Role of gut microbiota regulation in traditional Chinese medicine treatment of non- alcoholic fatty liver disease
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摘要: 根据近年来研究发现肠道菌群在非酒精性脂肪性肝病(NAFLD)的发病机制中具有重要作用,系统阐述了在NAFLD与肠源性内毒素血症、短链脂肪酸、胆汁酸代谢、内源性乙醇的关系基础上,结合对中药调节肠道菌群与治疗NAFLD作用关系的研究进展,提出中药靶向调节肠道菌群,不仅是中医药临床治疗实践的现代诠释,更重要的是有可能成为NAFLD治疗的一种新策略。Abstract: Based on recent studies which have shown that gut microbiota plays an important role in the pathogenesis of non- alcoholic fatty liver disease( NAFLD),the article elaborates on the relationship of NAFLD with intestinal endotoxemia,short- chain fatty acids,bile acid metabolism,and endogenous ethanol. By illustrating the author's research progress in the relationship between traditional Chinese medicine( TCM) regulation of gut microbiota and NAFLD treatment,the article proposes that this approach is not only a clinical practice of TCM in the modern era,it may also become a new strategy in the treatment of NAFLD.
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Key words:
- fatty liver /
- enterobacteriaceae /
- Chinese medicine /
- therapy
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