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Research progress in role of myosin light chain kinase in pathogenesis of nonalcoholic fatty liver disease
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摘要:
肌球蛋白轻链激酶（MLCK）是参与肠黏膜机械屏障功能的关键酶,在非酒精性脂肪性肝病（NAFLD）发病机制中发挥重要作用。介绍了影响NAFLD的"二次打击学说",肠道来源的内毒素在其发病机制中起着主要作用,叙述了内毒素、MLCK与NAFLD三者之间的联系,以及应用肌球蛋白轻链激酶抑制剂ML-7对肠道屏障的影响,应用ML-7可能对NAFLD的形成和进展起到抑制和延缓的作用,进而为早期预防NAFLD提供了新的临床思路。
Abstract:Myosin light chain kinase( MLCK) is a key enzyme involved in intestinal mucosal mechanical barrier and plays an important role in the pathogenesis of nonalcoholic fatty liver disease( NAFLD). This article describes the " two- hit theory" for NAFLD and gut- derived endotoxin which plays a major role in the pathogenesis of NAFLD,the relationship between endotoxin,MLCK,and NAFLD,and the impact of MLCK inhibitor ML- 7 on the intestinal barrier. MLCK inhibitor ML- 7 may hinder and delay the development and progression of NAFLD,providing a novel clinical idea for the early prevention of NAFLD.
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Key words:
- fatty liver /
- myosin-light-chain kinase /
- pathologic processes /
- review
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