral loads, and to investigate the correlation of T cell subsets with transforming growth factor beta ( TGFβ) , ...

Effects of splenectomy on peripheral blood Th17 cells and immune function in patients with portal hypertension

Liu ChaoHui, Chen YiJie, Zhang ChengHua

2014, 30(9): 887-890. DOI: 10.3969/j.issn.1001-5256.2014.09.012

Abstract(2812)

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Abstract:

Objective To investigate the effects of splenectomy on peripheral immune cells including Th17 cells in patients with portal hypertension and to analyze the influence of splenectomy on their immune function. Methods Twenty- five portal hypertension patients treated with splenectomy in No. 180 Hospita...

Inhibitory effect of iAPA- DC /CTL on HepG2 xenograft in nude mice

Fu HaiFeng, Zhou WenBo, Ding YouMing, Wang Bin, Xu JunHui, Xu YanZhe

2014, 30(9): 891-894. DOI: 10.3969/j.issn.1001-5256.2014.09.013

Abstract(3253)

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Abstract:

Objective To investigate the inhibitory effect of inhibition of antigen presentation attenuators ( iAPA) - based dendritic cells ( DC) and cytotoxic T lymphocytes ( CTL) ( iAPA- DC/CTL) on HepG2 xenograft in nude mice. Methods Human hepatocarcinoma HepG2 cells were subcutaneously implanted into nude...

Original articles_Viral hepatitis

Analysis of predictors of liver injury stage in chronic HBV infection patients with ALT levels lower than 2 × ULN

Yang Rui, Zhang YaPing, Wang XinHong, Zhu Bin, Zhang GuangWen

2014, 30(9): 895-898. DOI: 10.3969/j.issn.1001-5256.2014.09.014

Abstract(3087)

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Abstract:
Objective To investigate the role of various clinical parameters in predicting liver injury stage in patients with chronic hepatitis B virus ( HBV) infection who had alanine aminotransferase ( ALT) levels lower than 2 times the upper limit of normal ( ULN) . Methods Ultrasound- guided liver biopsy w...

Changing process and development trend of deaths ( mortality) in patients with viral hepatitis in China

He ShuPing, Liang Qin, Zhao Zhen

2014, 30(9): 899-902. DOI: 10.3969/j.issn.1001-5256.2014.09.-015

Abstract(2606)

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Abstract:
Objective To analyze the changing process and development trend of deaths ( mortality) in patients with viral hepatitis after the use of the Internet- based National Notifiable Infectious Disease Reporting System. Methods Descriptive statistical and moving average methods were employed to analyze th...

Original articles_Fatty liver

Risk factors for non- alcoholic fatty liver disease: a multivariate analysis

Pang XueQin, Chen WeiChang, Feng Huang, Tian WenYan

2014, 30(9): 903-905. DOI: 10.3969/j.issn.1001-5256.2014.09.016

Abstract(2510)

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Abstract:

Objective To investigate the risk factors for non- alcoholic fatty liver disease ( NAFLD) and to provide a basis for the prevention of NAFLD. Methods A total of 190 patients with NAFLD who visited the First Affiliated Hospital of Soochow University from January2011 to January 2013 were included in t...

Establishment and management of nonalcoholic fatty liver disease biobank

Chen LiZhen, Zhang HaiYing, Jiang Man, Niu TongHong, Wang Jian, Geng Ning, Liu HaoGang, Xin YongNing, Xuan ShiYing

2014, 30(9): 906-909. DOI: 10.3969/j.issn.1001-5256.2014.09.017

Abstract(2752)

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Abstract:

Objective To investigate the collection and preservation of blood specimens from patients with nonalcoholic fatty liver disease ( NAFLD) and the establishment and information management of biobank. Methods Whole blood samples were collected from 1226 patients who were diagnosed with NAFLD based on B...

