线粒体动力学失衡在不同肝病中的作用

闵远骞; 李姗; 刘湘花; 杨艺; 禄保平

doi:10.12449/JCH250934

线粒体动力学失衡在不同肝病中的作用

DOI: 10.12449/JCH250934

闵远骞¹,
李姗²,
刘湘花³,
杨艺²,
禄保平^4, , ,

1.
河南中医药大学，第二临床医学院，郑州 450046
2.
河南中医药大学，医学院，郑州 450046
3.
河南中医药大学，中医药科学院，郑州 450046
4.
河南中医药大学，肝病研究所，郑州 450046

基金项目:

国家自然科学基金面上项目 (82474681);

河南省中医药科学研究专项 (2022ZY1167);

河南省高等学校青年骨干教师培养计划 (2021GGJS084);

河南省重点学科项目 (Teaching and Research［2023］414)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：闵远骞负责撰写论文及图片整理；李姗负责课题设计及修改论文；刘湘花、杨艺负责文献检索及整理；禄保平负责拟定写作思路及最后定稿。

详细信息

通信作者:
禄保平， lbp1921@sohu.com （ORCID： 0000-0002-3707-2185）

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出版历程
- 收稿日期: 2024-09-02
- 录用日期: 2024-09-28
- 出版日期: 2025-09-25

Role of mitochondrial division/fusion in different liver diseases

1.
The Second Clinical Medical School, Henan University of Chinese Medicine，Zhengzhou 450046，China
2.
School of Medicine, Henan University of Chinese Medicine，Zhengzhou 450046，China
3.
Academy of Chinese Medicine, Henan University of Chinese Medicine，Zhengzhou 450046，China
4.
Institute of Hepatology, Henan University of Chinese Medicine，Zhengzhou 450046，China

Research funding:

National Natural Science Foundation of China （General Program） (82474681);

The Special Research Project of Traditional Chinese Medicine in Henan Province (2022ZY1167);

The Training Program for Young Scholars in Universities of Henan Province (2021GGJS084);

Key Discipline Project of Henan Province (Teaching and Research［2023］414)

More Information

Corresponding author: LU Baoping， lbp1921@sohu.com （ORCID： 0000-0002-3707-2185）

摘要

摘要: 线粒体在肝细胞中含量丰富，在肝脏正常运转过程中发挥着重要作用。线粒体分裂/融合是维持线粒体动态平衡的两个生物过程，其还与细胞功能变化及疾病发生发展有密切联系，平衡线粒体分裂/融合在多种疾病的治疗中具有关键意义。近年来研究发现，异常的线粒体分裂/融合在脂肪肝、肝炎、肝纤维化和肝癌4个肝病发展阶段中作用显著，以调控这种异常为基础的治疗靶点不断被发现。本文通过对线粒体分裂/融合在肝病进程中不同阶段作用的综述，进一步展示了慢性肝病中线粒体分裂/融合机制的作用，也为更多以线粒体分裂/融合为基础，治疗、缓解甚至逆转肝病发展的思路提供科学依据。
- 线粒体 /
- 脂肪肝 /
- 肝纤维化 /
- 癌，肝细胞
Abstract: Mitochondria are abundant in hepatocytes and play an important role in the normal operation of the liver. Mitochondrial division/fusion is two biological processes that maintain the dynamic balance of mitochondria， and it is closely associated with the change of cell function and the development and progression of diseases. Balance of mitochondrial division/fusion is of key significance in the treatment of many diseases. Recent studies have shown that abnormal mitochondrial division/fusion plays a significant role in fatty liver disease， hepatitis， liver fibrosis， and liver cancer， which are the four stages of the progression of liver diseases， and the therapeutic targets based on the regulation of such abnormalities are constantly being identified. By reviewing the role of mitochondrial division/fusion in different stages of liver disease， this article further demonstrates the role of mitochondrial division/fusion mechanism in chronic liver diseases and also provides a scientific basis for more ideas on the treatment， remission or even reversal of liver disease progression based on mitochondrial division/fusion.
- Mitochondria /
- Fatty Liver /
- Hepatic Fibrosis /
- Carcinoma， Hepatocellular

HTML全文

图 1 线粒体分裂/融合机制变化

Figure 1. Changes in mitochondrial division/fusion mechanisms

下载: 全尺寸图片幻灯片

图 2 调控线粒体分裂/融合对慢性肝病不同阶段的影响

Figure 2. Regulating the effects of mitochondrial division/fusion on different stages of chronic liver disease

下载: 全尺寸图片幻灯片

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