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婴儿胆汁淤积症145例临床分析

杨露 孙梅

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婴儿胆汁淤积症145例临床分析

详细信息
  • 中图分类号: R725.7

Clinical analysis of 145 cases with infantile cholestasis

  • 摘要: 目的对婴儿胆汁淤积症各个病因临床表现、辅助检查及预后进行统计学分析,归纳婴儿胆汁淤积症诊断及鉴别诊断方法。方法收集2007年12月~2010年2月本院住院的145例婴儿胆汁淤积症患儿的临床资料,对比胆道闭锁组与肝内胆汁淤积症组临床特点;分析巨细胞病毒(CMV)与胆汁淤积的关系;统计及评价胆道闭锁目前的临床诊断试验。结果胆道闭锁患儿白便及肝大发生率、GGT值及腹部彩超异常方面与婴儿肝内胆汁淤积症比较差异具有统计学意义。CMV感染与婴儿胆汁淤积相关性分析中,CMV阳性与阴性临床特征比较差异无统计学意义;胆道闭锁常用诊断项目中,白便的敏感度较高(88%),GGT>300 U/L、腹部彩超见三角形纤维包块特异度相对偏高。结论婴儿胆汁淤积症患儿有胆汁淤积症表现为生长发育正常,临床发现白便,腹部彩超提示汇管区三角形纤维包块,GGT>300 U/L时高度提示胆道闭锁;CMV感染在胆汁淤积症的发病中只是致病原因之一或者夹杂感染因素。

     

  • [1]Balistreri W, Ohi R, Todani T, et al.Hepatobiliary, pancreatic and splenic diseasein children:medicaland surgical management[M].Amsterdam:Elsevier, 1997:157-191.
    [2]Mieli-Vergani G, Howard ER, Mowat AP.Liver disease in infancy:a 20-year perspective[J].Gut, 1991, Suppl:S123-128.
    [3]Fischler B, Papadogiannakis N, Nemeth A.Aetiological factors in neonatal cholestasis[J].Acta Paediatr, 2001, 90 (1) :88-92.
    [4]Rafeey M, Golzar A, Javadzadeh A.Cholestatic syndromes of infancy[J].Pak J Biol Sci, 2008, 11 (13) :1764-1767.
    [5]Aanpreung P, Laohapansang M, Ruangtrakool R, et al.Neonatal cholestasis in Thai infant[J].J Med Assoc Thai, 2005, 88 (Suppl 8) :S9-15.
    [6]Moyer V, Freese DK, Whitington PF, et al.Guideline for the evaluation of cholestatic jaundice in infants:recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition[J].J Pediatr Gastroenterol Nutr, 2004, 39 (2) :115-128.
    [7]Hsiao CH, Chang MH, Chen HL, et al.Universal screening for biliary atresia using an infant stool color card in Taiwan[J].Hepatology, 2008, 47 (4) :1233-1240.
    [8]Bellomo-Brand?o MA, Porta G, Hessel G.Clinical and laboratory evaluation of 101 patients with intrahepatic neonatal cholestasis[J].Arq Gastroenterol, 2008, 45 (2) :152-155.
    [9]Bellomo-Brandao MA, Arnaut LT, Tommaso AM, et al.Differential diagnosis of neonatal cholestasis:clinical and laboratory parameters[J].J Pediatr (Rio J) , 2010, 86 (1) :40-44.
    [10]Dehghani SM, Haghighat M, Imanieh MH, et al.Comparison of different diagnostic methods in infants with Cholestasis[J].World J Gastroenterol, 2006, 12 (36) :5893-5896.
    [11]Imanieh MH, Dehghani SM, Bagheri MH, et al.Triangular cord sign in detection of biliary atresia:is it a valuable sign?[J].Dig Dis Sci, 2010, 55 (1) :172-175.
    [12]Mowat AP, Psacharopoulos HT, Williams R.Extrahepatic biliary atresia versus neonatal hepatitis.Review of 137 prospectively investigated infants[J].Arch Dis Child, 1976, 51 (10) :763-770.
    [13]Thaler MM, Gellis SS.Studies in neonatal hepatitis and biliary atresia:IV.Diagnosis[J].Am J Dis Child, 1968, 116 (3) :280-284.
    [14]Knight JA.Liver function tests:their role in the diagnosis of hepatobiliary diseases[J].J Infus Nurs, 2005, 28 (2) :108-117.
    [15]Wang JS, Wang ZL, Wang XH, et al.The prognostic value of serum gamma glutamyltransferase activity in Chinese infants with previously diagnosed idiopathic neonatal hepatitis[J].HK J Paediatics, 2008, 13 (1) :39.
    [16]Fischler B, Papadogiannakis N, Nemeth A.Clinical aspects on neonatal cholestasis based on observations at a Swedish tertiary referral centre[J].Acta Paediatr, 2001, 90 (2) :171-178.
    [17]VancíkováZ, KucerováT, Pelikán L, et al.Perinatal cytomegalovirus hepatitis:to treat or not to treat with ganciclovir[J].J Paediatr Child Health, 2004, 40 (8) :444-448.
    [18]Hung PY, Chen CC, Chen WJ, et al.Long-term prognosis of patients with biliary atresia:a 25 year summary[J].J Pediatr Gastroenterol Nutr, 2006, 42 (2) :190-195.
    [19]Lee WS, Chai PF, Boey CM, et al.Aetiology and outcome of neonatal cholestasis in Malaysia[M].Singapore Med J, 2010, 51 (5) :434-439.
    [20]Lee WS.Pre-admission consultation and late referral in infants with neonatal cholestasis[J].J Paediatr Child Health, 2008, 44 (1-2) :57-61.
    [21]Lee WS, Chai PF, Lim KS, et al.Outcome of biliary atresia in Malaysia:a single-centre study[J].J Paediatr Child Health, 2009, 45 (5) :279-285.
    [22]Farmer DG, Venick RS, McDiarmid SV, et al.Predictors of outcomes after pediatric liver transplantation:an analysis of more than 800 cases performed at a single institution[J].J Am Coll Surg, 2007, 204 (5) :904-914.
    [23]Muiesan P, Vergani D, Mieli-Vergani G.Liver transplantation in children[J].J Hepatol, 2007, 46 (2) :340-348.
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