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Clinical observation of the therapeutic efficacy of elastase on hyperlipidemia with nonalcoholic fatty liver disease
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摘要: 观察弹性酶 (Elastase)治疗高脂血症伴非酒精性脂肪性肝病的临床疗效。高脂血症伴非酒精性脂肪性肝病治疗组 30例 ,口服弹性酶肠溶片 (30 0IU/片 ) ,2片 /次 ,3次 /日 ,6 0天为一疗程 ,安慰剂组 2 0例。通过测定肝功、血脂、肾功及B超随访。治疗组肝功能、血脂明显改善 ,优于对照组 (P <0 0 5 ) ,治疗组总有效率为 90 % ,明显优于对照组 10 % (P <0 0 5 )。弹性酶具有改善肝功能、降低血脂 ,防治高脂血症伴非酒精性脂肪性肝病的作用Abstract: To observe the therapeutic efficacy of elastase on hyperlipidemia with nonalcoholic fatty liver disease.The hyperlipidemic patients with nonalcoholic fatty liver disease were divided into two groups (treated group and control group) .The treated group (30 patients) were treated with elastase, while the control group (20 patients) were treated with placebo for sixty days, the manifestation, liver function, Serum, kidney function and type B ultrasonography of before and after treatment was observed.It was found that the degree of the improvement of the manifestation, liver function, lipids of the treated group was higher than of the control group significantly (P<0.05) , and the therapeutic efficacy of the treated group was better than that of the control group significantly (P<0.05) .So it conclude that elastase show therapeutic efficacy on hyperlipidemia with nonalcoholic fatty liver disease.
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Key words:
- elastase /
- hyperlipidemia /
- nonalcoholic fatty liver diseasc /
- therapeutic efficacy
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[1]中华医学会肝脏病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊断标准[J].中华肝脏病杂志, 2003, 11 (2) ∶71. [2] MarchesiniG , BriziM , BianchiG , etal.Nonalcoholicfattyliverdis ease:afeatureofthemetabolicsyndrome[J].Diabetes, 2001, 50∶1844-1845. [3] DayCP , JamesOFW .Steatohepatitis:ataleoftwohits?[J].JGas troenterology, 1998, 114∶842. [4] SanvalAJ .AGAtechnicalreviewonnonalcoholicfattyliverdisease[J].Gastroenterology, 2002, 123 (5) ∶1705～25. -
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