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Role of Toll-like receptors in development and progression of nonalcoholic fatty liver disease
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摘要:
目前非酒精性脂肪性肝病(NAFLD)的发病尚不明确。有多项研究表明Toll样受体参与了NAFLD,特别是非酒精性脂肪性肝炎的发生和发展。简述了Toll样受体与炎症因素、Toll样受体与游离脂肪酸间的相互作用、Toll样受体基因多态性3个方面的进展,介绍了Toll样受体在NAFLD发病中的作用。
Abstract:The pathogenesis of nonalcoholic fatty liver disease( NAFLD) remains unclear. Many studies have shown that Toll- like receptors are involved in the development and progression of NAFLD,especially nonalcoholic steatohepatitis. This article reviews the role of Toll- like receptors in the pathogenesis of NAFLD from three aspects: interactions between Toll- like receptors and inflammatory factors,interactions between Toll- like receptors and free fatty acids,and Toll- like receptor gene polymorphism.
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Key words:
- fatty liver /
- Toll-like receptors /
- review
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