Abstract: Objective Observes the adefovir dipivoxil to press the liver cell growth hormone treatment chronic Type B heavy hepatitis jointly the curative effect and the security.Methods 72 example chronic Type B heavy hepatitis patient divides into 2 groups stochastically.The control group 32 examples give the conventional treatment;The treatment group 40 examples, in the conventional complex therapy's foundation, add with press the liver cell growth hormone to join to 5% glucose inoculation fluid 250 ml static drop, daily one time.Adefovir dipivoxil 10 mg, daily oral administration.Observes 2 groups to treat the liver function around separately and the zymoplasm original activity (PTA) , the blood serum HBV DNA level change and the curative effect situation.Results Treatment group total effectiveness is 85%, the control group is 50.0% (P <0.01) .Treats the latter 4 weeks, compares with the control group, the treatment group survival patient's total bilirubin reduces, the zymoplasm original activity (PTA) to elevate, the blood serum HBV DNA level reduces has statistics significance (P < 0.01) .Discovery obvious poisonous side effect.Conclusion The adefovir dipivoxil presses the liver cell growth hormone treatment chronic Type B heavy hepatitis to have the good curative effect and the security jointly.