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microRNA、细胞自噬与肝纤维化

郭津生

引用本文:
Citation:

microRNA、细胞自噬与肝纤维化

基金项目: 

上海市浦江人才计划(09PJ1402600); 国家自然科学基金(3570825,81070340,91129705); 

详细信息
  • 中图分类号: R575.2

Recent perspectives on mechanisms of liver fibrogenesis: microRNA and cell autophagy 

Research funding: 

 

  • 摘要:

    近年来研究发现微小RNA(microRNA)在肝纤维化发生中起到重要调节作用,明晰miR表达谱的差别有助于揭示肝纤维化发生的分子调节机制、发现肝纤维化诊断的分子标志、并有助于发现新的治疗策略。此外研究还发现自噬(autophagy)信号在肝星状细胞(HSC)激活中起到重要作用,静息HSC通过自噬使含维生素A酯的脂滴释放和被利用,以此产生能量来驱动HSC的活化过程。该发现是肝纤维化发生机制的重要补充。

     

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  • 出版日期:  2013-05-20
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