Abstract: Objective To investigate the correlation between Child-Pugh Classification and, the blood levels of β2-mi-croglobulin and Arterial Oxygen in Patients with Liver Cirrhosis.Methods Fifty eight liver cirrhotic patients and 30 healthy controls were included in our study.Blood β2-microglobulin and partial pressure of oxygen in arterial blood were detected by radioimmunoassay and automatic blood gas analyzer, respectively.Results The Blood β2-microglobulin level in cirrhotic patients of Child B was significantly higher than that of child A and patients of Child C level was higher than that of child B.Arterial partial pressure of oxygen and the rate of hypoxemia were gradually decreased and increased in the pa-tients from child A, respectively.Conclusion The blood level of β2-microglobulin is associated with the severity of liver damage.The arterial partial pressure of oxygen gradually decreased with the aggravation of liver damage.The combined blood β2-microglobulin and arterial partial pressure of oxygen could be considered for the evaluation and prognosis of liver damage.