Original articles_Biliary diseases

Experience in perioperative management in difficult laparoscopic cholecystectomy

Tang ShiLong, Li JunJiu, Zhang XiaoBing, Chen ZhanHui, Li DongWei, Ceng YongFeng

2014, 30(9): 910-912. DOI: 10.3969/j.issn.1001-5256.2014.09.018

Abstract(2011)

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Abstract:
Objective To investigate perioperative management and the prevention of complications in difficult laparoscopic cholecystectomy. Methods A retrospective analysis was performed on the clinical data of 82 patients, who underwent difficult laparoscopic cholecystectomy due to acute cholecystitis, Mirizz...

Original articles_Hepatopancreatobiliary tumor

Clinical effects of comprehensive treatment and liver transplantation for hepatocellular carcinoma exceeding Milan criteria: a comparative study

Liu JianYong, Cai QiuCheng, Jiang Yi

2014, 30(9): 913-916. DOI: 10.3969/j.issn.1001-5256.2014.09.019

Abstract(3258)

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Abstract:

Objective To analyze and compare the clinical effects of comprehensive treatment and liver transplantation for hepatocellular carcinomas ( HCC) exceeding Milan criteria. Methods A retrospective analysis was performed on the clinical data of 157 patients with HCC ( exceeding Milan criteria) who recei...

Efficacy of transcatheter arterial chemoembolization in patients with hepatocellular carcinoma before hepatectomy:a meta-analysis

Gao Sheng, Liu JianYong, Zhang ZhiMing, Zhao YinNong, Yuan WeiPing, Wu FeiXiang, Xiang BangDe

2014, 30(9): 917-920. DOI: 10.3969/j.issn.1001-5256.2014.09.020

Abstract(2654)

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Abstract:

Objective To assess the efficacy of transcatheter arterial chemoembolization ( TACE) in patients with hepatocellular carcinoma ( HCC) before hepatectomy. Methods PubMed, Embase, the Cochrane Library, CNKI, VIP, and Wanfang Data were searched to identify randomized controlled trials ( RCTs) evaluatin...

Correlation of GGT with AFP and diagnostic value of GGT for hepatocellular carcinoma

Gao Chun, Fang Long, Yao ShuKun

2014, 30(9): 921-925. DOI: 10.3969/j.issn.1001-5256.2014.09.021

Abstract(3289)

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Abstract:

Objective To analyze the correlation of gamma- glutamyl transpeptidase ( GGT) level with alpha- fetoprotein ( AFP) level and to re- evaluate the diagnostic value of GGT for hepatocellular carcinoma ( HCC) . Methods Four hundred and seventy- two patients with HCC or liver cirrhosis, who were hospital...

Relationship between classification of Doppler ultrasound blood flow signals and angiogenesis in primary hepatocellular carcinoma

Ma YanYan, Liu Ying, Zhang JingZhuo

2014, 30(9): 926-928. DOI: 10.3969/j.issn.1001-5256.2014.09.022

Abstract(2695)

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Abstract:

Objective To investigate the relationship of the classification of Doppler ultrasound blood flow signals with matrix metalloproteinase- 9 ( MMP- 9) expression and microvessel density ( MVD) in primary hepatocellular carcinoma ( PHC) . Methods Sixty patients with PHC, who underwent surgical resection...

Brief reports

Dynamic changes in B7- H1 expression on peripheral blood mononuclear cells in chronic hepatitis B patients treated with entecavir

Wu LieXiu, Lin ShuMei, Zhang Xi, Zheng ShuQin, Ye Feng, Chen TianYan, Zhao YingRen, Zhang ShuLin

2014, 30(9): 929-931. DOI: 10.3969/j.issn.1001-5256.2014.09.023

Abstract(1825)

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Case reports

Abernethy malformation misdiagnosed as liver cirrhosis: a report of one case

Li Li, Gou ChunYan, Li JingYing, Li XiuHui

2014, 30(9): 932-934. DOI: 10.3969/j.issn.1001-5256.2014.09.024

Abstract(302)

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Abstract:

Reviews

Research progress in TIM-3 and HBV infection

Dong Jie, Shen HuanJun, Yang XiaoFei, Zhao RongRong, Zhang Ye, Zhao YanYan, Huang ZhangXing, Lian JianQi

2014, 30(9): 935-938. DOI: 10.3969/j.issn.1001-5256.2014.09.025

Abstract(229)

PDF (732KB)(167)

Abstract:
Studies have found that T cell Ig- and mucin- domain- containing molecule- 3 ( TIM- 3) is associated with the development of many diseases. In hepatitis B virus ( HBV) infection, TIM- 3 acts as a negative immune regulatory molecule and its expression on CD8+T cells increases markedly. It indicates t...

