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肝组织炎症对FibroScan诊断慢性乙型肝炎患者肝纤维化的影响

刘志权 冯军花 叶立红 孝奇 杜瑞清 戴二黑

引用本文:
Citation:

肝组织炎症对FibroScan诊断慢性乙型肝炎患者肝纤维化的影响

基金项目: 

河北省卫生厅科研指令性课题(08189); 

详细信息
  • 中图分类号: R512.62

Effects of liver inflammation on FibroScan diagnosis of hepatic fibrosis in patients with chronic hepatitis B

Research funding: 

 

  • 摘要:

    目的探讨肝组织学炎症对瞬时弹性扫描仪(FS)诊断慢性乙型肝炎患者肝纤维化的影响。方法应用FS对124名慢性乙型肝炎患者进行肝穿刺前肝脏弹性测量值(LSM)的测定,采用肝穿刺活组织病理诊断技术进行肝纤维化分期(S)和炎症分级(G)。对同一肝纤维化分期不同肝组织炎症分级组间LSM进行比较,并对各肝纤维化分期中LSM与肝组织炎症分级进行相关性分析。结果肝组织纤维化逐渐发展伴随肝炎症程度加重,如肝纤维化S1期患者中以G1为主(81.8%),S2期以G2为主(54.2%),S3期以G3为主(47.4%),S4期以G3、G4为主(40%,33.4%),S1~S4每一纤维化分期水平上,不同炎症分级LSM差异均具有统计学意义(P<0.05),且LSM与不同炎症分级之间均呈显著正相关(P<0.01)。结论肝组织炎症程度是影响FS诊断的一个重要因素,炎症活动程度加重可使LSM增加。

     

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  • 出版日期:  2013-05-20
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