Pediatric liver transplantation:present and future
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摘要: 儿童肝移植已经成为儿童终末期肝病的标准治疗方法。发展儿童肝移植意义重大。本文从适应证、生存率、手术方式、技术性并发症、免疫抑制治疗、远期生存状况和受体危险度分层等方面对目前儿童肝移植的发展水平进行初步概述,并对未来发展作初步展望。Abstract: Pediatric liver transplantation has become the standard therapy for end-stage liver diseases nowadays, and it is very important to develop the pediatric liver transplantation program.The aim of this article is to summarize the current status of pediatric liver transplantation in terms of indication, survival rate, graft type, technical complication, immunosuppressive therapy as well as long-term life quality, and to identify possible trends of future development.
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Key words:
- liver transplantation /
- liver diseases
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[1]McDiarmid SV, Anand R, Lindblad AS, et al.Studies of Pediatric Liver Transplantation:2002 update.An overview of demographics, indications, timing, and immunosuppressive practices in pediatric liver transplantation in the United States and Canada[J].Pediatr Transplant, 2004, 8 (3) :284-294. [2]Pimpalwar AP, Sharif K, Ramani P, et al.Strategy for hepatoblastoma management:transplant versus nontransplant surgery[J].J Pediatr Surg, 2002, 37 (2) :240-245. [3]Soltys KA, Mazameigos G, Squires RH, et al.Late graft loss or death in pediatric liver transplantation:an analysis of the SPLIT database[J].Am J Transplant, 2007, 7 (9) :2165-2171. [4]Diamond FC, Fecteau T, Millis J, et al.Impact of graft type on outcome after liver transplantation:a report From Studies of Pediatric liver transplantation (SPLIT) [J].Ann Surg, 2007, 246 (2) :301-310. [5]Jain A, Mazamegos G, Kashyap B, et al.Pediatric liver transplantation in 808 consecutive children:20-years experience from a single center[J].Transplant Proc, 2002, 34 (5) :1955-1957. [6]Busuttil R, Klintmailm G, Section VI.Split and living donor transplantation[M].Klintmalm G, Busuttil R.Transplantation of the Liver.Philadelphia:Elsevier Saunders, 2005:2. [7]Soubrane O, Cherqui D, Scatton O, et al.Laparoscopic left lateral sectionectomy in living donors:safety and reproducibility of the technique in a single center[J].Ann Surg, 2006, 244 (5) :815-820. [8]Yersiz H, Rense J, Farmer DG, et al.One hundred in situ split-liver transplantations:a singlecenter experience[J].Ann Surg, 2003, 238 (4) :496-505. [9]Adams D H, Neuberger J.Treatment of acute rejection[J].Semin Liver Dis, 1992, 12 (1) :80-88. [10]Ryckman FC, Schroeder T, Pedersen S, et al.Use of monoclonal antibody immunosuppressive therapy in pediatric renal and liver transplantation[J].Clin Transplant, 1991, 5 (3) :186-190. [11]Freese DK, Snover D, Sharp HL, et al.Chronic rejection after liver transplantation:a study of clinical, histopathological and immunological features[J].Hepatology, 1991, 13 (5) :882-891. [12]Koshiba T, Li Y, Takemura M, et al.Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation[J].Transpl Immunol, 2007, 17 (2) :94-97. [13]Berquist RK, Berquister W, Esquivel CO, et al.Adolescent non-adherence:prevalence and consequences in liver transplant recipients[J].Pediatr Transplant, 2006, 10 (3) :304-310. [14]Stuber ML, Shemesh E, Seacord D, et al.Evaluating non-adherence to immunosuppressant medications in pediatric liver transplant recipients[J].Pediatr Transplant, 2008, 12 (3) :284-288. [15]Miloh T, Arnon R.Improved adherence and outcomes for pediatric liver transplant recipients by using text messaging[J].Pediatrics, 2009, 124 (5) :844-850. [16]Lee V, Fecteau A, Shepherd R.Outcomes of 5-year survivors of pediatric liver transplantation:report on 461 children from a north american multicenter registry[J].Pediatrics, 2008, 122 (6) :1128-1135. [17]Scheenstra R, Peeters P, Verjade HJ, et al.Graft fibrosis after pediatric liver transplantatin:ten years of follow-up[J].Hepatology, 2009, 49 (3) :880-886. [18]Yaron A, Enza L, Mae C, et al.Health status ten years after pediatric liver transplantation-looking beyond the graft[J].Clin Transpl, 2004, 78 (4) :566-573. [19]Viner RM, Forton JTM, Cole TJ, et al.Growth of long term survivors of liver transplantation[J].Arch Dis Child, 1999, 80 (3) :235-240. [20]Gilmour S, Adkins R, Liddell GA, et al.Assessment of psych-oeducational outcomes after pediatric liver transplant[J].Am J Transpl, 2009, 9 (2) :294. [21]Taylor R, Franck L, Gibson F, et al.Study of the factors affecting health-related quality of life in adolescents after liver transplantation[J].Am J Transpl, 2009, 9 (5) :1179-1188.
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