CD4+CD25+调节性T细胞在自身免疫性肝炎发病机制中的作用

李艳丽; 赵艳; 闫惠平

CD4+CD25+调节性T细胞在自身免疫性肝炎发病机制中的作用

首都医科大学附属北京佑安医院自身免疫性肝病研究中心

基金项目:

北京市自然科学基金资助项目(7111004)；国家自然科学基金资助项目(81102265)；

详细信息

中图分类号: R575.1
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出版历程
- 出版日期: 2012-05-20

Evolution of regulatory T cells in pathogenesis of autoimmune hepatitis

Research funding:

摘要

摘要: <正>自身免疫性肝炎(autoimmune hepatitis,AIH)是一种免疫介导的、慢性肝脏炎症性疾病,以高γ球蛋白血症、自身抗体阳性、肝组织学界面炎和免疫抑制治疗有效为特征[1]。尽管AIH的发病机制尚未完全阐明,但多项证据表明,遗传易感性、分子模拟学说及调节性T细胞(regulatory T cells,Treg)缺陷参
- 自身免疫性肝炎 /
- 调节性T细胞 /
- 自身抗体
- autoimmune hepatitis /
- regulatory T cells /
- autoantibody

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参考文献(26)

[1]Liberal R, Longhi MS, Mieli-Vergani G, et al.Pathogenesisof autoimmune hepatitis[J].Best Pract Res Clin Gastroen-terol, 2011, 25 (6) :653-664.

[2]Sakaguchi S.Regulatory T cells:key controllers of immuno-logic self-tolerance[J].Cell, 2000, 101 (5) :455-458.

[3]Corthay A.How do regulatory T cells work?[J].Scand JImmunol, 2009, 70 (4) :326-336.

[4]Oo YH, Hubscher SG, Adams DH.Autoimmune hepatitis:new paradigms in the pathogenesis, diagnosis, and man-agement[J].Hepatol Int, 2010, 4 (2) :475-493.

[5]Sakaguchi S, Sakaguchi N, Asano M, et al.Immunologicself-tolerance maintained by activated T cell expressing IL-2 receptor alpha-chains (CD25) .Breakdown of a singlemechanism of self-tolerance cause various autoimmunedisease[J].J Immunol, 1995, 155 (3) :1151-1164.

[6]Sakaguchi S, Ono M, Setoguchi R, et al.Foxp3+CD4+CD25+natural regulatory T cells in dominant self-tolerance and auto-immune disease[J].Immunol Rev, 2006, 212:8-27.

[7]Carrier Y, Yuan J, Weiner H, et al.Th3 cells in peripheraltoleranee.Ⅱ.TGF-beta-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity[J].J Immunol, 2007, 178 (1) :172-178.

[8]Probst-Kepper M, Geffers R, Kroger A, et al.GARP:a keyreceptor controlling FOXP3 in human regulatory T cells[J].JCell Mol Med, 2009, 13 (9B) :3343-3357.

[9]Piccirillo CA, Shevach EM.Cutting edge:control of CD8+Tcell activation by CD4+CD25+immunoregulatory cells[J].JImmunol, 2001, 167 (3) :l137-1140.

[10]Allan SE, Crome SQ, Crellin NK et al.Activation-induced FOXP3in human T effector cells does not suppress proliferation or cyto-kine production[J].Int Immunol, 2007, 19 (4) :345-354.

[11]Liu W, Putnam AL, Xu-Yu Z, et al.CD127 expression inverselycorrelates with FoxP3 and suppressive function of human CD4+Treg cells[J].J Exp Med, 2006, 203 (7) :1701-1711.

[12]Seddiki N, Santner-Nanan B, Martinson J, et al.Expres-sion of interleukin (IL) -2 and IL-7 receptors discriminatesbetween human regulatory and activated T cells[J].J ExpMed, 2006, 203:1693-1700.

[13]Fontenot JD, Rasmussen JP, Williams LM, et al.RegulatoryT cell lineage specfication by the forkhead transcription factorfoxp3[J].Immunity, 2005, 22 (3) :329-341.

[14]Wang J, Ioan-Facsinay A, van der Voort EI, et al.Transi-ent expression of FOXP3 in human activated nonregulatoryCD4+T cells[J].Eur J Immunol, 2007, 37 (1) :129-138.

[15]Vergani D, Mieli-Vergani G.Aetiopathogenesis of autoim-mune hepatitis[J].World J Gastroenterol, 2008, 14 (21) :3306-3312.

[16]Longhi MS, Ma Y, Boqdanos DP, et al.Impairment of CD4 (+) CD25 (+) regulatory T-cells in autoimmune liver dis-ease[J].J Hepatol, 2004, 41 (1) :31-37.

[17]Longhi MS, Mitry RR, Samyn M, et al.Vigorous activation of mono-cytes in juvenile autoimmune liver disease escapes the control ofregulatory T-cells[J].Hepatology, 2009, 50 (1) :130-142.

[18]赵艳, 闫惠平, 檀玉芬, 等.抗可溶性肝抗原/肝胰抗原抗体在自身免疫性肝炎诊断及分型中的意义[J].中华肝脏病杂志, 2007, 15 (4) ;283-286.

[19]Zhao Y, Zhang YH, Liu YM, et al.Identification of T cellepitopes on soluble liver antigen in Chinese patients with au-toimmune hepatitis[J].Liver Int.2011, 31 (5) :721-729.

[20]Longhi MS, Meda F, Wang P, et al.Expansion and de novogeneration of potentially therapeutic regulatory T cells in pa-tients with autoimmune hepatitis[J].Hepatology, 2008, 47 (2) :581-591.

[21]Longhi MS, Hussain MJ, Kwok W, et al.Autoantigen-spe-cific regulatory T-cells, a potential tool for immune tolerancereconstitution in type-2 autoimmune hepatitis[J].Hepatol-ogy, 2011, 53 (2) :536-547.

[22]Apostolou I, Verginis P, Kretschmer K, et al.Peripherally in-duced Treg:mode, stability, and role in specific tolerance[J].J Clin Immunol, 2008, 28 (6) :619-624.

[23]Oo YH, Weston CJ, Lalor PF, et al.Distinct roles for CCR4and CXCR3 in the recruitment and positioning of regulatory Tcells in the inflamed human liver[J].J Immunol, 2010, 184 (6) :2886-2898.

[24]Lennon GP, Bettini M, Burton AR, et al.T cell islet accumu-lation in type 1 diabetes is a tightly regulated, cell-autono-mous event[J].Immunity, 2009, 31 (4) :643-653.

[25]Riley JL, June CH, Blazar BR.Human T regulatory cell ther-apy:take a billion or so and call me in the morning[J].Im-munity, 2009, 30 (5) :656-665.

[26]Trzonkowski P, Bieniaszewska M, Juscinska J et al.Frist-in-men clinical results of the treatment of patients with graft versushost disease with human ex vivo expanded CD4+CD25+CD127-Tregulatory cells[J].Clin Immunol, 2009, 133 (1) :22-26.

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