Research advances in role of myeloid- derived suppressor cells in tumorigenesis

Ji Bo, Liu YaHui

2014, 30(9): 939-943. DOI: 10.3969/j.issn.1001-5256.2014.09.026

Abstract(2805)

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Abstract:
The role of myeloid- derived suppressor cells ( MDSCs) in promoting inflammatory response and immune escape of tumor cells and the mechanism by which MDSCs promote the development and progression of tumors are reviewed. This could provide a new way for the investigation of immunological mechanism of...

Current status and progress in research on helicobacter infection and chronic liver diseases

Chi ZhaoChun

2014, 30(9): 944-947. DOI: 10.3969/j.issn.1001-5256.2014.09.027

Abstract(2726)

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Abstract:
There has been increasing research on the association between Helicobacter infection and liver diseases, mostly the influence of Helicobacter on liver diseases. The prevalence and bacteriology of Helicobacter during the development of liver diseases, the mechanism by which Helicobacter causes liver ...

Research advances in animal models of nonalcoholic fatty liver disease

Huang HaiYan, Xin YongNing, Jiang Man, Jin WenWen, Jiang XiangJun, Xuan ShiYing

2014, 30(9): 948-953. DOI: 10.3969/j.issn.1001-5256.2014.09.028

Abstract(3128)

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Abstract:
In recent years, the incidence of nonalcoholic fatty liver disease ( NAFLD) has increased gradually along with the rising prevalence of obesity, type 2 diabetes, and hyperlipidemia, and NAFLD has become one of the most common chronic liver diseases in the world and the second major liver disease aft...

Role of PI3K /Akt /mTOR signaling pathway in hepatocellular carcinoma

Yu Yuan, Chen XiaoRong

2014, 30(9): 954-957. DOI: 10.3969/j.issn.1001-5256.2014.09.029

Abstract(3218)

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Abstract:
Phosphatidylinositol 3- kinase, Akt, and the mammalian target of rapamycin ( PI3K/Akt/mTOR) signaling pathway is shown to play a key role in the tumorigenesis, proliferation, metastasis, apoptosis, and angiogenesis of hepatocellular carcinoma ( HCC) by regulating gene expression. The components and ...

Application of proteomics in study of hepatocellular carcinoma

Wang JianGang, Fei XinYing, Song Qing

2014, 30(9): 958-960. DOI: 10.3969/j.issn.1001-5256.2014.09.030

Abstract(2721)

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Abstract:
Hepatocellular carcinoma ( HCC) is one of the most fatal malignant tumors worldwide. As an important part of cutting- edge research fields, proteomics has been widely used in the studies of related diseases and has currently become a crucial experimental approach to research on HCC. Significantly ex...

Progress in evaluation and treatment of hepatic iron overload

Ding Rui, Jia JiDong

2014, 30(9): 961-964. DOI: 10.3969/j.issn.1001-5256.2014.09.031

Abstract(3974)

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Abstract:
Iron overload is a metabolic disorder characterized by excessive iron deposition in the liver, pancreas, heart, endocrine organs, etc., resulting in structural damage and dysfunction. The liver is the primary organ for iron storage, and excessive iron deposition induces liver inflammation and fibros...

Research advances in circulating miRNAs for diagnosis of hepatobiliary diseases

Peng XiaoFang, Liu HaiYing

2014, 30(9): 965-968. DOI: 10.3969/j.issn.1001-5256.2014.09.032

Abstract(2218)

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Abstract:
MicroRNAs ( miRNAs) are involved in the pathological and physiological process of life activities, and some of them exist stably and abundantly in serum, plasma, and other body fluids. Previous studies have indicated that there are significant differences in the expression patterns of circulating mi...