乙型肝炎患者血清HBVDNA负荷与其肝功能及肝组织损害的关系研究

柳龙根; 翟德芳; 刘健红; 钱梅云; 方国平

乙型肝炎患者血清HBVDNA负荷与其肝功能及肝组织损害的关系研究

基金项目:

常州市科学技术局资助 (常科发 [2 0 0 2 ] 69号 (1 0 ) )；

详细信息

中图分类号: R512.62
计量
- 文章访问数: 2233
- HTML全文浏览量: 15
- PDF下载量: 886
- 被引次数: 0
出版历程
- 出版日期: 2005-01-20

Researeh on the correlation between the contents of serum HBV DNA and liver function and liver tissue injury in hepatitis B patients.

Research funding:

摘要

摘要: 探讨乙肝患者血清HBVDNA含量与其肝功能及肝组织损害的关系。检测 380例未经治疗的乙肝患者血清HBVDNA、肝功能 ,其中 71例进行了肝活检。乙肝患者血清HBVDNA含量与其病情的严重程度不一致 ;临床各型乙肝中HBVDNA阳性组与阴性组间ALT、TBil均无显著差异 (P >0 0 5 ) ;肝组织炎症分级Gi～G4和纤维化分期S1～S4各组间HBVDNA值均无明显差异 (P >0 0 5 )。乙肝患者血清HBVDNA含量不能反映其病情的临床严重程度 ,与肝组织炎症和纤维化程度无关
- 乙型肝炎 /
- HBVDNA /
- 肝功能 /
- 肝组织
Abstract: To evaluate the serum HBV DNA level in hepatitis B and its relation with liver function and liver tissue injury.380 untreated patients with hepatitis B were selected and their serum HBVDNA level and liver function were detected, and among them 71 cases received liver biopsy.Serum HBVDNA level disaccord with state of their illness;serum ALT and TBil in those HBVDNA (+) and HBVDNA (-) have no difference (P>0.05) ;HAI scores have no relation with serum HBVDNA level (P>0.05) .Serum HBVDNA level cannot reflect the state of hepatitis illness, and no correlation with inflammation and fibrosis in liver.
- Hepatitis B /
- HBVDNA /
- Liver function Liver tissue /

HTML全文

参考文献(7)

[1]张玉琦, 周秀梅, 丁明权, 等.乙型肝炎患者血清HBVDNA水平与临床特征的关系[J].医学临床研究, 2003, 20 (9) ∶676-78.

[2]刘伟, 赵伟, 罗婵.慢性乙型肝炎得血清HBVDNA负荷与其肝组织炎症活动度相关性研究[J].临床肝胆病杂志, 2002, 18 (1) :26-27.

[3]陈然峰, 陈国军, 黄晓文, 等.HBVDNA的表达与肝纤维化的相关性研究[J].临床肝胆病杂志, 2002, 18 (6) ∶354-355.

[4]中华医学会病毒性肝炎防治方案[J].中华肝脏病杂志, 2000, 8 (6) :324-329.

[5]随云华, 杨志国, 许家璋, 等.HBVDNA定量与乙型肝炎临床及病理的关系[J].现代诊断与治疗, 2002, 13 (5) ∶266-268.

[6]成军, 杨守成, 现代肝炎病毒分子生物学[M ].北京∶人民军医出版社, 1997∶30.

[7] ZavagliaC , MondaziiL , MaggiG , etal.Arealanineaminotrans-ferase, hepatitisBvirusDNAorIgMantibodytohepatitisBcoreanti genserumlevelspredictorsofhistologicalgradinginchronichepatitisB ?[J].Liver, 17∶83-87.

施引文献

资源附件(0)

访问统计