自身免疫性肝病的病理学新进展

郎振为

自身免疫性肝病的病理学新进展

郎振为

首都医科大学附属北京佑安医院病理科

详细信息

中图分类号: R575
计量
- 文章访问数: 3049
- HTML全文浏览量: 24
- PDF下载量: 801
- 被引次数: 0
出版历程
- 出版日期: 2012-05-20

Pathological advances in autoimmune liver disease

Lang ZhenWei

摘要

摘要: <正>自身免疫性肝病是指由于机体免疫系统攻击自体肝组织引起的肝组织损伤和肝功能异常的一组免疫性疾病,包括有自身免疫性肝炎(AIH)、原发性胆汁性肝硬化(PBC)和原发性硬化性胆管炎(PSC)。通常情况下这三种肝脏疾病独立存在,约有6%～9%的患者可以在同一时段或病程中出现两种疾病的临床表现、血清学和组织学特征,称为重叠综合征。近年来随
- 肝炎,自身免疫性 /
- 肝硬化,胆汁性 /
- 胆管炎,硬化性 /
- 病理学
- hepatitis /
- autoimmune /
- liver cirrhosis /
- biliary

HTML全文

参考文献(45)

[1]Czaja AJ, Bayraktar Y.Non-classical phenotypes of autoim-mune hepatitis and advances in diagnosis and treatment[J].World J Gastroenterol, 2009, 15 (19) :2314-2328.

[2]O’Brien C, Joshi S, Feld JJ, et al.Long-term follow-upof antimitochondrial antibody-positive autoimmune hepatitis[J].Hepatology, 2008, 48 (2) :550-556.

[3]Mehendiratta V, Mitroo P, Bombonati A, et al.Serologic mark-ers do not predict histologic severity or response to treatment inpatients with autoimmune hepatitis[J].Clin Gastroenterol Hep-atol, 2009, 7 (1) :98-103.

[4]Joshi M, Khettry U.Approach to diagrosis of auto-immunehepatitis[J].Indian J Pathol Micro, 2009, 52 (3) :293-303.

[5]Rubio CA.Detecting plasma cell precursors in autoimmunehepatitis[J].In Vivo, 2012, 26 (2) :319-322.

[6]Guindi M.Histology of autoimmune hepatitis and its variants[J].Clin Liver Dis, 2010, 14 (4) :577-590.

[7]Stravitz RT, Lefkowitch JH, Fontana RJ, et al.Autoimmuneacute liver failure:proposed clinical and histological criteria[J].Hepatology, 2011, 53 (2) :517-526.

[8]Fujiwara K, Fukuda Y, Yokosuka O.Precise histological eval-uation of liver biopsy specimen is indispensable for diagnosisand treatment of acute-onset autoimmune hepatitis[J].JGastroenterol, 2008, 43 (12) :951-958.

[9]Fujiwara K, Yasui S, Tawada A, et al.Autoimmune fulmi-nant liver failure in adults:Experience in a Japanese center[J].Hepatol Res, 2011, 41 (2) :133-141.

[10]Yasui S, Fujiwara K, Yonemitsu Y, et al.Clinicopathologicalfeatures of severe and fulminant forms of autoimmune hepa-titis[J].J Gastroenterol, 2011, 46 (3) :378-390.

[11]Fujiwara K, Yasui S, Yokosuka O.Efforts at making the di-agnosis of acute-onset autoimmune hepatitis[J].Hepatol-ogy, 2011, 54 (1) :371-372.

[12]Takahashi H, Zeniya M.Acute presentation of autoimmunehepatitis:Does it exist?A published work review[J].Hepa-tol Res, 2011, 41 (6) :498-504.

[13]Guido M, Burra P.De novo autoimmune hepatitis after livertransplantation[J].Semin Liver Dis, 2011, 31 (1) :71-81.

[14]Fiel MI, Agarwal K, Stanca C, et al.Posttransplant plasma cellhepatitis (de novo autoimmune hepatitis) is a variant of rejec-tion and may lead to a negative outcome in patients with hepati-tis C virus[J].Liver Transpl, 2008, 14 (6) :861-871.

[15]Zhang Y, Wang B, Wang T.De novo autoimmune hepatitiswith centrilobular necrosis following liver transplantation forprimary biliary cirrhosis:a case report[J].TransplantatProc, 2010, 42 (9) :3854-3857.

[16]Weiler-Normann C, Schrama C.Drug induced liver injuryand its relationship to autoimmune hepatitis[J].J Hepatol, 2011, 55 (4) :747-749.

[17]Sugimoto K, Ito T, Yamamoto N, et al.Seven cases of au-toimmune hepatitis that developed after drug-induced liverinjury[J].Hepatology, 2011, 54 (5) :1892-1893.

[18]Czaja AJ.Drug-induced autoimmune-like hepatitis[J].Dig Dis Sci, 2011, 56 (4) :958-976.

[19]Umemura T, Zen Y, Nakanuma Y, et al.Another cause of auto-immune hepatitis[J].Hepatology, 201l, 52 (1) :389-390.

[20]Chung H, Watanabe T, Kudo M, et al.Identification and char-acterization of IgG4-associated autoimmune hepatitis[J].LiverInternational, 2010, 30 (2) :222-231.

