终末期肝病模型对肝硬化患者预后评估价值的研究进展

李晶莹; 陆伦根

终末期肝病模型对肝硬化患者预后评估价值的研究进展

上海交通大学医学院附属第一人民医院消化内科

详细信息

中图分类号: R575.2
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出版历程
- 出版日期: 2011-07-20

Progress of model for end-stage liver disease in the value of prognostic evaluation in patients with cirrhosis

摘要

摘要: 客观、准确地判断肝硬化患者的病情及预后有助于指导临床医生选择正确的治疗方案。终末期肝病模型(MELD)是目前被广泛认可的评估终末期肝病严重程度的评分体系。近年来各种基于MELD评分发展而来的新评分系统不断涌现。加入新的变量例如血清钠可进一步提高MELD的预测能力,此文就MELD的研究现状作一综述。
- 肝硬化 /
- 终末期肝病模型 /
- 预后
Abstract: An accurate, objective scoring system for severity and prognosis of liver disease is highly important for clinical management of patients with cirrhosis.The model for end-stage liver disease (MELD) score is a prospectively developed and validated scale for the severity of end-stage liver disease.Some new MELD-based prognostic models have been proposed in recent years.Incorporation of additional parameters, such as serum sodium level may further improve its prognostic accuracy.This article reviews the research state of prognostic models of end-stage liver disease.
- liver cirrhosis /
- model for end-stage liver disease /
- prognosis

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参考文献(31)

[1]Malinchoc M, Kamath PS, Gordon FD, et al.A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts[J].Hepatology, 2000, 31 (4) :864-871.

[2]Kamath PS, Wiesner RH, Malinchoc M, et al.A model to predict survival in patients with end-stage liver disease[J].Hepatology, 2001, 33 (2) :464-470.

[3]孙丽华, 徐琴, 肖琳, 等.两种人工肝支持系统治疗重型肝炎143例[J].中国组织工程研究与临床康复, 2010, 14 (25) :4697-4700.

[4]Robert A, Chazouilleres O.Prothrombin time in liver failure:time, ratio, activity percentage, or international normalized ratio?[J].Hepatology, 1996, 24 (6) :l392-1394.

[5]Gotthardt D, Weiss KH, Baumg?rtner M, et al.Limitations of the MELD score in predicting mortality or need for removal from waiting list in patients awaiting liver transplantation[J].BMC Gastroenterol, 2009, 9:72.

[6]Kamath PS, Kim WR.Is the change in MELD score a better indicator of mortality than baseline MELD score?[J].Liver Transplant, 2003, 9 (1) :19-21.

[7]Huo TI, Wu JC, Lin HC, et al.Evaluation of the increase in model for end-stage liver disease (Delta MELD) score over time as a prognostic predictor in patients with advanced cirrhosis:risk factor analysis and comparison with initial MELD and Child-Turcotte-Pugh score[J].J Hepatol, 2005, 42 (6) :826-832.

[8]Gines P, Guevara M.Hyponatremia in cirrhosis:pathogenesis, clinical significance and management[J].Hepatology, 2008, 48 (3) :1002-1010.

[9]Biggins SW, Rodriguez HJ, Bacehetti P.Serum sodium predicts mortality in patients listed for liver transplantation[J].Hepatology, 2005, 41 (1) :32-39.

[10]Biggins SW, Kim WR, Terrauh NA, et al.Evidence-based incorporation of serum sodium concentration into MELD[J].Gastroenterology, 2006, 130 (6) :1652-1660.

[11]陈湖岸, 陈颖华, 赵辉, 等.改良终末期肝脏疾病模型对慢性乙型重型肝炎预后的评估[J].中华外科杂志, 2009, 47 (23) :1771-1774.

[12]Kim WR, Biggins SW, Kremers W, et al.Hyponatremia and mortality among patients on the liver-transplant waiting list[J].N Engl J Med, 2008, 359 (10) :1018-1026.

[13]Huo TI, Wang YW, Yang YY, et al.Model for end-stage liver disease score to serum sodium ratio index as a prognostic predictor and its correlation with portal pressure in patients with liver cirrhosis[J].Liver Int, 2007, 27 (4) :498-506.

