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中性粒细胞胞外诱捕网(NET)与肝脏疾病的关系

仁增卓嘎 杨康洁 芦永良 王志鑫 王海久

引用本文:
Citation:

中性粒细胞胞外诱捕网(NET)与肝脏疾病的关系

DOI: 10.12449/JCH240334
基金项目: 

青海省科技厅临床医学研究中心项目 (2017-SF-L2)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:仁增卓嘎负责课题设计,收集文献,撰写论文;杨康洁参与图片制作;王志鑫参与论文修改;芦永良、王海久等负责拟定写作思路,指导撰写文章并最后定稿。
详细信息
    通信作者:

    王海久, wanghaijiuqy@126.com (ORCID: 0000-0001-6033-238X)

Research advances in neutrophil extracellular traps and liver diseases

Research funding: 

Qinghai Provincial Department of Science and Technology Clinical Medical Research Center Project (2017-SF-L2)

More Information
  • 摘要: 中性粒细胞通过释放中性粒细胞弹性蛋白酶和髓过氧化物酶等蛋白酶,形成中性粒细胞胞外诱捕网(NET),在体内发挥免疫防御作用,并参与多种肝病的炎性反应,但其过度释放会加重肝组织损伤,成为肝脏疾病的危险因素之一。近年来,有研究发现NET的过度释放可促进病毒性肝炎、非酒精性脂肪性肝炎、肝脏缺血再灌注损伤等疾病向肝癌进展,阐明NET作用机制对肝脏疾病的诊断和进展过程具有重要意义。本文主要阐述NET在肝脏疾病中的最新研究进展,为肝脏疾病的诊疗和预防提供新的思路。

     

  • 图  1  NET形成与肝脏病理机制

    Figure  1.  NET formation and hepatic pathology

    图  2  NET与肝脏疾病的联系

    Figure  2.  The association of NET with liver disease

    表  1  影响肝缺血再灌注损伤的因素

    Table  1.   Factors that influence hepatic ischemia and reperfusion injury

    影响因素 机制 NET释放 参考文献
    增加因素
    HMGB1 刺激TLR4/TLR9 + 17
    丙烯醛 刺激NOX2和P38 MAPK + 22
    IL-17A 炎症风暴的中心驱动因子 + 18
    HRG 中性粒细胞浸润 + 19
    抑制因素
    二苯碘胺(DPI) NADPH氧化酶抑制剂 - 21
    苯甲酸酰肼 MPO氧化酶抑制剂 - 21
    西维来司 NE抑制剂 - 21
    阿司匹林、氯吡格雷 血小板活性抑制 - 21
    羟氯喹 抑制TLR9 - 16
    姜黄素 抑制MEK/ERK - 20
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  • 收稿日期:  2023-06-24
  • 录用日期:  2023-07-10
  • 出版日期:  2024-03-20
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