Clinical practice guidelines are defined as ‘‘systematically developed statements to assist practitioner and patient decisions about appropriate heath care for specific clinical circumstances.’’1 These guidelines on autoimmune hepatitis provide a data-supported approach to the diagnosis and management of this disease. They are based on the following: (1) formal review and analysis of the recently-published world literature on the topic [Medline search]; (2) American College of Physicians Manual for Assessing Health Practices and Designing Practice Guidelines; (3) guideline policies, including the AASLD Policy on the Development and Use of Practice Guidelines and the American Gastroenterological Association Policy Statement on Guidelines;3 and (4) the experience of the authors in the specified topic.