[21]Koyabu M, Uchida K, Miyoshi H, et al.Analysis of regulato-ry T cells and IgG4-positive plasma cells among patients ofIgG4-related sclerosing cholangitis and autoimmune liverdiseases[J].J Gastroenterol, 2010, 45 (7) :732-741.

[22]Umemura T, Zen Y, Hamano H, et al.Clinical significance ofimmunoglobulin G4-associated autoimmune hepatitis[J].JGastroenterol, 2011, 46 (Suppl 1) :48-55.

[23]European Association for the Study of the Liver.EASL Clini-cal Practice Guidelines:management of cholestatic liver dis-eases[J].J Hepatol, 2009, 51 (2) :237-267.

[24]Bioulac-Sage P.Primary biliary cirrhosis:A new histologicalstaging and grading system proposed by Japanese authors[J].Clin Res Hepatol Gastroenterol, 2011, 35 (5) :333-335.

[25]Nakanuma Y, Harada K.The role of the pathologist in diag-nosing and grading biliary diseases[J].Clin Res HepatolGastroenterol, 2011, 35 (5) :347-352.

[26]Poupon R.Primary biliary cirrhosis:A 2010 update[J].JHepatol, 2010, 52 (5) :745-758.

[27]Lindor KD, Gershwin ME, Poupon R, et al.Primary biliarycirrhosis[J].Hepatology, 2009, 50 (1) :291-308.

[28]Mendes F, Lindor KD.Antimitochondrial antibody–negativeprimary biliary cirrhosis[J].Gastroenterol Clin N Am, 2008, 37 (2) :479-484.

[29]European Association for the Study of the Liver.EASL Clini-cal Practice Guidelines:management of cholestatic liver dis-eases[J].J Hepatol, 2009, 51 (2) :237-267.

[30]Weyman RL, Voigt M.Consecutive occurrence of primary biliarycirrhosis and autoimmune hepatitis:a case report and review ofthe literature[J].Am J Gastroenterol, 2001, 96 (2) :585-587.

[31]Poupon R, Chazouilleres O, Corpechot C, et al.Developmentof autoimmune hepatitis in patients with typical primary biliarycirrhosis[J].Hepatology, 2006, 44 (1) :85-90.

[32]O’Brien C, Joshi S, Feld JJ, et al.Long-term follow-upof antimitochondrial antibody-positive autoimmune Hepatitis[J].Hepatology, 2008, 48 (2) :550-556.

[33]Nezu S, Tanaka A, Yasui H, et al.Presence of antimitochondri-al autoantibodies in patients with autoimmune hepatitis[J].JGastroenterol Hepatology, 2006, 21 (9) :1448-1454.

[34]Moreira RK, Revetta F, Koehler E, et al.Diagnostic utility ofIgG and IgM immunohistochemistry in autoimmune liver dis-ease[J].World J Gastroenterol, 2010, 16 (4) :453-457.

[35]Taylor SL, Haque S.Hepatobiliary pathology[J].Curr OpinGastroenterol, 2011, 27 (3) :248-255.

[36]周兴刚, 沈冰, 腾晓英, 等.免疫组化法检测原发性胆汁性肝硬化和自身免疫性肝炎肝组织中浆细胞IgM和IgG的意义探讨[J].中华内科杂志, 2010, 49 (12) :1043-1044.

[37]Singal AK, Stanca CM, Clark V, et al.Natural history of smallduct primary sclerosing cholangitis:a case series with review ofthe literature[J].Hepatol Int, 2011, 5 (3) :808-813.

[38]Bj rnsson E, Olsson R, Bergquist A, et al.The natural his-tory of small-duct primary sclerosing cholangitis[J].Gas-troenterology, 2008, 134 (4) :975-980.

[39]Webster GJM, Pereira SP, Chapman RW.Autoimmune pan-creatitis/IgG4-associated cholangitis-overlapping or sepa-rate diseases[J].J Hepatology, 2009, 51 (2) :398-402.

[40]Zhang L, Lewis JT, Abraham SC, et al.IgG4+plasma cellinfiltrates in liver explants with primary sclerosing cholangitis[J].Am J Surg Pathol, 2010, 34 (1) :88-94.

[41]Umemura T, Zen Y, Hamano H, et al.Immunoglobulin G4-hepatopathy:association of immunoglobulin G4-bearingplasma cells in liver with autoimmune pancreatitis[J].Hepa-tology, 2007, 46 (2) :463-471.

[42]Deshpande V, Sainani NI, Chung RT, et al.IgG4-associat-ed cholangitis:a comparative histological and immunopheno-typic study with primary sclerosing cholangitis on liver biopsymaterial[J].Mod Pathol, 2009, 22 (10) :1287-1295.

[43]Naitoh I, Zen Y, Nakazawa T, et al.Small bile duct involve-ment in IgG4-related sclerosing cholangitis:liver biopsy andcholangiography correlation[J].J Gastroenterol, 2011, 46 (2) :269-276.

[44]Koyabu M, Uchida K, Fukata N, et al.Primary sclerosingcholangitis with elevated serum IgG4 levels and/or infiltrationof abundant IgG4-positive plasma cells[J].J Gastroen-terol, 2010, 45 (1) :122-129.

[45]Bjornsson E, Chari S, Silveira M, et al.Primary sclerosingcholangitis associated with elevated immunoglobulinG4:clini-cal characteristics and response to therapy[J].Am J Thera-peutics, 2011, 18 (3) :198-205.

施引文献

资源附件(0)

访问统计