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The effect of S-adenosyl-methionine treatment on drug-induced liver injury
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摘要: 目的评价不同剂量S-腺苷蛋氨酸治疗胆汁淤积型和混合型药物性肝损害的疗效和安全性。方法 66例胆汁淤积型和混合型药物性肝损害患者,分为对照组、治疗1组和治疗2组,每组22例,对照组给予常规基础保肝治疗外加用熊去氧胆酸和茵栀黄颗粒,治疗组除上述治疗外,同时加以S-腺苷蛋氨酸治疗。治疗1组应用S-腺苷蛋氨酸1g,1次/d,连续治疗4周;治疗2组以S-腺苷蛋氨酸2g,1次/d,连续治疗4周。监测各项肝功能指标。结果与对照组相比,治疗组总胆红素（TBil）、丙氨酸氨基转移酶（ALT）明显下降,差异有统计学意义（P<0.05）。治疗2组疗效在降低TBil、ALT方面明显优于治疗1组,差异有统计学意义（P<0.01）。结论胆汁淤积型和混合型药物性肝损害,给予S-腺苷蛋氨酸较常规保肝治疗效果明显,无不良反应,且大剂量疗效更为显著。Abstract: Objective To evaluate the therapeutic efficacy and safety of different dose S-adenosyl-L-methionine on drug-induced cholestasis liver injury and mixed liver injury.Methods a total of 66 patients suffered from drug-induced cholestasis liver injury and mixed liver injury were randomly divided into treatment group and control group.Furthermore, the treatment group was divided into 2 groups as treatment 1 group and treatment 2 group.The control group was treated with common therapy, while the treatment 1 group was treated with S-adenosyl-L-methionin up to 1 g/d as well as the treatment 2 group was treated with S-adenosyl-methionin up to 2 g/d.After 4 weeks of treatment, liver function was measured.Results The level of total bilirubin and alanine transaminase significantly decreased in the treatment group than the control group (P < 0.05) .Moreover, no adverse reactions were observed.Total bilirubin and alanine transarninase significantly decreased in treatment 2 group compared to treatment 1 group (P < 0.01) .Conclusion The therapeutic efficacy and safety of large dose S-adenosyl-L-methionin in treating drug-induced cholestasis liver injury and mixed liver injury is better compared to the common therapy.
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Key words:
- S-adenosyl-methionine /
- hepatitis
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