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IRE1α/TRAF2/JNK信号通路在急性肝衰竭发展中的作用机制及潜在价值

关海梅 张衎 陈玮钰 李国宝 曾阳玲 张日云 王恬雯 谢宝华 毛德文

引用本文:
Citation:

IRE1α/TRAF2/JNK信号通路在急性肝衰竭发展中的作用机制及潜在价值

DOI: 10.12449/JCH240633
基金项目: 

国家自然科学基金 (82274434);

国家自然科学基金 (81960841);

国家自然科学基金 (82060848);

广西中医药大学研究生教育创新计划 (YCBZ2023157)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:关海梅负责拟定写作思路并撰写文章;陈玮钰、曾阳玲负责设计论文框架;李国宝、张日云负责收集、整理相关文献;王恬雯、谢宝华负责修订论文;毛德文、张衎提供指导意见并最后定稿。
详细信息
    通信作者:

    毛德文, mdwboshi2005@163.com (ORCID: 0000-0001-9438-9325)

Mechanism of action and potential value of the IRE1α/TRAF2/JNK pathway in the progression of acute liver failure

Research funding: 

National Natural Science Foundation of China (82274434);

National Natural Science Foundation of China (81960841);

National Natural Science Foundation of China (82060848);

Guangxi University of Traditional Chinese Medicine Graduate Education Innovation Program (YCBZ2023157)

More Information
  • 摘要: 急性肝衰竭(ALF)是临床上最危重的一种肝脏疾病,严重影响我国人民生命健康。由于ALF的发病率和死亡率高、发病机制不明确、治疗手段有限,成为肝病领域亟待解决的重大难题。近年来,越来越多研究表明,内质网应激是ALF进展中一个关键的生物学过程,IRE1α/TRAF2/JNK通路作为内质网应激信号传导的一部分,在疾病的发展中发挥着放大炎症反应、促进肝细胞凋亡、抑制肝再生能力等作用。而中医药作为我国传统瑰宝,从中药单体中寻找有效防治ALF的药物成为研究热点。本文旨在通过阐述IRE1α/TRAF2/JNK通路在ALF发展中的作用机制,以及总结红景天苷、楮实子、补骨脂+五味子、黄芩素、京尼平、山柰酚、白藜芦醇、沙棘多糖提取物、木犀草素等中药单体调控该通路的潜在价值,以期为ALF的进一步研究和临床实践提供参考依据。

     

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  • 收稿日期:  2023-11-15
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