Fatty liver and light manual labor: an epidemiological survey in Tianjin by controlled attenuation parameter
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摘要:
目的了解天津市轻体力劳动者脂肪肝患病率及可能的相关因素。方法随机选取天津市某公司既往体健从事轻体力劳动者,共602例健康职工顺利进行查体及全部数据收集。应用Fibro Scan受控衰减参数(CAP)方法检测其脂肪含量及肝脏硬度,同时调查受检者病史、体质量、身高、血压及生活习惯等,分析不同程度脂肪肝的可能相关因素。组间计量资料采用Kruskal Wallis H秩和检验,计数资料采用行×列表χ2检验,两两比较采用χ2分割法进行,对CAP方法和彩超进行一致性检验采用Kappa分析。结果经调查,602例受检者中180(29.9%)例为重度脂肪肝;195(32.3%)例轻中度脂肪肝;227(37.7%)例无脂肪肝。按照本方法检测的结果分组,3组患者年龄、身体质量指数、腰臀比、吸烟、饮酒、糖尿病史及家族史等差异均有统计学意义(P值均<0.05)。且本检测方法灵敏性更高,检出脂肪肝比例高于传统的彩超检出比率(62.3%vs 44.0%,P=0.000),二者一致性较差(Kappa<0.4)。结论在从事轻体力劳动的"健康人群",脂肪肝的患病率已经超过60%,其与身体质量指数、腰臀比、不良...
Abstract:Objective To investigate the incidence and possible related factors for fatty liver among workers engaged in light manual labor in Tianjin,China. Methods Among 800 healthy workers engaged in light manual labor randomly selected from a company in Tianjin,a total of 602 healthy workers completed physical examination and data collection. The content of fat and liver stiffness were determined by controlled attenuation parameter( CAP) using Fibro Scan,and the disease history,body mass,height,blood pressure,and living habits in all subjects were investigated. The possible related factors for different degrees of fatty liver were analyzed. Between- group comparison of continuous data was performed using the Kruskal- Wallis H test,and comparison of categorical data was performed using χ2test with row × column tables. Pairwise comparison was performed using χ2segmentation method,and the agreement between CAP and color ultrasound was analyzed using the Kappa coefficient. Results Among the 602 subjects,there were 180( 29. 9%),195( 32. 3%),and 227( 37. 7%) subjects with severe fatty liver,moderate fatty liver,and no fatty liver,respectively. There were significant differences in age,body mass index,waist- hip ratio,smoking,drinking,history of diabetes,and family history between the above three groups according to CAP( P <0. 05 for all). With higher sensitivity,CAP achieved a significantly higher detection rate of fatty liver than traditional color ultrasound( 62. 3% vs 44. 0%,P = 0. 000). The agreement between two methods was poor( Kappa value < 0. 4). Conclusion Among the so-called“healthy people”engaged in light manual labor,the incidence of fatty liver has exceeded 60%,which is associated with body mass index,waist- hip ratio,bad living habits,history of diabetes,and family history of fatty liver. CAP can noninvasively detect fatty liver with higher sensitivity and less time; however,its clinical significance needs further studies.
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Key words:
- fatty liver /
- controlled attenuation parameters /
- prevalence /
- Tianjin
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