Abstract: Objective To study the effect of percutaneous transsplenic variceal embolization (PTVE) on the liver function in patients suffering from upper gastrointestinal bleeding due to portal hypertension.Methods A total of 66 patients were included in the study and treated with PTVE (n = 36) and conservative medical treatment (n = 30) .The liver function in-dexes, Child-Pugh scores and bleeding recurrence rate were recorded for 6 months.Results The level of ALB, TBIL, PTA, NH3 and the Child-Pugh score showed a significant difference in PTVE group than the conservative medicine group (P values were <0.05, <0.01, <0.01, <0.001and <0.01, respectively) .Bleeding recurrence rate dramatically de-creased in PTVE group than the conservative medicine group (8.33% vs 26.7%, P < 0.05) .Conclusion PTVE not only reduce the recurrence rate of upper gastrointestinal bleeding due to high-pressure portal vein, but also improve the liver function.