核因子E2相关因子2/血红素加氧酶-1(Nrf2/HO-1)信号通路在酒精性肝病中的作用

马成; 杨慧

doi:10.3969/j.issn.1001-5256.2023.07.028

核因子E2相关因子2/血红素加氧酶-1(Nrf2/HO-1)信号通路在酒精性肝病中的作用

DOI: 10.3969/j.issn.1001-5256.2023.07.028

马成¹,
杨慧^2, , ,

1.
山西医科大学研究生院，太原 030001
2.
山西医科大学第一医院感染病科，太原 030001

基金项目:

山西省省筹资金资助留学人员科研项目 (2020-168)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：马成负责收集文献，撰写论文；杨慧负责拟定写作思路，指导撰写文章，最后定稿及经费支持。

详细信息

通信作者:
杨慧，576371816@qq.com (ORCID：0000-0002-9162-6951)

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出版历程
- 收稿日期: 2022-09-20
- 录用日期: 2022-11-21
- 出版日期: 2023-07-20

Role of the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 signaling pathway in alcoholic liver disease

Cheng MA¹,
Hui YANG^{2
, ,
,}

1.
Graduate School of Shanxi Medical University, Taiyuan 030001, China
2.
Department of Infectious Diseases, The First Hospital of Shanxi Medical University, Taiyuan 030001, China

Research funding:

Scientific Research Project of Shanxi Province Raises Funds to Support Overseas Students (2020-168)

More Information

Corresponding author: YANG Hui, 576371816@qq.com (ORCID: 0000-0002-9162-6951)

摘要

摘要: 酒精性肝病(ALD)在我国的发病率逐年上升，国民的疾病负担日益增加。肝细胞的氧化应激反应是ALD的重要致病机制。核因子E2相关因子2/血红素加氧酶-1(Nrf2/HO-1)信号通路是人体重要的内源性抗氧化应激通路，在氧化应激作用下，Nrf2被激活并发挥其转录活性诱导HO-1高表达。HO-1是体内重要的氧化应激反应蛋白，与其血红素酶解产物(胆红素、CO、铁)共同发挥着抗炎、抗氧化及调控细胞凋亡的作用。本文将对近年来Nrf2/HO-1信号通路在ALD中的研究进展进行综述，力求为ALD的发生发展寻找理论依据及治疗切入点。
- 肝疾病, 酒精性 /
- NF-E2相关因子2 /
- 血红素加氧酶-1 /
- 信号传导
Abstract: The incidence rate of alcoholic liver disease (ALD) is increasing year by year China, and there is a gradual increase in disease burden among Chinese people. Oxidative stress response in hepatocytes is an important pathogenic mechanism of ALD. The nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway is an important endogenous anti-oxidative stress pathway in the body, and Nrf2 is activated in response to oxidative stress and exerts its transcriptional activity to induce high HO-1 expression. HO-1 is an important oxidative stress response protein and plays a role in anti-inflammation, anti- oxidation, and cell apoptosis regulation together with heme hydrolysis products (bilirubin, carbon monoxide, and iron). This article reviews the research advances in the role of the Nrf2/HO-1 signaling pathway in ALD in recent years, so as to find a theoretical basis for the development and progression of ALD and an entry point for treatment.
- Liver Diseases, Alcoholic /
- NF-E2-Related Factor 2 /
- Heme Oxygenase-1 /
- Signal Transduction

HTML全文

图 1 Nrf2和Keap1分子的结构域

注：a，Nrf2；b，Keap1。

Figure 1. The schematic diagram of Nrf2 and Keap1 domain structure

下载: 全尺寸图片幻灯片

图 2 Nrf2/HO-1信号通路的调控机制

Figure 2. The illustration of regulatory mechanisms for Nrf2/HO-1 signaling pathway

下载: 全尺寸图片幻灯片

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