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角蛋白18片段与炎症相关因子在脂肪性肝病诊断中的作用

李良平 钟黄

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角蛋白18片段与炎症相关因子在脂肪性肝病诊断中的作用

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  • 中图分类号: R575

The study of cytokeratin 18 fragments and inflammation related factors in non-alcoholic fatty liver disease

  • 摘要: 目的探讨非酒精性脂肪性肝病(NAFLD)伴代谢综合征(MS)的患者细胞角蛋白18片段、炎症相关因子的表达水平,为临床早期预防NAFLD伴有MS的患者向严重肝病进展提供依据。方法采用横断面调查研究,成组设计。入组85例脂肪肝患者及20例正常对照者。根据是否伴MS分为三组:NAFLD+MS组、NAFLD组、NC组。采用酶联免疫吸附法(ELISA)检测各组血清中细胞角蛋白18片段、炎症相关因子肿瘤坏死因子(TNF)α、白细胞介素6(IL-6)表达水平。通过速率散射比浊法检测血清超敏C-反应蛋白(hs-CRP)表达水平。结果 (1)血清细胞角蛋白18片段(M30)在NAFLD+MS组中高表达[(143±38.7)ng/L],与NAFLD组[(125±36.05)ng/L]、NC组[(118±30.40)ng/L]比较差异有统计学意义(P<0.05)。(2)炎症相关因子TNFα在NAFLD+MS组[(316±74.5)ng/L]和NAFLD组[(308.6±87.5)ng/L]升高、与NC组[(241.7±75.8)ng/L]比较差异有统计学意义(P<0.05),在NAFLD组与NA...

     

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  • 出版日期:  2012-05-20
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