[14]Lv XH, Liu HB, Wang Y, et al.Validation of model for end-stage liver disease score to serum sodium ratio index as a prognostic predictor in patients with cirrhosis[J].J Gastroenterol Hepatol, 2009, 24 (9) :1547-1553.

[15]Luca A, Angermayr B, Bertolini G, et al.An integrated MELD model including serum sodium and age improves the prediction of early mortality in patients with cirrhosis[J].Liver Transplant, 2007, 13 (8) :1174-1180.

[16]Huo TI, Lin HC, Huo SC, et al.Comparison of four model for end-stage liver disease based prognostic systems for cirrhosis[J].Liver Transplant, 2008, 14 (6) :837-844.

[17]Yun BC, Kim WR, Benson JT, et al.Impact of pretransplant hyponatremia on outcome following liver transplantation[J].Hepatology, 2009, 49 (5) :1610-1615.

[18]Habib A, Mihas AA, Abou-Assi SG, et al.High-density lipoprotein cholesterol as an indicator of liver function and prognosis in noncholestatic cirrhotics[J].Clin Gastroenterol Hepatol, 2005, 3 (3) :286-291.

[19]Jiang M, Liu F, Xiong W J, et al.Combined MELD and blood lipid level in evaluating the prognosis of decompensated cirrhosis[J].World J Gastroenterol, 2010, 16 (11) :1397-1401.

[20]Ripoll C, Banares R, Rincon D, et al.Influence of hepatic venous pressure gradient on the prediction of survival of patients with cirrhosis in the MELD era[J].Hepatology, 2005, 42 (4) :793-801.

[21]Wang YW, Huo TI, Yang YY, et al.Correlation and comparison of the model for end-stage liver disease, portal pressure and serum sodium for outcome prediction in patients with liver cirrhosis[J].J Clin Gastroenterol, 2007, 4l (7) :706-712.

[22]Liu F, Cai LY, Chen C, et al.Model for end-stage liver disease combined with serum prealbumin to predict the prognosis of patients with decompenstated liver cirrhosis[J].J Dig Dis, 2010, 11 (6) :352-357.

[23]Kalabay L, Graf L, Voros K, et al.Human serum fetuin A/alpha2HS-glycoprotein level is associated with long-term survival in patients with alcoholic liver cirrhosis, comparison with the Child Pugh and MELD scores[J].BMC Gastroenterol, 2007, 7:15.

[24]Somsouk M, Guy J, Biggins SW, et al.Ascites improves upon serum sodium and MELD for predicting mortality in patients with advanced liver disease[J].Aliment Pharmaeol Ther, 2009, 30 (7) :741-748.

[25]Sharma P, Shaubel DE, Sima CS, et al.Re-weighting the model for end-stage liver disease score components[J].Gastroenterology, 2008, 135 (5) :1575-1581.

[26]Kim WR, Asrani SK, Benson JT, et al.'Re-weighted'MELD and serum sodium as predictors of liver transplant waitlist mortality[J].Am J Transplant, 2009, 9:348.

[27]Biselli M, Gitto S, Gramenzi A, et al.Six score systems to evaluate candidates with advanced cirrhosis for orthotopic liver transplant:which is the winner?[J].Liver Transplant, 2010, 16 (8) :964-973.

[28]Louvet A, Naveau S, Abdelnour M, et al.The Lille Model:a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids[J].Hepatology, 2007, 45 (6) :1348-1354.

[29]Gomez EV, Bertot LC, Oramas BG, et al.Application of a biochemical and clinical model to predict individual survival in patients with end-stage liver disease[J].World J Gastroenterol, 2009, 15 (22) :2768-2777.

[30]Francoz C, Prie D, AbdelRazek W, et al.Inaccuracies of creatinine and creatinine-based equations in candidates for liver transplantation with low creatinine:impact on the model for end-stage liver disease score[J].Liver Transplant, 2010, 16 (10) :1169-1177.

[31]Tripodi A, Chantarangkul V, Primignani M, et al.The international normalized ratio calibrated for cirrhosis (INR (liver) ) normalizes prothrombin time results for model for end-stage liver disease calculation[J].Hepatology, 2007, 46 (2) :520-527.

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