线粒体功能障碍在肝纤维化发病中的作用机制

洪雨蝶; 郭锦晨; 施卫兵; 孙宇洁; 王佳敏; 高甜甜

doi:10.12449/JCH260124

线粒体功能障碍在肝纤维化发病中的作用机制

DOI: 10.12449/JCH260124

1.
安徽中医药大学第一附属医院肝病科，合肥 230031
2.
安徽中医药大学中医学院，合肥 230012

基金项目:

安徽省教育厅高等学校科学研究重点项目 (2023AH050733);

安徽省教育厅高等学校科学研究重点项目 (2023AH050783);

合肥综合性国家科学中心大健康研究院新安医学与中医药现代化研究所重点培育项目 (2023CXMMTCM009)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：洪雨蝶负责设计论文框架，撰写论文；郭锦晨负责拟定写作思路；施卫兵指导撰写文章并定稿；孙宇洁负责起草文章大纲；王佳敏负责整理机制图思路；高甜甜负责审阅文章。

详细信息

通信作者:
施卫兵，swbsxj@163.com （ORCID： 0009-0000-8547-136X）

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出版历程
- 收稿日期: 2025-05-21
- 录用日期: 2025-07-04
- 出版日期: 2026-01-25

Research advances in mitochondrial dysfunction in the pathogenesis of hepatic fibrosis

1.
Department of Hepatology，The First Affiliated Hospital School of Anhui University of Chinese Medicine，Hefei 230031，China
2.
College of Traditional Chinese Medicine，Anhui University of Chinese Medicine，Hefei 230012，China

Research funding:

Key Scientific Research Projects of Higher Education Institutions of Anhui Provincial Department of Education (2023AH050733);

Key Scientific Research Projects of Higher Education Institutions of Anhui Provincial Department of Education (2023AH050783);

Key Cultivation Project of Xin’an Medical and Traditional Chinese Medicine Modernization Research Institute of Hefei Comprehensive National Science Center Big Health Research Institute (2023CXMMTCM009)

More Information

Corresponding author: SHI Weibing， swbsxj@163.com （ORCID： 0009-0000-8547-136X）

摘要

摘要: 肝纤维化是在多种致病因素的影响下，肝内纤维结缔组织过度堆积并异常增生，可进展为肝硬化、门静脉高压及肝癌。其病理机制涉及肝细胞损伤、炎症细胞浸润与炎症介质释放、肝星状细胞活化以及细胞外基质堆积等。近年研究关注线粒体功能障碍在该疾病发展，包括代谢紊乱与能量不足、氧化应激、线粒体动态失衡、自噬功能改变等机制驱动肝纤维化的分子通路，这些均能引起肝损伤。本文综述了线粒体功能障碍在肝纤维化发病机制中的最新进展，可为临床治疗提供新治疗策略。
- 肝纤维化 /
- 线粒体 /
- 病理过程
Abstract: Hepatic fibrosis refers to excessive accumulation and abnormal proliferation of fibrous connective tissue in the liver triggered by multiple pathogenic factors， and it may progress to liver cirrhosis， portal hypertension， and liver cancer. The pathological mechanisms of hepatic fibrosis involve hepatocyte injury， inflammatory cell infiltration with the release of inflammatory mediators， hepatic stellate cell activation， and extracellular matrix deposition. Recent studies have focused on mitochondrial dysfunction in disease progression， including the molecular pathways for hepatic fibrosis driven by metabolic disorders， energy deficiency， oxidative stress， mitochondrial dynamic imbalance， and autophagic dysfunction， all of which can induce liver injury. This article reviews the latest advances in hepatic fibrosis， in order to provide new therapeutic strategies for clinical management.
- Hepatic Fibrosis /
- Mitochondria /
- Pathologic Processes

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注：线粒体功能障碍（如氧化磷酸化受损、ATP生成减少等）导致线粒体动力学异常（分裂增强、融合抑制），激活Bax、Drp1等蛋白，促使细胞色素c和mtDNA释放，触发凋亡体形成（如Apaf-1参与），并通过Fas/FasL、PINK1/Parkin等通路诱导细胞凋亡。同时，炎症小体激活、脂质堆积及PI3K/Akt通路异常进一步促进HSC活化与纤维化，形成炎症与凋亡相互加剧的恶性循环。

图 1 线粒体功能障碍影响肝纤维化的作用机制

Figure 1. Role of mitochondrial dysfunction affecting liver fibrosis

下载: 全尺寸图片幻灯片

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