环氧合酶-2与非酒精性脂肪性肝炎关系的研究进展

王亮; 张岭漪

环氧合酶-2与非酒精性脂肪性肝炎关系的研究进展

王亮,
张岭漪

兰州大学第二医院肝病科甘肃省消化肿瘤重点实验室

基金项目:

甘肃省科学事业费科技项目(QS012-C33-41)；兰州大学第二医院院内基金(YJ2010-09)；

详细信息

中图分类号: R575.1
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出版历程
- 出版日期: 2012-08-20

Cyclooxygenase-2 and nonalcoholic steatohepatitis

Research funding:

摘要

摘要: 非酒精性脂肪性肝炎（NASH）呈慢性肝脏脂毒性炎症表现,是非酒精性脂肪性肝病（NAFLD）的重要转折点,存在肝病重症化趋势。环氧合酶-2（COX-2）作为启动炎症反应的关键酶同样涉及到NASH的形成及进展。本文就COX-2及其抑制剂与NASH关系的研究予以综述。
- 环氧化酶-2 /
- 脂肪肝
Abstract: Nonalcoholic steatohepatitis (NASH) is characterized by chronic states of fatty liver infiltration and lipotoxic inflammation.NASH is considered a critical process for the progression of non-alcoholic fatty liver disease (NAFLD) to the severe stage.Cyclooxygenase-2 (COX-2) , a key pro-inflammatory factor, has been implicated in NASH pathogenesis.In this review, we discuss the recent findings concerning both the role of COX-2 in NASH and the potential therapeutic promise of COX-2 inhibitors.
- cyclooxygenase 2 /
- fatty liver

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参考文献(23)

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