JAK/STAT信号转导通路在肝纤维化形成中的作用

潘金; 琚坚

JAK/STAT信号转导通路在肝纤维化形成中的作用

潘金,
琚坚

昆明医科大学第二附属医院干疗消化科

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2013-05-20

Current perspectives on the JAK/STAT signaling pathway and its activating factors in liver fibrosis

Pan Jin,
Ju Jian

摘要

摘要:
JAK/STAT信号转导通路是一条由多种细胞因子和生长因子介导的信号转导通路,能参与细胞的增殖、分化、凋亡及炎症等病理生理过程。研究表明,JAK/STAT通路在肝纤维化的形成进程中具有重要的调控作用。本文就近年JAK/STAT信号转导通路在肝纤维化形成过程中的作用作一综述。
- Janus激酶类 /
- STAT转录因子类 /
- 信号传导 /
- 肝硬化
Abstract:
The Janus kinase (JAK) /signal transducer and activator of transcription (STAT) signaling pathway is an important signal transduction pathway activated by a variety of cytokines and growth factors and mediates various cellular processes involved in liver fibrosis, including proliferation, differentiation, apoptosis, and inflammation.In this article, the recent findings related to the function of JAK/STAT signaling and its activating factors in liver fibrosis are reviewed.Specifically, the roles of three cytokines leptin, interferon-alpha (IFN-α) and interleukin-4 (IL-4) are detailed in regards to their activation of the intracellular JAK/STAT pathway through the hepatic stellate cell membrane to promote expression of target genes involved in the fibrotic process.
- Janus kinases /
- STAT transcription factors /
- signal transduction /
- liver cirrhosis

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参考文献(28)

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