小儿乙型肝炎的流行病学及诊治进展

俞蕙

小儿乙型肝炎的流行病学及诊治进展

俞蕙

复旦大学附属儿科医院感染传染科

详细信息

中图分类号: R725.1
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出版历程
- 出版日期: 2011-07-20

Advances in epidemiology, diagnosis and treatment of hepatitis B in children

Yu Hui

摘要

摘要: 中国是乙型肝炎的高发区,HBV母婴传播是我国人群感染HBV的主要传播途径之一。婴儿或儿童感染HBV,约15%～25%将发展为慢性乙型肝炎病毒携带者,是肝硬化和肝细胞癌的主要原因之一。本文对儿童乙型肝炎的流行病学、诊断以及治疗方面的进展进行综述。
- 肝炎,乙型 /
- 肝炎病毒,乙型 /
- 肝炎疫苗,乙型 /
- 抗病毒药
Abstract: China is high incidence area of hepatitis B.HBV mother-to-child transmission is one of main transmission ways in our country.About 15% to 25% of infants or children infected with HBV, will develop into HBV carriers, which is the leading cause of liver cirrhosis and hepatocellular carcinoma.Advances in epidemiology, diagnosis and treatment of hepatitis B in children are reviewed in this paper.
- hepatitis B /
- hepatitis B virus /
- antiviral agents /
- hepatitis B vaccines

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参考文献(16)

[1] 中华医学会.慢性乙型肝炎防治指南[J].中华内科杂志, 2006, 45 (2) :162-170.

[2]朱启镕.乙肝病毒母婴传播产前阻断的研究进展[J].中华妇幼医学杂志 (电子版) , 2006, 2 (1) :48-49.

[3]Chan CY, Lee SD, Lo KJ.Legend of hepatitis B vaccination:theTaiwan experience[J].J Gastroenterol Hepatol, 2004, 19 (2) :121-126.

[4]Chien YC, Jan CF, Kuo HS, et al.Nationalwide hepatitis Bvaccination program in Taiwan:effectiveness in the 20 years after itwas launched[J].Epidemiol Rev, 2006, 28:126-135.

[5]Liang SF, Bi SL, Yang WZ, et al.Epidemiological serosurvery ofHepatitis B in China-Decling HBV prevalence due to Hepatitis Bvaccination[J].Vaccine, 2009, 27 (47) :6550-6557.

[6]Fattovich G.Natural history of hepatitis B[J].J Hepatol, 2003, 39:S50-S58.

[7]Yim HJ, Lok AS.Natural history of chronic hepatitis B virusinfection:what we knew in 1981 and what we know in 2005[J].Hepatology, 2006, 43 (2 Suppl 1) :S173-181.

[8]张鸿飞, 朱世殊, 杨晓晋, 等.小儿乙、丙型肝炎临床与病理研究[J].传染病信息, 2006, 19 (3) :130-131.

[9]陈慧, 朱启镕, 王建设.免疫预防后经胎盘传递的乙型肝炎病毒标志及动态观察[J].中华传染病杂志, 2004, 22 (5) :335-336.

[10]Hongthanakorn C, Lok AS.New pharmacologic therapies in chronic hepatitis B[J].Gastroenterol Clin North Am, 2010, 39 (3) :659-680.

[11]Jonas MM, Kelly D, Pollack H, et al.Safety, efficacy, andpharmacokinetics of adefovir dipivoxil in children and adolescents (age 2 to<18 years) with chronic hepatitis B[J].Hepatology, 2008, 47 (6) :1863-1871.

[12]张鸿飞.儿童慢性乙型肝炎抗病毒治疗的时机与方案选择[J].中国实用儿科杂志, 2010, 25 (12) :903-905.

[13]王建设.儿童慢性乙型肝炎抗病毒治疗新进展[J].中华临床感染病杂志, 2010, 3 (1) :57-60.

[14]俞蕙.儿童慢性乙型肝炎的干扰素-α治疗[J].中国实用儿科杂志, 2010, 25 (12) :907-909.

[15]Jonas MM, Mizerski J, Badia IB, et al.Clinical trial of lamivudine inchildren with chronic hepatitis B[J].N Engl J Med, 2002, 346 (22) :1706-1713.

[16]Sokal E, Kelly D, Mizerski J, et al.Long-term lamivudine therapyfor children with HBeAg-positive chronic hepatitis B[J].Hepatology, 2006, 43 (2) :225-232.

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