中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

儿童及青少年非酒精性脂肪性肝病的确诊及危险因素评估

张一宁 杜红伟 刘彦军 王朝霞

引用本文:
Citation:

儿童及青少年非酒精性脂肪性肝病的确诊及危险因素评估

详细信息
  • 中图分类号: R575.5

The diagnosis and risk factors for evaluation of nonalcoholic fatty liver disease in children and adolescents

  • 摘要: 儿童和青少年时期非酒精性脂肪性肝病(NAFLD)是以肝细胞脂肪变性和脂肪蓄积为病理特征,而无饮酒史的临床综合征,它是代谢综合征和胰岛素抵抗在肝脏的表现,与儿童期的肥胖、性别、胰岛素抵抗和青春期具有相关性。因此,本病在儿童和青少年时期的诊断和评估要充分考虑不同于成人的许多高发风险因素,如性别、青春期的发育等因素。

     

  • [1]Moran JR, Gishan FK, Halter SA, et al.Steatohepatitis inobese children:a cause of chronic liver dysfunction[J].Am JGastroenterol, 1983, 78 (6) :374-377.
    [2]Schwimmer BJ, Deutsch R, Kahen T, et al.Prevalence of fattyliver in children and adolescents[J].Pediatrics, 2006, 118 (4) :1388-1393.
    [3]Park HS, Han JH, Choi KM, et al.Relation between elevatedserumalanine aminotransferase and metabolic syndrome in koreanadolescents[J].Am J Clin Nutr, 2005, 82 (5) :1046-1051.
    [4]Cortez-Pinto H, Camilo ME, Baptiste A, et al.Non-alcoholic fattyliver:another feature of metabolic syndrome?[J].Clin Nutr, 1999, 18 (6) :353-358.
    [5]Roberts EA.Nonalcoholic steatohepatitis in children[J].CurrGastroenterol Rep, 2003, 5 (3) :253-259.
    [6]Nobili V, Marcellini M, Devito R, et al.NAFLD in children:aprospective clinical-pathological study and effect of lifestyleadvice[J].Hepatology, 2006, 44 (2) :458-465.
    [7]Yoneda M, Iwasaki T, Fujita K, et al.Hypoadiponectinemia plays acrucial role in the development of nonalcoholic fatty liver diseasein patients with type 2 diabetes mellitus independent of visceraladipose tissue[J].Alcohol Clin Exp Res, 2007, 31 (Suppl 1) :15S-21S.
    [8]Schwimmer JB.Definitive diagnosis and assessment of risk for nonalcoholic fatty liver disease in children and adolescents[J].Semin Liver Dis, 2007, 27 (3) :312-318.
    [9]Kinugasa A, Tsunamoto K, Furukawa N, et al.Fatty liver and itsfibrous changes found in simple obesity of children[J].J PediatrGastroenterol Nutr, 1984, 3 (3) :408-414.
    [10]Baldridge AD, Perez-Atayde AR, Graeme-Cook F, et al.Idiopathicsteatohepatitis in childhood:a multicenter retrospective study[J].JPediatr, 1995, 127 (5) :700-704.
    [11]Schwimmer JB, Deutsch R, Rauch JB, et al.Obesity, insulinresistance, and other clinicopathogical correlations of pediatricnonalcoholic fatty liver disease[J].J Pediatr, 2003, 143 (4) :500-505.
    [12]Chan DFY, Li AM, Chu WC, et al.Hepatic steatosis in obeseChinese children[J].Int J Obes Relat Metab Disord, 2004, 28 (10) :1257-1263.
    [13]Jeffrey B, Schwimmer MD, Perrie E, et al.Cardiovascular riskfactors and the metabolic syndrome in pediatric nonalcoholic fattyliver disease[J].Circulation, 2008, 118:277-283.
    [14]Marion AW, Baker AJ, Dhawan A.Fatty liver disease in children[J].Arch Dis Child, 2004, 89 (7) :648-652.
    [15]Fernandes MT, Ferraro AA, de Azevedo RA, et al.Metabolicdifferences between male and female adolescents with non-alcoholic fatty liver disease, as detected by ultrasound[J].ActaPfidiatrica, 2010, 99 (8) :1218-1223.
    [16]Fishbein MH, Mogree C, Gleason T, et al.Relationship of hepaticsteatosis to adipose tissue distribution in pediatric nonalcoholicfatty liver disease[J].J Pediatr Gastroerrterol Nutr, 2006, 42 (1) :83-88.
    [17]Goran MI, Gower BA.Longitudinal study on pubertal insulinresistance[J].Diabetes, 2001, 50 (11) :2444-2450.
    [18]Papandreou D, Rousso I, Mavromichalis I.Update on non-alcoholic fatty liver disease in children[J].Clin Nutr, 2007, 26 (4) :409-415.
    [19]Schwimmer JB, McGreal N, Deutsch R, et al.Infiuence of gender, race, and ethnicity on suspected fatty liver in obeseadolescents[J].Pediatrics, 2005, 115 (5) :e561-565.
    [20]Clark JM, Brancati FL, Diehl AM, et al.Nonalcoholic fatty liverdisease[J].Gastroenterology, 2002, 122:1649-1657.
    [21]Schwimmer JB, Khorram O, Chiu V, et al.Abnormal aminotransferase activity in women with polycysticovary syndrome[J].FertilSteril, 2005, 83 (2) :494-497.
    [22]Cerda C, Pérez-Ayuso RM, Riquelme A, et al.Nonalcoholic fattyliver disease in women with polycystic ovary syndrome[J].JHepatol, 2007, 47 (3) :412-417.
    [23]Muthusamy T, Dhevika S, Murugesan P, et al.Testosteronedeftciency impairs glucose oxidation through defective insulinand its receptor gene expression in target tissues of'adult malerats[J].Life Sci, 2007, 8 (7) :534-542.
    [24]Fain JN, Madan AK, Hiler ML, et al.Comparison of the release ofadipokines by adipose tissue, adipose tissue matrix, and adipocytesfrom visceral and subcutaneous abdominal adipose tissues of obesehumans[J].Endocrinology, 2004, 145 (5) :273-282.
    [25]Khashab MA, Liangpunsakul S, Chalasani N.Nonalcoholic fattyliver disease as a component of the metabolic syndrome[J].CurtGastroenterol Rep, 2008, 10 (1) :73-80.
    [26] 中华医学会肝脏病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊疗指南 (2010年修订版) [J].中华内科杂志, 2010, 49 (3) :275-278.
    [27]Wang CL, Liang L, Fu JF, et al.Effect of lifestyle intervention onnon-alcoholic fatty liver disease in chinese obese children[J].World J Gastroenterol, 2008, 14 (10) :1598-1602.
    [28]Vajro P, Fontanella A, Perna C, et al.Persistent hyperaminotransferasemia resolving after weight reduction in obesechildren[J].J Pediatr, 1994, 125 (2) :239-241.
  • 加载中
计量
  • 文章访问数:  2364
  • HTML全文浏览量:  29
  • PDF下载量:  696
  • 被引次数: 0
出版历程
  • 收稿日期:  2011-04-15
  • 出版日期:  2011-07-20
  • 分享
  • 用微信扫码二维码

    分享至好友和朋友圈

目录

    /

    返回文章
    返回