Abstract: Objective To study the prognostic value of indocyanine green (ICG) R15 and other index of liver function in liver failure patients.Methods 32 patients with liver failure were analyzed for the ICG levels 15 minutes after injection (ICG R15) using pulse dye densitometry (PDD) at the time of admission and measured the level of index of liver function, such as Alb, CHE, PTA and CHO.Meanwhile MELD score was calculated.We also selected 15 cases of patients with chronic hepatitis, 94 cases of liver cirrhosis as control groups, and checked the ICG R15, Alb, CHE, PTA and CHO at the time of admission.We observed and followed up those patients with liver failure for 3 months.In the liver failure group we evaluated the prognostic value of ICG R15, MELD score by the receiver-operator-characteristic curve analysis (ROC curves analysis) .Results (1) The level of ICG R15, Alb, PTA, CHE and CHO In the chronic hepatitis group, liver cirrhosis group and liver failure group showed significant differences among the three groups (P<0.05) .Significant differences of ICG R15, Alb, CHE and PTA were observed between the chronic hepatitis group and liver cirrhosis group (P<0.05) ;and that of ICG R15, PTA, CHO were between the liver cirrhosis group and liver failure group (P<0.05) . (2) In liver failure group, ICG R15 in live group and death group were (50.05±9.04) % and (56.27±5.65) % in three months.The differences were statistically significant. (3) Area under the curve of MELD score was 60.4%%, and that of ICG R15 was 75.9%, which was better than MELD score.When ICG R15 was 52.5%, the sensitivity to predict death was 80% and specificity was 70.6%. (4) In liver failure group, there were 10 patients whose ICG R15 were less than 50%.2 of those 10 patients were dead within 3 months, the mortality was 20%.22 patients′ ICG R15 were more than 50%.14 of those 22 patients were dead within 3 months, the mortality was 63.6%.Conclusion (1) In the liver failure patients ICG R15 was g radually increased, and PTA was decreased.They were reflex severity of the disease. (2) By ROC curves analysis we found both of ICG R15 and MELD can make a prognosis in liver failure patients.Moreover the prognostic value of ICG R15 was better than that of MELD score. (3) The liver failure patients had a poor prognosis when their, ICG R15 were more than 50%.